The proposed HDR-BT phantom and instrumented applicator have been tested and their main characteristics have been evaluated. These systems perform unsupervised measurements and analysis without prior treatment plan information. They allow independent verification of dwell position and time with accuracy of measurements comparable with other similar systems reported in the literature.
Seeded batch crystallizations of monohydrate citric acid were performed under isothermal conditions (15 °C).
Continuous monitoring of the overall solid concentration during the crystallization process was developed using in situ Raman
spectroscopy. Quantitative estimation of the crystal size distribution (CSD) was made possible thanks to in situ image acquisition:
off-line CSD measurements were further computed from the recorded pictures. The growth rate of monohydrate citric acid was
estimated from solid concentration. Through in situ particle size visualization and quantitative analysis of the pictures, activated
surface secondary nucleation was also shown to significantly impact the final CSD. It is underlined that, in addition to continuous
Raman in situ spectroscopic concentration measurements, image acquisition yields highly valuable data on the dispersed phase.
Advantages and drawbacks of the technique for the monitoring of solution crystallization are discussed.
The process of encapsulation by complex coacervation includes several steps that have been investigated in order to reach a better control over the whole process. This has been carried out for the encapsulation of linseed oil by the classical gelatin/acacia gum pair of coacervating polymers. Fabrication of an oil‐in‐water emulsion is the first step that has been studied so as to reach a definite picture of the emulsification process under intermediate flow regime in a stirred unbaffled vessel. The classical scheme of oil droplet break‐up by turbulent eddies in the turbulent inertial regime gave a fair agreement with the experiments and can be used as a possible framework for a process scale‐up. Polynuclear microcapsules containing several oil droplets have been obtained during the deposition of the coacervate onto the surface of oil droplets. According to the emulsification conditions and microparticles growth caused by multiple droplets encapsulation, microcapsules of ∼130 µm were produced. A video probe immersed in the stirred vessel allowed an in situ monitoring of the successive events taking place as acid was added into the medium. This technique allows dynamic observations of microcapsules formation. These observations confirmed the deposition of coacervate droplets around oil drops and clearly showed that the formation of coacervate particles and their deposition onto oil droplets were successive events.
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