The protective effect of modified nanodiamonds (MND) under the action of cobalt and nickel ions on the skin of Guinea pigs was shown. At the action of chromium ions on the skin of animals, the protective effect of MND was not found. The differences are related to different adsorption properties of MND to the investigated colored metal ions. It is shown in vitro that MND can adsorb ions of cobalt and nickel and don't bind ions of chromium from aqueous medium. The perspectives using of MND as a new drug for the prevention allergic dermatitis caused by action of bivalent ions of metals are discussed.
Experiments in vivo demonstrated the protective effect of modified nanodiamonds on guinea pig skin after local exposure cobalt ions, but not chrome ions. The observed differences are determined by different adsorption of these ions by nanodiamonds: in vitro experiments showed that nanodiamonds adsorbed cobalt ions, but not chrome ions from water solutions. The perspectives of using modified nanodiamonds as a new adsorbent for prevention of allergic contact dermatitis induced by ions of bivalent metals are discussed.
Дирофиляриоз-инфекция, широко распространенная среди собак в Северной и Южной Америке, Австралии, Европе, Японии, Индии и Китае [1]. Случай дирофиляриоза у человека впервые в литературе был описан еще в 1566 г. португальским врачом А. Лузитано [2] (описание клинического случая удаления червя из глаза 3-летней девочки). Дирофиляриоз у людей длительно считали редким, характерным для регионов с жарким климатом. Однако в последние годы данное заболевание распространилось, и участились случаи его верификации по всей территории России, включая Сибирь, отдаленные северные регионы (Якутия, Хабаровск и др.). Специалисты связывают расширение ареала данной инвазии с глобальным потеплением, а также
It is now known that one of the main causes of pathology of pregnancy, childbirth and placenta, is infection. The purpose of the study. To reveal the peculiarities of pregnancy and delivery, as well as histological changes of placenta in syphilitic infection, depending on the time of detection of the disease. The materials and methods of research. Under the supervision of 114 women with confirmed syphilis infection. In accordance with the intended purpose of the study three groups of women with syphilitic infection. Group I included 42 women who are diagnosed with syphilis installed for the first time in this period of pregnancy or nursing home. II group consisted of 34 women who have had syphilis prior to the present pregnancy had been trained in specific therapies, but during this pregnancy had a positive DAC. In the third group consisted of 38 women who had syphilis and received a course of specific therapy prior to the present pregnancy, with a negative DAC during this pregnancy. The control group included 30 women without a history of syphilis. Results and discussion. We found a significant increase in the overall frequency of complications in childbirth in women with syphilitic infection, the most common manifestation of the pathology of childbirth should be considered the changing nature of amniotic fluid and the need for manual examination of the uterine cavity. Degenerative changes in the form of petrification was absent in the control group and identified in women I-III bands 21.4-28.9 percent. Inflammatory changes of the placenta was detected with significantly higher frequency in group I. We found a significant prevalence of pathological changes in the stroma of the villi in placentas in groups I-III compared with the control. Conclusion. Leading macro- and microscopic pathological disorders of the placenta, concomitant syphilitic infection and emerging at 16-18 weeks of gestation and may be involved in the development of complications of pregnancy and childbirth.
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