Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating

Boutros, Nash N.; Gooding, Diane C.; Sundaresan, Karthikeyan; Burroughs, Scott; Johanson, Chris E.

doi:10.1016/j.psychres.2006.02.005

Cited by 36 publications

(47 citation statements)

References 31 publications

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“…17 The limitations of this study are the limited number of subjects and high incidence of substance abuse. Substance abuse or withdrawal could have confounded our findings, 5,9 although the AAB and ASPD samples had similarly increased prevalence of substance or alcohol-related disorders. This aspect requires more research.…”

Section: Discussionmentioning

confidence: 80%

“…[5][6][7][8][9][10][11] Additionally, the association between P50 ratio and number of symptoms for conduct disorder, but not adult antisocial behavior, suggests a continuum of weaker P50 gating from AAB to ASPD depending on the severity of antisocial behavior in childhood.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Strong evidence exists that P50 gating is impaired in psychosis-related disorders, such as schizophrenia, 3 and anxiety/stress-related disorders, such as posttraumatic stress disorder. 4 Although not addressed directly, recent findings also suggest weaker gating in disorders associated with pathological impulsivity, including alcohol abuse, 5-7 substance abuse, 5,8,9 adult attention-deficit hyperactivity disorder (ADHD), 10 bipolar disorder without psychosis, 11 and violence in schizophrenia, 1 even though in most of these studies results may be affected by overlap with psychosis-or anxiety-related disorders. Interestingly, Thoma et al 7 showed that subjects with combined alcohol abuse disorder and schizophrenia had more severely impaired P50 gating than either disorder alone, suggesting partially independent mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Lijffijt¹,

Moeller²,

Boutros³

et al. 2009

Journal of Neuropsychiatry

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The authors investigated preattentive filtering assessed by P50 gating in nine participants with antisocial personality disorder (ASPD) and seven with adult-onset antisocial behavior (AAB). Relative to 15 comparison subjects, gating was impaired in ASPD, suggesting abnormal pre-attentive filtering in pathological impulsivity.Repetition-induced reduction in P50 amplitude (P50 gating) could reflect a preattentive mechanism that filters out irrelevant information, affecting cognitive and motor processes and task performance. 1,2 Strong evidence exists that P50 gating is impaired in psychosis-related disorders, such as schizophrenia, 3 and anxiety/stress-related disorders, such as posttraumatic stress disorder. 4 Although not addressed directly, recent findings also suggest weaker gating in disorders associated with pathological impulsivity, including alcohol abuse, 5-7 substance abuse, 5,8,9 adult attention-deficit hyperactivity disorder (ADHD), 10 bipolar disorder without psychosis, 11 and violence in schizophrenia, 1 even though in most of these studies results may be affected by overlap with psychosis-or anxiety-related disorders. Interestingly, Thoma et al. 7 showed that subjects with combined alcohol abuse disorder and schizophrenia had more severely impaired P50 gating than either disorder alone, suggesting partially independent mechanisms.Antisocial personality disorder (ASPD) is a disorder of pathological impulsivity without psychosis or anxiety. True ASPD, with childhood onset of antisocial behavior, differs in clinical characteristics from adolescent-or adult-onset antisocial behavior (AAB) by being associated with more pervasive sociodevelopmental, cognitive, and behavioral disturbances. 12 pilot study we investigated the relationship between P50 gating and pathological impulsivity directly in ASPD and AAB patients without past or current psychosis-or anxiety-related disorders. We expected impaired P50 gating in subjects with antisocial behavior relative to healthy comparison subjects. Methods ParticipantsAll subjects were recruited from the general population through advertisements. Participants completed the Structured Clinical Interview for DSM-IV axis I and axis II disorders (SCID-I and SCID-II). 13 Participants with antisocial behavior met criteria for ASPD or AAB. Healthy comparison subjects were required to have no current or past axis I or axis II disorders and to have no first-degree relatives with axis I or II disorders. Further criteria were age between 18 and 55 years old, hearing at least 60 dB, (corrected-to-) normal vision, no head trauma or epilepsy, and no current use of psychoactive medicine. Participants signed informed consent before participation. The study complied with the Declaration of Helsinki and was approved by the Committee for the Protection of Human Subjects institutional review board for the University of Texas Health Science Center at Houston.There were sixteen antisocial patients (mean age=34.50 years, SD=9.16) of whom three were female; the group included nin...

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Lijffijt¹,

Moeller²,

Boutros³

et al. 2009

Journal of Neuropsychiatry

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“…Estes trabalhos mostraram uma diminuição das amplitudes e aumento das latências dos potenciais evocados auditivos de média e longa latência entre usuários de drogas, mesmo em períodos de abstinência, o que também é observado em pacientes esquizofrênicos/com transtornos psiquiátricos e em pessoas que mostraram uma maior chance de desenvolverem problemas com drogas e álcool. Os achados alterados dos potenciais evocados auditivos de média e longa latência, nestes casos, sugerem uma inabilidade de filtrar estímulos sensoriais não relevantes, de atenção seletiva, de manutenção da memória de trabalho e de discriminação, bem como foram associados com a existência de maior impulsividade (21)(22)(23) . A análise das latências absolutas e interpicos dos potenciais evocados auditivos de tronco encefálico (PEATE) feita no presente estudo não revelou diferenças entre os grupos de usuários de drogas e o grupo controle.…”

Section: Discussionunclassified

Potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas

Nigri¹,

Samelli

Schochat

2009

Rev. soc. bras. fonoaudiol.

