Evaluation of association of vitamin D in alopecia areata: A case–control study of 100 patients in a tertiary rural hospital of Southern India

Siddappa, Harsha; Kumar, Y Hari Kishan; Vivekananda, N

doi:10.4103/idoj.idoj_84_18

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…However, we acknowledge the need for more large‐scale studies to confirm these findings, particularly regarding FPHL and AGA. In two separate studies, Siddappa, an Indian author, investigated 25(OH)D levels in 30 AA patients under 18 years of age and 100 adult AA patients, both of which exhibited lower 25(OH)D levels and higher incidence of vitamin D deficiency 17,18 . A study conducted in India revealed that patients with AA had a vitamin D deficiency especially in the winter and autumn.…”

Section: Discussionmentioning

confidence: 99%

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Chen,

Dong,

Wang

et al. 2023

J of Cosmetic Dermatology

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IntroductionNon‐scarring alopecia mainly includes androgenetic alopecia (AGA), female pattern hair loss (FPHL), alopecia areata (AA), telogen effluvium (TE), anagen effluvium (AE) and so on. Many studies had investigated the serum 25‐hydroxyvitamin D level and vitamin D deficiency of patients with these diseases, but opinions varied, and no conclusion was reached.MethodsRelevant articles were retrieved through PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) and other databases. Serum 25‐hydroxyvitamin D [25(OH) D] levels and vitamin D deficiency were used as our primary outcome. The odds ratio (OR) and the standardized mean difference (SMD) with 95% confidence interval were both examined for vitamin D deficiency and levels.ResultsOur meta‐analysis had included a total of 3374 non‐scarring alopecia patients and 7296 healthy controls from 23 studies through the inclusion criteria and exclusion criteria. We found non‐scarring alopecia had decreased serum 25(OH)D level (WMD −7.29; 95% CI −9.21, −5.38) and increased vitamin D deficiency incidence (OR 3.11 95% CI 2.29, 4.22), compared with healthy controls. This meta‐analysis chose to conduct random‐effect model and subgroup analysis, because of the high heterogeneity (serum 25(OH)D level: I2 = 95%, vitamin D deficiency: I2 = 0%).ConclusionPatients with non‐scarring alopecia (including AA, FPHL, AGA and TE) have insufficient serum level of 25(OH)D and increased incidence of vitamin D deficiency. Vitamin D supplementation and monitoring for vitamin D deficiency may be helpful in treating non‐scarring alopecia.

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Section: Discussionmentioning

confidence: 99%

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Chen,

Dong,

Wang

et al. 2023

J of Cosmetic Dermatology

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Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis

Liu

Liang

et al. 2020

Dermatol Ther (Heidelb)

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Introduction: To investigate the associations of alopecia areata (AA) with serum vitamin D and calcium levels. Methods: A systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-hydroxyvitamin D [25(OH)D] levels and vitamin D deficiency, and the secondary endpoint was serum calcium level. Odds ratio (OR) and standardized mean difference (SMD) with 95% CI across studies were analyzed. Results: Data on 1585 patients with AA and 1114 controls from 16 case-control studies and three cross-sectional studies were included in this meta-analysis. A pooled meta-analysis was conducted using the random-effects model because of inter-study heterogeneity (vitamin D level, I 2 = 87.90%; vitamin D deficiency, I 2 = 81.10%; serum calcium level, I 2 = 83.80%). A combined analysis revealed that patients with AA had significantly lower mean serum 25(OH)D level compared with control (WMD-9.08, 95% CI-11.65,-6.50, p \ 0.001), and were more likely to have vitamin D deficiency (OR 4.14, 95% CI 2.34, 7.35, p \ 0.001). However, the pooled analysis revealed that patients with AA did not have significantly lower serum calcium levels compared with control (WMD-0.17, 95% CI-0.40, 0.06, p = 0.143). Subgroup analysis suggested that matched control, mean age, and country might contribute to the heterogeneity of serum vitamin D level, while study design, matched control, and country might contribute to the heterogeneity of vitamin D deficiency. Conclusion: Deficiency of serum 25(OH)D level, rather than calcium level, was present in patients with AA. Screening for vitamin D deficiency and vitamin D supplementation may be beneficial in the treatment of patients with AA.

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Biomarkers in alopecia Areata: A systematic review and meta-analysis.

Zaaroura¹,

Gilding²,

Sibbald³

2023

Autoimmunity Reviews

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Evaluation of association of vitamin D in alopecia areata: A case–control study of 100 patients in a tertiary rural hospital of Southern India

Cited by 7 publications

References 18 publications

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Serum 25 hydroxyvitamin D in non‐scarring alopecia: A systematic review and meta‐analysis

Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis

Biomarkers in alopecia Areata: A systematic review and meta-analysis.

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