Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Halfon, Belkıs; Çetin, Özlem; Kökdil, Gamze; Topçu, Gülaçtı

doi:10.25135/rnp.99.18.05.291

Cited by 9 publications

(7 citation statements)

References 22 publications

(34 reference statements)

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“…capacity in parallel with the literature. As indicated the literature, Salvia species exhibit strong antioxidant activity due to their rosmarinic acid content (Halfon, Cetin, Kokdil, & Topcu, 2019;Topcu et al, 2007). There are many studies in the literature regarding the high antioxidant potential of rosmarinic acid (Ertas et al, 2014;Ertas Yilmaz & Firat, 2015).…”

Section: Toxic-cytotoxic and Antioxidant Activitiesmentioning

confidence: 68%

A GC–MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & C.A. Mey. of Turkey: Enzyme inhibitory potential of ferruginol

Bakir¹,

Akdeniz²,

Ertaş

et al. 2020

J Food Biochem

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In the present study, a GC‐MS method used for quantitative screening of 26 compounds (sclareolide, sclareol, ferruginol, cryptanol, 6,7‐dehydroroyleanone, suginal, 9,10‐dihydro‐7,8‐dimethyl‐2‐(1‐methylethyl) phenanthren‐3‐ol, sugiol, inuroyleanone, 12‐demethylmulticauline, 7α‐hydroxy‐β‐sitosterol, stigmasterol, sitosterol, salvigenin, sinensetin, α‐amyrin, lupeol, lupenone, 3‐acetyl lupeol, 1α,21α‐dihydroxy‐2,3‐(1′1′‐dimethyl‐dioxymethylene) urs‐9(11),12‐dien, uvaol, betulin, pyxinol, lup‐(20),29‐ene‐2α‐hydroxy‐3β‐acetate, betulin 3β, 28β‐diacetate, 21α‐hydroxy,2α,3β‐diacetoxy urs‐9(11),12‐dien) specific to Turkish Salvia species was developed and validated. According to the GC–MS analysis results, Salvia hypargeia Fisch. & C.A. Mey. roots were found to be rich in ferruginol (30787.97 µg/g extract) and lupenone (23276.21 µg/g extract), and leaves in lupeol (20625.92 µg/g extract). Additionally, the essential oil and aroma contents of this species were identified by GC‐MS technique. According to the LC‐MS/MS results, especially S. hypargeia leaf extract was rich in rosmarinic acid (38035.7 µg/g extract) and isoquercitrin (4136.91 µg/g extract). Furthermore, anticholinesterase, antiurease, antityrosinase and antielastase inhibitory, antioxidant, cytotoxic activities of the ethanol extracts, essential oil, and major components of the species were evaluated. Antioxidant potentials of all extracts of this species were quite high in all studied antioxidant methods. Moreover, butyrylcholinesterase and elastase inhibitory capacities of ferruginol, the major component of S. hypargeia roots, were notable. For these reasons, this species has a high potential for food and pharmaceutical industries. Practical applications This new GC–MS method was applied to S. hypargeia Fisch. & C.A. Mey. and it indicated that this species possessed high amount of ferruginol and lupeol, and that this species could be used for their natural sources. According to the results of the activity studies (antioxidant, anticholinesterase, tyrosinase, elastase, and cytotoxic), this method was used to exhibit which compound may be responsible for the activities. This developed and validated method could be easily applied to determine major/active/toxic secondary metabolites of Salvia species which are used and/or could be used in pharmaceutical, cosmetic, and food industries.

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Section: Toxic-cytotoxic and Antioxidant Activitiesmentioning

confidence: 68%

A GC–MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & C.A. Mey. of Turkey: Enzyme inhibitory potential of ferruginol

Bakir¹,

Akdeniz²,

Ertaş

et al. 2020

J Food Biochem

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“…The best ionization of small and relatively polar compounds has been achieved with the ESI source. The ions between m / z 85–1500 were scanned in high-resolution mode of instrument [ 104 , 105 ]. Identification of the compounds was accomplished by comparing the retention times of the standard compounds (in the purity range of 95–99%; see section chemicals) and HRMS data of Bezmialem Vakif University, Drug Application and Research Center Library (ILMER).…”

