Association Between Elevated Serum Uric Acid and Vitamin D Insufficiency Among the Middle-Aged and Elderly Population

Takır, Mümtaz; Solak, Yalçın; Erek, Aybala; Köstek, Osman; Oral, Alihan; Elçioğlu, Ömer Celal; Bakan, Ali; Afsar, Barış; Özkök, Abdullah; Jalal, Diana; Johnson, Richard J.; Bahat, Kübra Aydın; Odabaş, Ali Rıza; Kanbay, Mehmet

doi:10.5262/tndt.2016.1002.10

Cited by 10 publications

(17 citation statements)

References 15 publications

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“…Among 32 studies, 21 28 29 30 31 32 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 and 11 23 24 25 26 27 60 61 62 63 64 65 considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6 31 32 44 48 49 50 provided data of SUA and VIT D levels as continuous variables, 14 28 29 30 31 32 45 46 47 49 52 53 54 57 59 assessed association between SUA level as continuous data and categorical VIT D status, while 3 55 56 58 provided categorical data for both.…”

Section: Resultsmentioning

confidence: 99%

“…Within the 21 studies with VIT D outcome, 6 31 32 44 48 49 50 provided data of SUA and VIT D levels as continuous variables, 14 28 29 30 31 32 45 46 47 49 52 53 54 57 59 assessed association between SUA level as continuous data and categorical VIT D status, while 3 55 56 58 provided categorical data for both. For the 11 studies with SUA outcome, 1 64 had continuous data for both VIT D and SUA levels, 9 23 24 25 27 60 61 62 63 65 provided continuous data for VIT D level and categorical SUA status, and 2 25 26 provided categorical data for both.…”

Section: Resultsmentioning

confidence: 99%

“…However, this description might only explain a part of the bigger picture, since there are several other factors which could affect VIT D level such as diet, BMI, age, gender, geographical location, and season [21]. Meanwhile, for the association between VIT D and SUA outcome, the results from pooling ORs [25,26,55,56,58] showed a significant association between VIT D deficiency and hyperuricemia. This pooled OR is inconsistent with the above-mentioned pooled beta coefficient of SUA on serum 25(OH)D level.…”

Section: Discussionmentioning

confidence: 98%

“…Previous evidence [23][24][25][26][27] showed that VIT D deficiency might increase the risk of high serum uric acid (SUA). On the other hand, some studies [28][29][30][31][32] showed that high SUA (hyperuricemia) could decrease VIT D level and/or induce VIT D deficiency.…”

Section: Introductionmentioning

confidence: 99%

“…Most of them(23) were crosssectional studies. Their participants were either from the general population or had specific diseases, with mean age ranging from 36.9 to 76.9 years.Among 32 studies, 21[28][29][30][31][32][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] and 11[23][24][25][26][27][60][61][62][63][64][65] considered VIT D and SUA as the outcome, respectively. Within the 21 studies with VIT D outcome, 6[31,32,44,[48][49][50] provided data of SUA and VIT D levels as continuous variables, 14…”

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confidence: 99%

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Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

et al. 2020

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Association between vitamin D and uric acid is complex and might be bidirectional. Our study aimed to determine the bidirectional association between vitamin D and uric acid in adults. Using MEDLINE via PubMed and Scopus, we systematically searched for observational or interventional studies in adults, which assessed the association between serum vitamin D and serum uric acid, extracted the data, and conducted analysis by direct and network meta-analysis. The present review included 32 studies, of which 21 had vitamin D as outcome and 11 had uric acid as outcome. Meta-analysis showed a significant pooled beta coefficient of serum uric acid level on serum 25(OH)D level from 3 studies of 0.512 (95% confidence interval: 0.199, 0.825) and a significant pooled odds ratio between vitamin D deficiency and hyperuricemia of 1.496 (1.141, 1.963). The pooled mean difference of serum 25(OH)D between groups with hyperuricemia and normouricemia was non-significant at 0.138 (−0.430, 0.707) ng/ml, and the pooled mean difference of serum uric acid between categories of 25(OH)D were also non-significant at 0.072 (−0.153, 0.298) mg/dl between deficiency and normal, 0.038 (−0.216, 0.292) mg/dl between insufficiency and normal, and 0.034 (−0.216, 0.283) mg/dl between deficiency and insufficiency. In conclusion, increasing serum uric acid might be associated with increasing 25(OH)D level, while vitamin D deficiency is associated with hyperuricemia. These reverse relationships should be further evaluated in a longitudinal study.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

et al. 2020

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Association between serum uric acid and bone health in adolescents

2019

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Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid and Hypertension in New Onset Diabetic Patients: A Cross-Sectional Indian Study

Singh¹,

Singh²,

Singh³

et al. 2022

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Objective Prevalence of hyperuricemia (HU) is increasing and it is associated with hypertension, metabolic syndrome, diabetes mellitus (DM), obesity, chronic kidney disease, gout and cardiovascular disease. Elevated level of serum uric acid (SUA) has been shown to be associated with hypertension and diabetes in many countries but there is lack of evidence from India. The aim of this study is to know the prevalence of HU and to know the relationship between SUA and hypertension in newly onset DM. Methods This is a cross-sectional study from a tertiary center. A total of 305 (males: 212; females: 93) newly diagnosed diabetic patients were enrolled. All patients were categorized as normotensive (<140/90) and hypertensive (≥140/90) based on ADA criteria. Based on SUA level participants were grouped into 3 tertile (T1: <4.52; T2: 4.52–5.64; T3: >5.64 mg/dl). Results The mean age, systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the patients were 46.76 ±0.61 years, 130.6±1.06 mmHg and 84.11±0.63 mmHg, respectively. The mean level of SUA was 5.14±0.073 mg/dl and level was significantly higher in males compared with females (P <0.000). Overall prevalence of HU and hypertension was 12.13% and 44.59%, respectively. There was an increase in the prevalence of hypertension across the SUA tertile. SBP and DBP significantly increased across the SUA tertile (P <0.014 and <0.001, respectively). A multiple logistic regression analysis revealed that SUA tertile was independently associated with presence of hypertension (P <0.01). Conclusion This first report on the population of the eastern part of India indicates a significant positive relationship between SUA and hypertension among the newly onset Indian diabetic patients. Therefore, routine measurement of SUA is recommended in newly onset hypertensive diabetic patients to prevent HU and its related complications.

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Association Between Elevated Serum Uric Acid and Vitamin D Insufficiency Among the Middle-Aged and Elderly Population

Cited by 10 publications

References 15 publications

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

Association between serum uric acid and bone health in adolescents

Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid and Hypertension in New Onset Diabetic Patients: A Cross-Sectional Indian Study

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