Association between serum uric acid and bone health in adolescents

Karimi, Fariba; Dabbaghmanesh, Mohammad Hossein; Omrani, Gholamhossein Ranjbar

doi:10.1007/s00198-019-05072-w

Cited by 15 publications

(14 citation statements)

References 39 publications

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“…The study also confirmed no significant association between SUA and total body BMD in young adults, women, non-obese, and smokers. This finding is supported by several epidemiological studies using different study designs and population samples (23,24,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) as listed in Table 2. These epidemiological studies aimed to elucidate the relation between SUA and bone health.…”

Section: Discussionsupporting

confidence: 64%

“…These epidemiological studies aimed to elucidate the relation between SUA and bone health. Many cross-sectional studies have confirmed the positive association between SUA and BMD in both genders and all age groups after adjustment for potential confounders (28,36,38). In other cross-sectional studies, the positive association was dependant on a significant interaction of SUA level with age and vitamin C level (40), central adiposity, or obesity among postmenopausal women (23,24,26).…”

Section: Discussionmentioning

confidence: 92%

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Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

et al. 2021

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BackgroundOxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn’t draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris.MethodologyA cross-sectional analysis including total-body and site-specific bone mineral density scores and other serological markers of 2981 healthy Qatari adults (36.4 ± 11.1 years) from the Qatar biobank database was conducted. The study participants were divided into quartiles based on the level of SUA, and the BMD was measured using dual-energy X-ray absorptiometry (DXA). Multiple regression analyses were applied to investigate the association between SUA and BMD adjusting for multiple confounding factors.ResultsHigh levels of SUA were significantly associated with the increased bone mineral density of the total body and at site-specific skeletal locations after adjusting for age and gender (p-value < 0.001). Further adjustment for body mass index (BMI), smoking, vitamin D, alkaline phosphatase, and estimated glomerular filtration rate (eGFR) levels attenuated the association but the association remained significant for individuals with high SUA levels (p-value ≤ 0.01).The association between SUA and BMD was not significant in non-obese, females, young adults, and smokers. However, no interaction was found between SUA and age, gender, BMI and smoking.ConclusionHigher SUA levels are associated with a high bone density among healthy Qatari adults. However, such observation demands further investigations to outline the underlying mechanisms.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 92%

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

et al. 2021

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“…Recent studies have confirmed that uric acid is closely related to obesity ( 8 ), non-alcoholic fatty liver disease (NAFLD) ( 2 , 9 , 10 ), hypertension ( 11 , 12 ), and diabetes ( 1 , 3 ). SUA can even affect the bone metabolism of teenagers ( 13 ). However, a uniform reference range for children's uric acid hasn't been established yet in the world.…”

Section: Discussionmentioning

confidence: 99%

Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

et al. 2021

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Context: Hyperuricemia is defined when the plasma uric acid concentration is above 416 μmol/L (7 mg/dl) in male adults, or 357 μmol/L (6 mg/dl) in female adults. However, there are no explicit criteria yet for children.Objective: It is necessary to set up reference intervals for the uric acid level in different age groups among children.Materials and Methods: A total of 5,439 individuals (3,258 males, 2,181 females) were included in the final statistical analysis. Reference values of all age groups were determined by statistical descriptions. Multiple linear regression analysis was applied to determine the relationship between uric acid level, BMI, and age.Results: The level of uric acid increased with age. Gender differences in uric acid level occurred after the onset of puberty. Additionally, linear regression revealed a positive correlation between the uric acid level and BMI.Discussion and Conclusion: The reference range of the uric acid level in children is inconsistent with the previous viewpoint. Body mass index plays an important role in uric acid metabolism.

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“…Until now, evidence linking sUA and BMD in adolescents is very limited. To the best of our knowledge, only one report has focused on the relationship between sUA and BMD in adolescents, and the result of that cross-sectional study from Iran (221 girls and 192 boys) demonstrated a higher bone density in those who had higher UA levels (16). The prevalence of hyperuricemia in children and adolescents varies among countries, and largely depends on age, sex, ethnicity, and region (17).…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Uric Acid Status With Bone Mineral Density in Adolescents Aged 12–19 Years

et al. 2020

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Aims: Evidence linking serum uric acid (sUA) and bone mineral density (BMD) in adolescents is very limited. To the best of our knowledge, only one report has focused on the relationship between sUA and BMD in adolescents. Thus, this study aimed to determine the association between sUA and total BMD in adolescents aged 12-19 years.Methods: A cross-sectional study was conducted on a sample composed of non-institutionalized US population from the National Health and Nutrition Examination Survey. Weighted multivariate linear regression models were used to evaluate the association between sUA and total BMD. Subgroup analyses were further performed.Results: sUA positively correlated with total BMD in the multiple regression model after adjusting for potential confounders. However, in the subgroup analyses stratified by sex, age, or race/ethnicity, the association between sUA and total BMD followed an inverted U-shaped curve in female adolescents, adolescents aged 16-19 years, and other race/ethnicity. Conclusions: Our results suggested that the correlation between sUA level and total BMD differed by sex. The increased sUA level would be beneficial to bone health in adolescents with low sUA levels, but for female adolescents, a higher sUA level (turning point, 3.9 mg/dL) may have an adverse effect on bone health.

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Association between serum uric acid and bone health in adolescents

Cited by 15 publications

References 39 publications

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

Age and Gender-Specific Reference Intervals for Uric Acid Level in Children Aged 5–14 Years in Southeast Zhejiang Province of China: Hyperuricemia in Children May Need Redefinition

Association of Serum Uric Acid Status With Bone Mineral Density in Adolescents Aged 12–19 Years

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