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Acne vulgaris has a significant effect on the quality of life. Our results highlight the importance of recognizing psychiatric comorbidity in acne patients.

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27 April 2015.

IntroductionThe exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead and cadmium levels in seminal plasma of men with idiopathic oligoasthenozoospermia in comparison to fertile healthy controls and to correlate these levels with conventional semen parameters, sperm hypo-osmotic swelling (HOS) percentage, sperm DNA fragmentation percentage, and semen reactive oxygen species (ROS) levels.Material and MethodsThirty infertile male patients with idiopathic oligo and/or asthenozoospermia and thirty healthy fertile men, which was the control group, were included in the study. Lead and cadmium levels in seminal plasma, semen parameters, sperm HOS, sperm DNA fragmentation percentage and semen ROS assay were measured in all subjects.ResultsThere was a significant increase in seminal lead and cadmium levels among infertile males in comparison to controls. There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS). Importantly, significant positive correlations were noted between seminal lead and cadmium levels on one hand and sperm DNA fragmentation percentage and semen ROS level in infertile men and controls on the other hand.ConclusionsThus, men with idiopathic male infertility had higher levels of lead and cadmium in their semen which correlated with impairment of sperm motility and vitality percentages and more importantly with higher sperm DNA fragmentation% and semen ROS level.

Serum psoriasin and koebnerisin correlate with IMT, underlining their value as a potential link between psoriasis and atherosclerosis. In particular, koebnerisin seems to be a useful marker of subclinical atherosclerosis in patients with psoriasis.

Cytotoxic drugs and immunosuppressive therapies are used to treat patients with nonmalignant, nontesticular systemic diseases. These therapies can permanently suppress spermatogenesis. Sperm cryopreservation before treatment theoretically could give these men the opportunity to achieve a pregnancy with a woman later in life when the couple decides to do so. However, it is not known whether pretreatment sperm quality in these men is good enough to be used for assisted reproductive techniques. The main objective of this study was to determine the usefulness of cryopreservation in this patient population by: 1) assessing their pretreatment semen quality (eg, count, motility, and motion kinetics) and comparing it with that of healthy donors before and after cryopreservation; 2) comparing patients' pretreatment semen characteristics with World Health Organization reference values for normal sperm ; and 3) examining the differences in semen parameters among patient groups. Semen specimens were obtained from 25 healthy donors and from 23 patients with a variety of disorders ( 12 had autoimmune C ytotoxic drugs such as alkylating agents are commonly used to treat -people with malignant diseases. One of the main adverse effects of these drugs is impaired fertility in men. After treatment, recovery of spermatogenesis is often unpredictable (Thachil et al , 198 I ;Baker, 1998) and, in many cases, these drugs render men permanently infertile (Garns, 1980;Marmor, 1994 ). Thi s can have particularly devastating consequences for young men who have not yet started their families (Muller at al , 2000).Many studies have evaluated sperm cryopreservation for patients with cancer (Padron et al, I 997 ;Naysmith et al , 1998;Hallak et al , 1999). Even though cryopreservation can decrease sperm quality (Agarwal et al , 1995), recent advances in ass isted reproductive techniques make it possible to achi eve fertili zation with a single sperm (Tournaye et al, 1991 ). Thu s, in men with impaired fertility due to cyto~oxic cancer treatments, pretreatment 71disorders, 4 had kidney disorders, 3 had diabetes, 2 had ulcerative colitis, and 2 had heart transplants) . All patients, except those with diabetes, required immunosuppressive or cytotoxic therapy. Although the pretreatment quality of the semen of these patients was not as good as that of donors, semen samples were within the normal reference range of the World Health Organization . No statistically significant differences in sperm parameters were found within the 4 patient groups except for those with diabetes (n = 3), who showed poorer sperm counts (P < .04). However, no conclusive evidence can be reached due to the small sample size. Our results indicate that pretreatment semen quality in these patients is adequate for reproductive techniques. We believe that cryopreservation should be offered to patients of reproductive age with disease or treatment regimens that may cause infertility.

Warts are common skin infections with both physical and psychological impacts. 1 It is caused by human papillomavirus (HPV). HPV is an icosahedral nonenveloped, double-stranded DNA virus which can cause a variety of skin presentations according to its type, site, and the immune status. Nongenital warts may be presented as common, plane, planter, filiform, or mucosal warts. The prevalence of skin warts is between 2.4% and 12.9%. 2 Researchers are still trying to find an ideal treatment modality for warts which should be curative, painless, without side effects, and with no recurrence. Current treatment options include topical,