Assessment of the analgesic effect of Alpha-lipoic acid by three acute pain models

Abstract

Alpha-lipoic acids are Known as a good analgesic in neuropathic pain, especially in diabetic patients. This research aimed to assess the analgesic activity of ALA by three acute pain models using broiler chicks. We used electrical stimulation, hot water test, and formalin test to elicit acute pain. The up and down method was used to calculate the median effect of the analgesic dose. The ED50 of ALA was 45.18 and 74.56 mg/kg intraperitoneally by electrical stimulation and hot water test, respectively. We demonstrated that the peak of analgesic effect was after one hour by using different doses and different times. ALA at 0, 75, 150, 300 mg/kg intraperitoneally produces a dose-dependent analgesic effect by formalin test. In conclusion: ALA induced analgesic activity, probably by closing voltage-gated calcium and or voltage-gated sodium channels. These outcomes show that therapeutic doses of ALA can affect pain and may mask or reduce nociception induced by acute pain models.

Flurbiprofen: Determination of safety profile, analgesic effect, and interaction with lipoic acid in murine

“…Alpha-lipoic acid is an antioxidant agent that has a clinical benefit in treating neuropathic disorders, especially in patients with diabetes (11). Lipoic acid has potent painkiller efficacy for mild pain (12), an antichronic inflammation effect (13), a hypothermic effect (13), and a depression effect on the CNS of poultry (14), and alpha-lipoic acid can treat hepatic and renal damage caused by diclofenac (15). This study aimed to evaluate the therapeutic index of flurbiprofen, as well as the analgesic effects of two different methods for assessing analgesia in peripheral and visceral pain and its interaction with alpha-lipoic acid in mice.…”