Brain potentials predict substance abuse treatment completion in a prison sample

Fink, Brandi C.; Steele, Vaughn R.; Maurer, Michael; Fede, Samantha J.; Calhoun, Vince D.; Kiehl, Kent A.

doi:10.1002/brb3.501

Cited by 28 publications

(26 citation statements)

References 43 publications

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“…Most measures of large-scale networks implement MRI based measures, but EEG measures of large-scale networks via phase synchrony holds tremendous potential due to its exquisite temporal resolution (e.g., Aviyente et al, 2017;Watts et al, 2018). Event-related potentials (ERPs) assessing cognitive functions have also successfully predicted SUD treatment outcomes (Fink et al, 2016;Marhe et al, 2013;Nakamura-Palacios et al, 2016;Steele et al, 2014). Biomarker development incorporating multimodal measures, rather than a single modality, and taking advantage of both the high spatial resolution of fMRI and high temporal resolution of EEG is likely to provide a more complete picture of both the cognitive functions and the underlying mechanisms dysregulated in SUD.…”

Section: Biomarkers For Treatment Selection and Monitoringmentioning

confidence: 99%

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Ekhtiari

Tavakoli

Addolorato

et al. 2019

Neuroscience & Biobehavioral Reviews

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There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data-emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

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Section: Biomarkers For Treatment Selection and Monitoringmentioning

confidence: 99%

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Ekhtiari

Tavakoli

Addolorato

et al. 2019

Neuroscience & Biobehavioral Reviews

Self Cite

223

189

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“…Some work suggests that together rs-fMRI and task-fMRI paradigms contribute to understanding the neural basis of disorders, such as schizophrenia, and behavior, like sense of self and response time (Du et al, 2012; Kelly et al, 2008; Qin and Northoff, 2011). Multimodal imaging may also be useful in predicting outcomes like substance use treatment completion and rearrest (Fink et al, 2016; Steele et al, 2015). Overall, these approaches may contribute distinct utility for use in patient groups.…”

Section: Introductionmentioning

confidence: 99%

Resting state connectivity best predicts alcohol use severity in moderate to heavy alcohol users

Fede

Grodin

Dean

et al. 2019

NeuroImage: Clinical

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Background In the United States, 13% of adults are estimated to have alcohol use disorder (AUD). Most studies examining the neurobiology of AUD treat individuals with this disorder as a homogeneous group; however, the theories of the neurocircuitry of AUD call for a quantitative and dimensional approach. Previous imaging studies find differences in brain structure, function, and resting-state connectivity in AUD, but few use a multimodal approach to understand the association between severity of alcohol use and the brain differences. Methods Adults (ages 22–60) with problem drinking patterns ( n = 59) completed a behavioral and neuroimaging protocol at the National Institutes of Health. Alcohol severity was quantified with the Alcohol Use Disorders Identification Test (AUDIT). In a 3 T MRI scanner, participants underwent a structural MRI as well as resting-state, monetary incentive delay, and face matching fMRI scans. Machine learning was applied and trained using the neural data from MRI scanning. The model was tested for generalizability in a validation sample ( n = 24). Results The resting state-connectivity features model best predicted AUD severity in the naïve sample, compared to task fMRI, structural MRI, combined MRI features, or demographic features. Network connectivity features between salience network, default mode network, executive control network, and sensory networks explained 33% of the variance associated with AUDIT in this model. Conclusions These findings indicate that the neural effects of AUD vary according to severity. Our results emphasize the utility of resting state fMRI as a neuroimaging biomarker for quantitative clinical evaluation of AUD.

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“…Nearly 25% of Americans reporting a lifetime drug dependence also report cocaine dependence (Grant et al, 2016). This chronic, relapsing brain disease is characterized by dysregulated circuits related to cue reactivity, reward processing, executive control, and intrinsic network connectivity (Garavan et al, 1999, 2000; Gu et al, 2010; Steele et al, 2014, 2017, 2018a, 2019; Hu et al, 2015; Fedota et al, 2016; Fink et al, 2016; McHugh et al, 2016). Low retention (∼42%) and high relapse (∼70%) rates plague current treatments for cocaine use disorder (CUD; Dutra et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Accelerated Intermittent Theta-Burst Stimulation as a Treatment for Cocaine Use Disorder: A Proof-of-Concept Study

et al. 2019

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There are no effective treatments for cocaine use disorder (CUD), a chronic, relapsing brain disease characterized by dysregulated circuits related to cue reactivity, reward processing, response inhibition, and executive control. Transcranial magnetic stimulation (TMS) has the potential to modulate circuits and networks implicated in neuropsychiatric disorders, including addiction. Although acute applications of TMS have reduced craving in urine-negative cocaine users, the tolerability and safety of administering accelerated TMS to cocaine-positive individuals is unknown. As such, we performed a proof-of-concept study employing an intermittent theta-burst stimulation (iTBS) protocol in an actively cocaine-using sample. Although our main goal was to assess the tolerability and safety of administering three iTBS sessions daily, we also hypothesized that iTBS would reduce cocaine use in this non-treatment seeking cohort. We recruited 19 individuals with CUD to receive three open-label iTBS sessions per day, with approximately a 60-min interval between sessions, for 10 days over a 2-week period (30 total iTBS sessions). iTBS was delivered to left dorsolateral prefrontal cortex (dlPFC) with neuronavigation guidance. Compliance and safety were assessed throughout the trial. Cocaine use behavior was assessed before, during, and after the intervention and at 1- and 4-week follow-up visits. Of the 335 iTBS sessions applied, 73% were performed on participants with cocaine-positive urine tests. Nine of the 14 participants who initiated treatment received at least 26 of 30 iTBS sessions and returned for the 4-week follow-up visit. These individuals reduced their weekly cocaine consumption by 78% in amount of dollars spent and 70% in days of use relative to pre-iTBS cocaine use patterns. Similarly, individuals reduced their weekly consumption of nicotine, alcohol, and THC, suggesting iTBS modulated a common circuit across drugs of abuse. iTBS was well-tolerated, despite the expected occasional headaches. A single participant developed a transient neurological event of uncertain etiology on iTBS day 9 and cocaine-induced psychosis 2 weeks after discontinuation. It thus appears that accelerated iTBS to left dlPFC administered in active, chronic cocaine users is both feasible and tolerable in actively using cocaine participants with preliminary indications of efficacy in reducing both the amount and frequency of cocaine (and other off target drug) use. The neural underpinnings of these behavioral changes could help in the future development of effective treatment of CUD.

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Brain potentials predict substance abuse treatment completion in a prison sample

Cited by 28 publications

References 43 publications

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Resting state connectivity best predicts alcohol use severity in moderate to heavy alcohol users

Accelerated Intermittent Theta-Burst Stimulation as a Treatment for Cocaine Use Disorder: A Proof-of-Concept Study

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