Pulse oximetry enables oxygen saturation estimation ( S p O 2) non-invasively in real time with few components and modest processing power. With the advent of affordable development kits dedicated to the monitoring of biosignals, capabilities once reserved to hospitals and high-end research laboratories are becoming accessible for rapid prototyping. While one may think that medical-grade equipment differs greatly in quality, surprisingly, we found that the performance requirements are not widely different from available consumer-grade components, especially regarding the photodetection module in pulse oximetry. This study investigates how the use of candidate light sources and photodetectors for the development of a custom S p O 2 monitoring system can lead to inaccuracies when using the standard computational model for oxygen saturation without calibration. Following the optical characterization of selected light sources, we compare the extracted parameters to the key features in their respective datasheet. We then quantify the wavelength shift caused by spectral pairing of light sources in association with photodetectors. Finally, using the widely used approximation, we report the resulting absolute error in S p O 2 estimation and show that it can lead up to 8% of the critical 90–100% saturation window.
International audienceA buried quad junction (BQJ) photodetector has been designed and fabricated with a high-voltage CMOS process. It implements four vertically-stacked p-n junctions with four different spectral responses. This feature allows high spectral discriminating ability, greater than both conventional buried double junction and buried triple junction detectors. In this paper, we propose a SPICE-like model, based on the physical properties of the device structure. The proposed model has been integrated in EDA software. It could be used for rapid and reliable design of system on chip, integrating the BQJ sensor, and its signal processing. The analytical expressions of the four BQJ photocurrents, as well as dark currents, have been developed. The spectral characteristics of the photodetector, computed with the proposed model, have been compared with those from TCAD simulations and experimental measurements. The analytical is close to the measurement with an average error on spectral responses in the range of 3-17 %, depending on the considered junction
The usual imaging techniques providing only limited information, there is an unmet need for methods, firstly, to monitor in real time the functional status of the Spinal Cord (SC) and, secondly, to assess the functional consequences of the SC Injuries (SCI) and the effect of therapeutic interventions. To meet these needs, our project aims to investigate a new imaging approach, through the realization of a device for measuring the SC activity. This approach will establish locally and specifically the functional state of the SC in real time, which will provide a breakthrough in surgery, as well as in the care and therapeutic trials for SCI. This paper presents the first results of this research project on pig subjects, focusing on the opto-electrical part, based on Near-InfraRed Spectroscopy (NIRS). Firstly, the pig SC optical characterization was performed in different conditions, using a portable spectrophotometer in order to define the wavelengths of interest and their corresponding optical attenuation. In transmission mode, the Optical Density (OD) was evaluated between 3.5 and 6.5 in the [500; 950] nm range. In reflection mode, a figure between 11 % and 33 % is obtained in the same wavelength range. We find that wavelengths between 600 nm and 940 nm are good candidates to monitor the SC functional activity. Secondly, thanks to these results, a specific opto-electrical system has been designed for the transmission mode only, with adapted light sources and custom probes with its front-end to observe the autonomic functions in the SC. 2Results on the measured haemodynamic variations, at rest and under stimulation, show in real time the impact of a global stimulus on a local section of the SC. However, with a low AC-to-DC ratio (around 1 %), the SC PhotoPlethysmoGram (PPG) acquisition isn't simple and the best trade-off between power consumption and Signal-to-Noise Ratio (SNR) must be found in the perspective of the Embedded System (ES) development.This study demonstrates, for the first time, the feasibility of the SC activity monitoring using NIRS in transmission mode in a big animal model, where the perfect alignment of the light emitter and receptor isn't necessary due to the diffusive property of the biological media.It contributes to heading towards the use of the Internet of Things (IoT) for medical applications, through the monitoring of the SC during highly invasive processes, such as the stabilization of the spine, in the form of implants and other surgeries, such as that of the aorta, with the use of specific minimally invasive catheters.
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