Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Zhao, Shankun; Wu, Weizhou; Liao, Jian; Zhang, Xinsheng; Shen, Maolei; Li, Xin; Qi, Lin; Cao, Chaoliang

doi:10.1186/s11658-022-00361-5

Cited by 10 publications

(3 citation statements)

References 99 publications

(124 reference statements)

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“…AKI is a commoncondition marked by a sudden decrease in renal function. Various pathological factors, including I/R, sepsis, trauma and exposure to nephrotoxic substances can trigger AKI [ 216 , 217 ]. Kidney I/R is one of the most common causes of AKI.…”

Section: Acute Kidney Injury (Aki)mentioning

confidence: 99%

Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies

Vahidinia,

Azami Tameh,

Barati

et al. 2024

Cell Mol Biol Lett

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Exosomes are nano-sized membrane extracellular vesicles which can be released from various types of cells. Exosomes originating from inflammatory or injured cells can have detrimental effects on recipient cells, while exosomes derived from stem cells not only facilitate the repair and regeneration of damaged tissues but also inhibit inflammation and provide protective effects against various diseases, suggesting they may serve as an alternative strategy of stem cells transplantation. Exosomes have a fundamental role in communication between cells, through the transfer of proteins, bioactive lipids and nucleic acids (like miRNAs and mRNAs) between cells. This transfer significantly impacts both the physiological and pathological functions of recipient cells. Nuclear factor erythroid 2–related factor 2 (Nrf2), a transcription factor, is able to mitigate damage caused by oxidative stress and inflammation through various signaling pathways. The positive effects resulting from the activation of the Nrf2 signaling pathway in different disorders have been documented in various types of literature. Studies have confirmed that exosomes derived from stem cells could act as Nrf2 effective agonists. However, limited studies have explored the Nrf2 role in the therapeutic effects of stem cell-derived exosomes. This review provides a comprehensive overview of the existing knowledge concerning the role of Nrf2 signaling pathways in the impact exerted by stem cell exosomes in some common diseases. Graphical Abstract

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Section: Acute Kidney Injury (Aki)mentioning

confidence: 99%

Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies

Vahidinia,

Azami Tameh,

Barati

et al. 2024

Cell Mol Biol Lett

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“…This mechanism can support lung cancer cell growth and facilitate their invasion [ 110 ]. Upregulation of miR-374b-5p in exosomes, derived from hypoxic tubular epithelial cells (TECs), reduces SOCS1 expression and promotes M1 macrophage activation during renal ischemia–reperfusion injury (RIRI) conditions [ 124 , 125 ]. Exosomes derived from polymorph nuclear neutrophils (PMNs) have an important role in sepsis-related ALI.…”

Section: Exosomes Involve In Macrophage Polarizationmentioning

confidence: 99%

The role of macrophage subtypes and exosomes in immunomodulation

et al. 2022

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Macrophages are influential members of the innate immune system that can be reversibly polarized by different microenvironment signals. Cell polarization leads to a wide range of features, involving the migration, development, and organization of the cells. There is mounting evidence that macrophage polarization plays a key role in the initiation and development of a wide range of diseases. This study aims to give an overview of macrophage polarization, their different subtypes, and the importance of alternatively activated M2 macrophage and classically activated M1 macrophage in immune responses and pathological conditions. This review provides insight on the role of exosomes in M1/M2-like macrophage polarization and their potential as a promising therapeutic candidate.

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“…To fight kidney diseases, numerous therapeutic approaches have been explored [ 10 , 11 , 12 , 13 ]. These include exogenous and endogenous compounds, dietary manipulations, modulation of metabolic pathways, stem cell approaches, and cell signaling processes [ 10 , 11 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. In this review article, we will focus on the role of lipoic acid in preventing and ameliorating kidney injuries.…”

Section: Introductionmentioning

confidence: 99%

Renal-Protective Roles of Lipoic Acid in Kidney Disease

Kamt

Liu

2023

Nutrients

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The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious elements. It also participates in the regulation of blood pressure, maintenance of electrolyte balance and blood pH homeostasis, as well as erythropoiesis and vitamin D maturation. Due to such a heavy workload, the kidney is an energy-demanding organ and is constantly exposed to endogenous and exogenous insults, leading to the development of either acute kidney injury (AKI) or chronic kidney disease (CKD). Nevertheless, there are no therapeutic managements to treat AKI or CKD effectively. Therefore, novel therapeutic approaches for fighting kidney injury are urgently needed. This review article discusses the role of α-lipoic acid (ALA) in preventing and treating kidney diseases. We focus on various animal models of kidney injury by which the underlying renoprotective mechanisms of ALA have been unraveled. The animal models covered include diabetic nephropathy, sepsis-induced kidney injury, renal ischemic injury, unilateral ureteral obstruction, and kidney injuries induced by folic acid and metals such as cisplatin, cadmium, and iron. We highlight the common mechanisms of ALA’s renal protective actions that include decreasing oxidative damage, increasing antioxidant capacities, counteracting inflammation, mitigating renal fibrosis, and attenuating nephron cell death. It is by these mechanisms that ALA achieves its biological function of alleviating kidney injury and improving kidney function. Nevertheless, we also point out that more comprehensive, preclinical, and clinical studies will be needed to make ALA a better therapeutic agent for targeting kidney disorders.

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Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Cited by 10 publications

References 99 publications

Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies

Nrf2 activation: a key mechanism in stem cell exosomes-mediated therapies

The role of macrophage subtypes and exosomes in immunomodulation

Renal-Protective Roles of Lipoic Acid in Kidney Disease

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