Crystallization-in-emulsion process of a melted organic compound: In situ optical monitoring and simultaneous droplet and particle size measurements

Khalil, Abir; Puel, François; Cosson, Xavier; Gorbatchev, Olga; Chevalier, Yves; Galvan, Jean‐Marc; Rivoire, Alain; Klein, Jean‐Paul

doi:10.1016/j.jcrysgro.2011.06.005

Cited by 14 publications

(16 citation statements)

References 34 publications

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“…They are implied within http://dx.doi.org/10.1016/j.cej.2014.08.014 different processes including liquid-liquid extraction [1], crystallization [2][3][4] or polymerization to control final particle or latex properties [5,6]. For such separation techniques or reactions, it is crucial to control accurately the dispersion because it is directly related to efficiency of processes.…”

Section: Introductionmentioning

confidence: 99%

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Lobry

Lasuye²,

Gourdon

et al. 2015

Chemical Engineering Journal

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible.Liquid-liquid dispersion in a continuous oscillatory baffled reactor -Application to suspension polymerization b s t r a c tReducing energy costs, improving safety, minimizing waste are the current aims of chemical engineering. Process intensification in fine chemistry has been extensively studied but less work refers to heterogeneous reactions involving two liquid phases. This paper focuses on batch to continuous suspension polymerization transposition and especially on the liquid-liquid dispersion step. The main features of suspension polymerization reaction are based on (i) the initial liquid-liquid dispersion requiring a controlled size and narrow distribution and (ii) on the control of the final particle size during the agglomeration step by avoiding fouling which is a bottleneck for continuous flow. For the continuous transposition, liquid-liquid dispersion and reaction studies are carried out in continuous oscillatory baffled reactor (COBR) which is a multipurpose reactor. Its suitability to overcome the bottlenecks is demonstrated through the investigation of the oscillating and flow conditions or the dispersed phase holdup. A controlled droplet size distribution can be achieved. Oscillation is the main parameter responsible for droplet breakage. The suitable conditions to obtain stable dispersion are determined. For one of the first times, COBR is used for suspension polymerization.

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Section: Introductionmentioning

confidence: 99%

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Lobry

Lasuye²,

Gourdon

et al. 2015

Chemical Engineering Journal

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“…The crystallization process is based on the formation of crystallization nuclei understood as material points of the solid phase, followed by the growth of nuclei and the creation of a super-particular structure in the given system in the time t. It is worth noting that the differentiation and separation of the nucleation process (the formation of nuclei) from the nucleic growth process still remains a subject of research (Khalil et al, 2012). So far, crystallization kinetics has been widely studied in research on polymers (Lu et al, 1998;Martins & Cruz Pinto, 2002;Krumme et al, 2004), alloys (Vázquez et al, 2000;Liu et al, 2002), kaolinite (Fiore et al, 2011), oil-in-water emulsion (Khalil et al, 2012) or even milk fat fraction and chocolate (Herrera et al, 1999;Fernandes et al, 2013).…”

Section: Crystallization Processmentioning

confidence: 99%

“…So far, crystallization kinetics has been widely studied in research on polymers (Lu et al, 1998;Martins & Cruz Pinto, 2002;Krumme et al, 2004), alloys (Vázquez et al, 2000;Liu et al, 2002), kaolinite (Fiore et al, 2011), oil-in-water emulsion (Khalil et al, 2012) or even milk fat fraction and chocolate (Herrera et al, 1999;Fernandes et al, 2013). The general Avrami equation was applied in the process of crystals formation of any shape and uses substitute spherical diameters.…”

Section: Crystallization Processmentioning

confidence: 99%

“…What is more, for studies on the crystallization of non-isothermal and isothermal conditions thermal analysis and techniques such as DSC (Differential Scanning Calorimetry) have become more popular (Lorenzo et al, 2007;Ovono Ovono et al, 2012). According to Khalil et al (2012) and Stelzer et al (2013), tests on the formation of crystals can be also carried out with use of light transmittance, polarized light microscopy, viscosimetry, diffusive light scattering, time-resolved synchrotron X-ray diffraction, ultrasound velocity measurements and laser-polarized light turbidimetry.…”

Section: Crystallization Processmentioning

confidence: 99%

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Using Avrami equation in the studies on changes in granulometric composition of algal suspension

Kuśnierz

Łomotowski

2015

Hydrobiologia

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In recent years, it has been recognized that the laser diffraction gives valuable information on particle size distribution for all types of dry inorganic or even organic materials. With use of the laser diffraction and the laser granulometer, this paper presents the changes occurring in the granulometric distribution of algal agglomerates and the changes in values of percentiles 10, 50 and 90%, determined basing on volume distribution. While assessing the granulometric composition, the existence of a proportional relationship between the diameter values corresponding to the percentile of 10, 50 and 90% was observed. What is more, the obtained results give insight into the possibility of application of the general Avrami equation to describe the granulometric composition of the algal suspension through the analogy of crystals formation from saturated solutions. The analysis shows that the model described by the modified Avrami equation adequately matched the regression to the experimental data on the granulometric composition of algal suspensions. The values of the correlation coefficients were close to 1, which proves that the regression model explained nearly all cases by the dependent variable V i = F(d i ).

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“…In order to aerosolize the drug particles, the properties of both the carriers and the API particles are of great importance since the drug-carrier adhesive forces need to be overcome by the patient's inspiratory force [4]. Studies have reported on the impact of particle mean size [5], particle size distribution [6], morphology [7,8], crystal form [9], surface roughness [10] and surface energy [11] on the performance of inhalable dry powders. Indeed, the particle size, size distribution, morphology and polymorphism of carriers have been found to exert a major impact on the efficiency of dry powder inhalation (DPI) [12,13], although results have not been consistent.…”

Section: Introductionmentioning

confidence: 99%

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

Lyu

Liu

Zhang

et al. 2017

Journal of Crystal Growth

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The morphology and polymorphism of mannitol particles were controlled during spray drying with the aim of improving the aerosolization properties of inhalable dry powders. The obtained microparticles were characterized using scanning electron microscopy, infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction and inhaler testing with a next generation impactor. Mannitol particles of varied -mannitol content and surface roughness were prepared via spray drying by manipulating the concentration of NH 4 HCO 3 in the feed solution. The bubbles produced by NH 4 HCO 3 led to the formation of spheroid particles with a rough surface. Further, the fine particle fraction was increased by the rough surface of carriers and the high -mannitol content.Inhalable dry powders with a 29.1 ± 2.4% fine particle fraction were obtained by spray-drying using 5% mannitol (w/v)/2% NH 4 HCO 3 (w/v) as the feed solution, proving that this technique is an effective method to engineer particles for dry powder inhalation.

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Crystallization-in-emulsion process of a melted organic compound: In situ optical monitoring and simultaneous droplet and particle size measurements

Cited by 14 publications

References 34 publications

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Liquid–liquid dispersion in a continuous oscillatory baffled reactor – Application to suspension polymerization

Using Avrami equation in the studies on changes in granulometric composition of algal suspension

Combined control of morphology and polymorph in spray drying of mannitol for dry powder inhalation

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