Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus)

Albadrany, Yasser M.; Naser, Ahmed

doi:10.14202/vetworld.2020.642-648

Cited by 10 publications

(11 citation statements)

References 35 publications

(33 reference statements)

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“…Experiments were conducted when the ages of the chicks were between 7-9 days. This is a suitable experimental animal (chick) model used previously in pharmacological and toxicological studies (8)(9)(10)(11). The Alpha lipoic acid (Lipoic-Forte by AMS®), formalin, and their suppliers were as follows.…”

Section: Methodsmentioning

confidence: 99%

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Rehab

Naser

2022

IJVS

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Alpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain. The up and down method was used to calculate the median effect of the analgesic dose. The ED50 of ALA was 45.18 and 74.56 mg/kg intraperitoneally by electrical stimulation and hot water test, respectively. We demonstrated that the peak of analgesic effect was after one hour by using different doses and different times. ALA at 0, 75, 150, 300 mg/kg intraperitoneally produces a dose-dependent analgesic effect by formalin test. In conclusion: ALA induced analgesic activity, probably by closing voltage-gated calcium and or voltage-gated sodium channels. These outcomes show that therapeutic doses of ALA can affect pain and may mask or reduce nociception induced by acute pain models.

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Section: Methodsmentioning

confidence: 99%

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Rehab

Naser

2022

IJVS

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“…Albadrany et al. [ 51 ] demonstrated that CoQ10 could not alleviate diclofenac-induced renal injury, but worsened the impaired renal function in a broiler chicken model. Obviously, this study exhibits a quite opposite trend of the roles of CoQ10 in AKI.…”

Section: Protective Properties Of Coq10 In Aki Reported In Experiment...mentioning

confidence: 99%

“…Obviously, this study exhibits a quite opposite trend of the roles of CoQ10 in AKI. It was suggested that COQ10 co-administered with diclofenac might cause a synergistic detrimental effect on renal tissue [ 51 ]. Moreover, it was speculated that COQ10 might inhibit prostaglandin synthesis in the kidney, similar to the biological effects of NSAIDs [ 51 ].…”

Section: Protective Properties Of Coq10 In Aki Reported In Experiment...mentioning

confidence: 99%

“…2019 [ 50 ] Rats Renal ischemia–reperfusion injury 10 mg/kg, intraperitoneally NA CoQ10 decreased tissue oxidative stress levels and scores of histopathology and apoptosis Albadrany et al. 2019 [ 51 ] Broiler chickens Diclofenac-induced renal injury (1 and 2 mg/kg, i.p.) 30 mg/kg, orally NA CoQ10 could not alleviate diclofenac-induced renal injury, but worsened impaired renal function Kennedy et al.…”

Section: Introductionmentioning

confidence: 99%

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Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Zhao

Wu²,

Liao

et al. 2022

Cell Mol Biol Lett

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Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently to exert an outstanding protective effect on multiple organ injury, including acute kidney injury (AKI). In this study, we aim to summarize all the current evidence of the protective action of CoQ10 against AKI as there are presently no relevant reviews in the literature. After a systematic search, 20 eligible studies, either clinical trials or experimental studies, were included and further reviewed. CoQ10 treatment exhibited a potent renal protective effect on various types of AKI, such as AKI induced by drugs (e.g., ochratoxin A, cisplatin, gentamicin, L-NAME, and nonsteroidal anti-inflammatory drug), extracorporeal shock wave lithotripsy (ESWL), sepsis, contrast media, and ischemia–reperfusion injury. The renal protective role of CoQ10 against AKI might be mediated by the antiperoxidative, anti-apoptotic, and anti-inflammatory potential of CoQ10. The molecular mechanisms for the protective effects of CoQ10 might be attributed to the regulation of multiple essential genes (e.g., caspase-3, p53, and PON1) and signaling cascades (e.g., Nrf2/HO-1 pathway). This review highlights that CoQ10 may be a potential strategy in the treatment of AKI.

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“…Diclofenac sodium is a Non-Steroidal Anti-Inflammatory Drug (NSAID), with an average relative inhibition cyclooxygenase 1 and 2 (1). Diclofenac has serious pathological effects such as stomach ulceration, GIT bleeding, liver toxicity, kidney papillary necrosis as well as kidney failure on uses for long periods (2). Recently, use of natural compounds, including those extracted from vegetables, fruits, and herbs, as powerful preventive or therapeutic agents has become a promising approach for inflammation-associated disease chemoprevention (3).…”

Section: Introductionmentioning

confidence: 99%

Study the analgesic effect of diclofenac and silymarin coadministration in chicks

Albadrany¹,

Naser²,

Hasan³

2021

IJVS

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The study aimed to investigate the analgesic as well as anti-inflammatory effects of diclofenac and silymarin in chicks. The up and down procedure was used to assess the effective median analgesic dosages (ED50s) of diclofenac and silymarin administered intraperitoneally either alone or at the same time in chicks. Also, Analgesic and antiinflammatory effects were measured by using the formalin test. Isobolographically, ED50s of drugs were assessed for the manner of interaction between both. Formalin testing also supervised analgesic and anti-inflammatory coadministration impact of diclofenac and silymarin at doses 5 and 40 mg/kg and 2.5 and 20 mg/kg respectively. Analgesic ED50s for diclofenac and silymarin in chicks were 9.3 and 76.6 mg/kg separately. Concomitant administration of drugs at a fixed ratio 0.5:0.5 and 0.25:0.25 of their individual ED50 values reduced their ED50s to 2.3:18.6 mg/kg and 2.2:16.5 mg/kg separately. ED50s isobolographic analysis showed synergistic analgesic effects of both drugs. Additionally, coadministration of both drugs had effective analgesic and anti-inflammatory effect, as seen by formalin test, led to a significant rise in latency to lift right foot beside a significant decline in foot lifting frequency when compared with control value, the antiinflammatory reaction was demonstrated by a significant decrease in foot thickness compared to control value. In conclusion, the data indicate that diclofenac and silymarin coadministration controls acute pain synergistically, and suppress inflammatory reaction.

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Coenzyme Q10 coadministration with diclofenac augmented impaired renal function in broiler chickens (Gallus gallus domesticus)

Cited by 10 publications

References 35 publications

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Study the analgesic effect of diclofenac and silymarin coadministration in chicks

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