Alopecia areata is not associated with  Helicobacter pylori

Hafez, Hisham Z Abdel; Mahran, Ali; Hofny, Eman M; Attallah, Dalia A.; Sayed, Doaa S.; Rashed, Heba

doi:10.4103/0019-5154.48979

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…Attempts to investigate the role of H. pylori in this disease have been very few and led to inconclusive results [97,98] . Seroprevalence rates of H. pylori infection in patients with AA are increased or not compared to controls [97,99] . Eradication of H. pylori in AA has also been proposed [100] , but not studied extensively.…”

Section: Alopecia Areatamentioning

confidence: 99%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

145

108

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Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of autoimmune gastritis. However, a considerable number of reports have attempted to link H. pylori infection with the development of extra-gastrointestinal autoimmune disorders, affecting organs not immediately relevant to the stomach. This review discusses the current evidence in support or against the role of H. pylori as a potential trigger of autoimmune rheumatic and skin diseases, as well as organ specific autoimmune diseases. We discuss epidemiological, serological, immunological and experimental evidence associating this pathogen with autoimmune diseases. Although over one hundred autoimmune diseases have been investigated in relation to H. pylori, we discuss a select number of papers with a larger literature base, and include Sjögrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, vasculitides, autoimmune skin conditions, idiopathic thrombocytopenic purpura, autoimmune thyroid disease, multiple sclerosis, neuromyelitis optica and autoimmune liver diseases. Specific mention is given to those studies reporting an association of anti-H. pylori antibodies with the presence of autoimmune disease-specific clinical parameters, as well as those failing to find such associations. We also provide helpful hints for future research.

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Section: Alopecia Areatamentioning

confidence: 99%

Helicobacter pyloriand autoimmune disease: Cause or bystander

Smyk¹,

Κουτσουμπασ²,

Mytilinaiou³

et al. 2014

WJG

145

108

View full text Add to dashboard Cite

show abstract

“…It is caused by CD4+ and CD8+ T cells targeting the hair follicles as an autoimmune-mediated skin. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Evaluation of association of vitamin D in alopecia areata: A case–control study of 100 patients in a tertiary rural hospital of Southern India

Siddappa

Kumar

Vivekananda

2019

Indian Dermatol Online J

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“…As far as other dermatologic diseases such as alopecia areata (AA), Behçet’s disease etc., are concerned, no correlation with H. pylori infection could be established [33–35].…”

Section: Ophtalmology Skin and Oral Mucosa Diseasesmentioning

confidence: 99%

Extragastric Manifestations of Helicobacter pylori Infection

et al. 2010

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Since the discovery of Helicobacter pylori infection, several authors have investigated the immunological properties expressed by the bacterium in relation to the host. Those studies were expressly aimed at demonstrating how H. pylori may cause gastric mucosal damage and, at the same time, elude the immunological response evoked by the host. Data collected from those studies clearly showed that the immunological response caused by this bacterium is not only locally oriented but also systemically and that this immunological response may virtually cause local damage as well as influence the clinical course of other diseases, outside the stomach, thus opening the field of extragastric manifestations of H. pylori infection that we review in this manuscript. Cardiovascular DiseasesSome reviews have suggested a possible role of H. pylori infection in ischemic heart disease (IHD) [1][2][3][4][5][6][7]. Furthermore, there are also original studies conducted in this field, showing very interesting results. A study by Ayada et al. clearly showed that H. pylori promotes atherogenesis in heterozygous apoe (+ ⁄ )) ldlr (+ ⁄ )) mice. In particular, H. pylori infected and noninfected mice were fed a high fat diet from the age of 6 weeks; development of atherosclerotic lesions was observed in infected animals and correlated with an elevation of Th1-immune response against H. pylori heat shock protein 60. To confirm the plausibility of this hypothesis, H. pylori eradication significantly reduced the progression of atherosclerosis in infected mice [8]. A study by our group also showed a highly positive correlation between H. pylori and IHD. In particular, we performed a clinico-pathological study on patients with stable angina, unstable angina and normal controls and a meta-analysis in the attempt to shed new light on this complex issue. Anti-urease B and anti-CagA antibodies were assessed in all patients; moreover, coronary atherosclerotic plaque specimens were obtained by patients with stable and unstable angina and used for immunohistochemistry using anti-CagA antibodies. Interestingly, the anti-CagA but not anti-urease B antibody titer was significantly higher in patients with unstable angina compared to stable. Moreover, anti-CagA antibodies recognized antigens localized inside coronary atherosclerotic plaques. In the meta-analysis, seropositivity to CagA was significantly associated with the occurrence of acute coronary events with an adjusted odds ratio (OR) of 1.34 (95% confidence interval (CI), 1.15-1.58, p = .003). Thus, taken together, these findings suggest that in a subset of patients with unstable angina, an intense immune response against CagA-positive strains might act as a trigger for the precipitation of coronary instability via a molecular mimicry mechanism [9]. Another study by Jia et al.[10] reported a strong correlation between H. pylori infection and decreased levels of HDL cholesterol, which has been Keywords Idiopathic thrombopenic purpura, iron deficiency anemia, obesity, CagA, molecular mimicry.Reprint ...

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Alopecia areata is not associated with Helicobacter pylori

Cited by 9 publications

References 9 publications

Helicobacter pyloriand autoimmune disease: Cause or bystander

Helicobacter pyloriand autoimmune disease: Cause or bystander

Evaluation of association of vitamin D in alopecia areata: A case–control study of 100 patients in a tertiary rural hospital of Southern India

Extragastric Manifestations of Helicobacter pylori Infection

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