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RESUMOObjetivo: Analisar os potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas, bem como levantar as possíveis queixas auditivas e de equilíbrio nesta população. Métodos: Foram avaliados 40 usuários de drogas (20 com uso há mais de cinco anos e 20 há menos de cinco anos) e 20 não usuários, do sexo masculino, com idades entre 19 e 46 anos, com limiares auditivos dentro da normalidade. Resultados: Não houve diferenças significativas dos potenciais evocados auditivos de tronco encefálico dos usuários de drogas quando comparados ao grupo controle. Conclusão: Os potenciais evocados auditivos de tronco encefálico dos usuários de drogas não diferiram significantemente do grupo controle. As queixas apresentadas pelos usuários de drogas foram hiperacusia, alucinação auditiva, zumbido e alteração de equilíbrio.Descritores: Audição; Potenciais evocados auditivos do tronco encefálico; Efeitos de drogas; Cocaína/efeitos adversos; Cocaína crack/efeitos adversos; Drogas ilícitas/efeitos adversos INTRODUÇÃO O consumo de substâncias psicoativas tem gerado, em todas as partes do mundo, problemas sociais e de saúde pública de grande importância, devido a sua crescente prevalência (1)(2)(3) . A cocaína é um alcalóide extraído da folha da Erythroxylon coca; pode ser encontrada em duas formas: sal de hidrocloreto e "base livre". A primeira forma pode ser utilizada por via oral, injetada ou inalada; já a "base livre" é a mistura da cocaína com a amônia e o bicarbonato de sódio, que é usada para fumar (crack), sendo considerada a forma mais potente da droga (4) . A cocaína, quando inalada, é absorvida rapidamente pe los vasos pulmonares e atinge a circulação cerebral em aproximadamente seis a oito segundos, produzindo intensa euforia. As maiores concentrações da droga são encontradas no cérebro, no baço, nos rins e no pulmão (4) . Pesquisas têm mostrado que a cocaína promove alterações degenerativas nos neurônios e células gliais, assim como modificações nas funções dos receptores, na produção e na liberação de alguns neurotransmissores. Contudo, os processos neuroquímicos e vasculares envolvidos nesta aparente neurotoxicidade não foram ainda esclarecidos totalmente (3) . O uso de drogas por mulheres grávidas é um assunto bem conhecido e estudado. Sabe-se que o uso de drogas materno tem efeito no desenvolvimento do cérebro fetal, podendo ocorrer de duas formas principais: nas primeiras 20 semanas de gestação, atuando sobre a citogênese e a migração celular; na segunda metade da gestação, atuando sobre o crescimento do cérebro e sua diferenciação. A cocaína tem livre acesso na barreira placentária e pode causar hipóxia fetal em virtude da vasoconstrição placentária. Além disso, estudos animais mostraram alterações na organização e migração de neurônios e células da glia (5) . A cocaína utilizada durante a gestação pode alterar também o sistema auditivo. Crianças expostas à cocaína durante o período pré-natal mostraram latências absolutas e interpicos prolongados referentes aos Potenciais Evocados ...

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“…As we discussed in this study, less positive stimulus‐locked P2 is thought to index early sensory gating and the ability of individuals to filter extraneous information when allocating attention (Boutros et al. 2006; Lijffijt et al. 2009), and Pe is thought to index conscious evaluation of errors, response strategy adjustments, and/or affective assessment of error (Nieuwenhuis et al.…”

Section: Introductionmentioning

confidence: 99%

Brain potentials predict substance abuse treatment completion in a prison sample

et al. 2016

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IntroductionNational estimates suggest that up to 80% of prison inmates meet diagnostic criteria for a substance use disorder. Because more substance abuse treatment while incarcerated is associated with better post‐release outcomes, including a reduced risk of accidental overdose death, the stakes are high in developing novel predictors of substance abuse treatment completion in inmate populations.MethodsUsing electroencephalography (EEG), this study investigated stimulus‐locked ERP components elicited by distractor stimuli in three tasks (VO‐Distinct, VO‐Repeated, Go/NoGo) as a predictor of treatment discontinuation in a sample of male and female prison inmates. We predicted that those who discontinued treatment early would exhibit a less positive P3a amplitude elicited by distractor stimuli.ResultsOur predictions regarding ERP components were partially supported. Those who discontinued treatment early exhibited a less positive P3a amplitude and a less positive PC4 in the VO‐D task. In the VO‐R task, however, those who discontinued treatment early exhibited a more negative N200 amplitude rather than the hypothesized less positive P3a amplitude. The discontinuation group also displayed less positive PC4 amplitude. Surprisingly, there were no time‐domain or principle component differences among the groups in the Go/NoGo task. Support Vector Machine (SVM) models of the three tasks accurately classified individuals who discontinued treatment with the best model accurately classifying 75% of inmates. PCA techniques were more sensitive in differentiating groups than the classic time‐domain windowed approach.ConclusionsOur pattern of findings are consistent with the context‐updating theory of P300 and may help identify subtypes of ultrahigh‐risk substance abusers who need specialized treatment programs.

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Cocaine-dependence and cocaine-induced paranoia and mid-latency auditory evoked responses and sensory gating

Cited by 36 publications

References 31 publications

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

A Pilot Study Revealing Impaired P50 Gating in Antisocial Personality Disorder

Potenciais evocados auditivos de tronco encefálico em usuários de crack e múltiplas drogas

Brain potentials predict substance abuse treatment completion in a prison sample

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