CMOS LIF detection system for capillary analysis

Pittet, Patrick; Galvan, Jean‐Marc; Lu, Guo‐Neng; Blum, Loı̈c J.; Leca‐Bouvier, Béatrice D.

doi:10.1016/j.snb.2003.09.021

Cited by 9 publications

(7 citation statements)

References 12 publications

(14 reference statements)

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“…In biomedical and chemical applications [5,8,10,13,[21][22][23][24][25][26][27][28][29][30], quantitative spectral analysis is often needed. As illustrated from Fig.…”

Section: Applicationsmentioning

confidence: 99%

“…7 (i.e., 0, x jθ and x sub ); S PHjθ denote the diffusion spectral sensitivities. From equations (8) and (11), (7) can be rewritten as:…”

Section: B Diffusion Componentsmentioning

confidence: 99%

“…Basic CMOS and BiCMOS processes have allowed implementation of buried double junction (BDJ) and buried triple p-n junction (BTJ) device structures [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. Using an advanced CMOS technology, we can design and integrate a buried quad junction (BQJ) photodetector for specific applications [23][24][25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

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A CMOS Buried Quad p-n Junction Photodetector Model

et al. 2016

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International audienceA buried quad junction (BQJ) photodetector has been designed and fabricated with a high-voltage CMOS process. It implements four vertically-stacked p-n junctions with four different spectral responses. This feature allows high spectral discriminating ability, greater than both conventional buried double junction and buried triple junction detectors. In this paper, we propose a SPICE-like model, based on the physical properties of the device structure. The proposed model has been integrated in EDA software. It could be used for rapid and reliable design of system on chip, integrating the BQJ sensor, and its signal processing. The analytical expressions of the four BQJ photocurrents, as well as dark currents, have been developed. The spectral characteristics of the photodetector, computed with the proposed model, have been compared with those from TCAD simulations and experimental measurements. The analytical is close to the measurement with an average error on spectral responses in the range of 3-17 %, depending on the considered junction

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“…In biomedical and chemical applications [5,8,10,13,[21][22][23][24][25][26][27][28][29][30], quantitative spectral analysis is often needed. As illustrated from Fig.…”

Section: Applicationsmentioning

confidence: 99%

“…7 (i.e., 0, x jθ and x sub ); S PHjθ denote the diffusion spectral sensitivities. From equations (8) and (11), (7) can be rewritten as:…”

Section: B Diffusion Componentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A CMOS Buried Quad p-n Junction Photodetector Model

et al. 2016

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“…The chip of Figure 21a was used for capillary fluorescence detection. The evaluated limit of detection was below 10 -10 M in fluorescein isothiocyanate (FITC) concentration for a small volume of 5 nL [114]. …”

Section: Examples Of Applications In Integrated Cmos Optical Sensorsmentioning

confidence: 99%

A Review of the CMOS Buried Double Junction (BDJ) Photodetector and its Applications

Feruglio

Garda

et al. 2008

Sensors

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A CMOS Buried Double Junction PN (BDJ) photodetector consists of two vertically-stacked photodiodes. It can be operated as a photodiode with improved performance and wavelength-sensitive response. This paper presents a review of this device and its applications. The CMOS implementation and operating principle are firstly described. This includes the description of several key aspects directly related to the device performances, such as surface reflection, photon absorption and electron-hole pair generation, photocurrent and dark current generation, etc. SPICE modelling of the detector is then presented. Next, design and process considerations are proposed in order to improve the BDJ performance. Finally, several BDJ-detector-based image sensors provide a survey of their applications.

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“…Electronic mail: michal.pribyl@vscht.cz. induced fluorescence ͑LIF͒ systems͔, 8,9 ͑ii͒ lamp-based excitation systems that are usually less expensive and less efficient than lasers, 10,11 and ͑iii͒ light-emitting diodes that are cheap and small; however, their beam spectra are wider than the laser spectra. 12 Recent progress in the laser technology has produced stable laser sources that cover a wide range of wavelengths from ultraviolet to infrared region.…”

Section: Introductionmentioning

confidence: 99%

Detection of immunoglobulins in a laser induced fluorescence system utilizing polydimethysiloxane microchips with advanced surface and optical properties

et al. 2011

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We developed an automated laser induced fluorescence system utilizing microfluidic chips for detection and quantification of immunoglobulins. Microchips were fabricated from polydimethysiloxane ͑PDMS͒ using the so-called "prepolymerization technique." The microchip structure helped minimize the effects of PDMS autofluorescence and light scattering. Furthermore, a thin and uniform PDMS layer forming the top of the microchip enabled proper focusing and collection of the excitation beam and the emitted fluorescence, respectively. The developed system was tested for the detection of mouse immunoglobulins. The capturing antibodies were immobilized on internal microchannel walls in the form of a polyelectrolyte. We clearly show that this immobilization technique, if correctly realized, gives results with high reproducibility. After sample incubation and washing, secondary antibodies labeled by fluorescein isothiocyanate were introduced into microchannels to build a detectable complex. We show that mouse antibodies can be quantified in a wide concentration range, 0.01-100 g ml −1 . The lower detection limit was below 0.001 g ml −1 ͑6.7 pM͒. The developed laser induced fluorescence ͑LIF͒ apparatus is relatively cheap and easy to construct. The total cost of the developed LIF detector is lower than a typical price of plate readers. If compared to classical ELISA ͑enzyme linked immunosorbent assay͒ plate systems, the detection of immunoglobulins or other proteins in the developed PDMS microfluidic device brings other important benefits such as reduced time demands ͑10 min incubation͒ and low reagent consumption ͑less than 1 l͒. The cost of the developed PDMS chips is comparable with the price of commercial ELISA plates. The main troubleshooting related to the apparatus development is also discussed in order to help potential constructors.

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CMOS LIF detection system for capillary analysis

Cited by 9 publications

References 12 publications

A CMOS Buried Quad p-n Junction Photodetector Model

A CMOS Buried Quad p-n Junction Photodetector Model

A Review of the CMOS Buried Double Junction (BDJ) Photodetector and its Applications

Detection of immunoglobulins in a laser induced fluorescence system utilizing polydimethysiloxane microchips with advanced surface and optical properties

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