Section: Methodsmentioning

confidence: 99%

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

et al. 2021

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Kınkor (Ferulago stellata) is Turkish medicinal plant species and used in folk medicine against some diseases. As far as we know, the data are not available on the biological activities and chemical composition of this medicinal plant. In this study, the phytochemical composition; some metabolic enzyme inhibition; and antidiabetic, anticholinergic, and antioxidant activities of this plant were assessed. In order to evaluate the antioxidant activity of evaporated ethanolic extract (EEFS) and lyophilized water extract (WEFS) of kınkor (Ferulago stellata), some putative antioxidant methods such as DPPH· scavenging activity, ABTS•+ scavenging activity, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+)-binding activities were separately performed. Furthermore, ascorbic acid, BHT, and α-tocopherol were used as the standard compounds. Additionally, the main phenolic compounds that are responsible for antioxidant abilities of ethanol and water extracts of kınkor (Ferulago stellata) were determined by liquid chromatography-high-resolution mass spectrometry (LC-HRMS). Ethanol and water extracts of kınkor (Ferulago stellata) demonstrated effective antioxidant abilities when compared to standards. Moreover, ethanol extract of kınkor (Ferulago stellata) demonstrated IC50 values of 1.772 μg/mL against acetylcholinesterase (AChE), 33.56 ± 2.96 μg/mL against α-glycosidase, and 0.639 μg/mL against α-amylase enzyme respectively.

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“…This high antioxidant property of the cultivated samples was in parallel with both total phenolic and LC-MS/MS results. In the results of the previous studies, there has a lot of information about the antioxidant properties of S. macrantha extracts, especially compounds such as rosmarinic acid, caffeic acid, hesperidin, astragalin, naringenin and luteolin were determined as very high antioxidative compounds [37,38]. Therefore, the high antioxidant potential of the culture samples could be related with these phenolic compounds.…”

Section: A B B Bmentioning

confidence: 99%

Biological and Chemical Comparison of Natural and Cultivated Samples of Satureja macrantha C.A.Mey.

Akdeniz¹,

Yener²,

Ertaş³

et al. 2021

Rec.Nat.Prod.

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In this study, investigation on the essential oils and ethanol extracts of naturally grown and cultivated Satureja macrantha samples were reported. The essential oil, flavour and terpenoid-steroid-flavonoid contents of S. macrantha samples were determined by GC-MS and their phenolic contents by LC-MS/MS. Besides, the biological activities of the samples were investigated for their antioxidant, anti-Alzheimer, antimicrobial, cytotoxic, antityrosinase, antiurease, antielastase and anticollagenase properties. The phenolic content and antioxidant capacity of the cultivated sample were higher than those of the naturally grown sample. According to the GC-MS results, terpinene-4-ol (30.9%) and p-cymene (56.7%) were determined as the major components in the essential oils of the naturally grown and cultivated S. macrantha, respectively. The flavour analysis results showed that cis-sabinene hydrate (20.7%) and carvacrol (42.2%) were found to be the major components in the naturally grown and cultivated samples, respectively. While the naturally grown sample was rich in abietane diterpenoids (ferruginol (17.5 mg analyte/g extract) and sugiol (4.2 mg analyte/g extract)), these components were not detected in the cultivated sample. The rosmarinic acid content (0.20 and 24.87 mg analyte/g extract, respectively) of the cultivated sample was found to be significantly higher than that of the natural sample. The biological activities of the samples were determined to be changed in parallel with their chemical contents that are due to factors such as climatic conditions, and soil structure.

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Chemical Investigation and Bioactivity Screening of Salvia cassia Extracts

Cited by 9 publications

References 22 publications

A GC–MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & C.A. Mey. of Turkey: Enzyme inhibitory potential of ferruginol

A GC–MS method validation for quantitative investigation of some chemical markers inSalvia hypargeiaFisch. & C.A. Mey. of Turkey: Enzyme inhibitory potential of ferruginol

LC-HRMS Profiling and Antidiabetic, Anticholinergic, and Antioxidant Activities of Aerial Parts of Kınkor (Ferulago stellata)

Biological and Chemical Comparison of Natural and Cultivated Samples of Satureja macrantha C.A.Mey.

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