Association Between Vitamin D and Uric Acid in Adults: A Systematic
                    Review and Meta-Analysis

Isnuwardana, Ronny; Thadanipon, Kunlawat; Ingsathit, Atiporn; Thakkinstian, Ammarin

doi:10.1055/a-1240-5850

Cited by 24 publications

(15 citation statements)

References 74 publications

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“…The analysis of the National Health and Nutrition Examination Survey (NHANES) 2007–2014, that included 18.596 individuals, documented that the lowest quartile of vitamin D levels had significative higher risk of hyperuricemia in comparison with the highest quartile ( 74 ). These data were consistent with studies on different cohorts and meta-analyses ( 75 – 77 ).…”

Section: Deficit Of Vitamin D and Cv Risk Factorssupporting

confidence: 92%

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances

Trimarco

Manzi

Mancusi

et al. 2022

Front. Cardiovasc. Med.

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Vitamin D is a steroid hormone that plays a key role in the regulation of body homeostasis, including cardiovascular function. Although the chronic deficiency of vitamin D is associated with cardiovascular risk factors, as well as with an adverse prognosis, randomized controlled trials have failed in demonstrating that dietary vitamin D supplementation could ameliorate the prognosis of patients with cardiovascular diseases, and suggested that vitamin D deficiency is the expression of the effects of other determinants of cardiovascular risk. Thus, the supplementation of vitamin D is not sufficient to improve the cardiovascular risk profile and prognosis. Insulin resistance is a complex phenomenon that plays a key role in the pathogenesis of conventional cardiovascular risk factors. Interestingly, defects of vitamin D and insulin resistance have a superimposable epidemiological distribution. According to the common view, Insulin resistance is considered the direct or indirect consequence of vitamin D deficiency. However, it is also reasonable to speculate that the deficit or the impaired action of vitamin D, in some circumstances, could be the result of the same pathogenic mechanisms responsible of insulin resistance development. In this case, vitamin D deficiency could be considered an epiphenomenon of insulin resistance. Insulin resistance is a reversible condition, being possibly ameliorated by physical activity and hypocaloric diets. Notably, both physical exercise and energy-restricted dietary regimens are associated with an increase of vitamin D levels. These findings indicate that improving insulin resistance condition is a necessary step to ameliorate vitamin D supplementation-based strategies in cardiovascular prevention.

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Section: Deficit Of Vitamin D and Cv Risk Factorssupporting

confidence: 92%

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances

Trimarco

Manzi

Mancusi

et al. 2022

Front. Cardiovasc. Med.

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“…First, some of the important biochemical measurements, such as parathyroid hormone and serum uric acid levels, were not available due to lack of data. Parathyroid hormone levels are related to the clearance of uric acid [ 39 ], and high levels of uric acid are known to be associated with the deficiency of vitamin D, an important factor for bone health [ 40 , 41 ]. Furthermore, it was difficult to determine whether the increase in uric acid levels in the urine of patients with osteoporosis was caused by excessive uric acid excretion due to an overall increase in uric acid, or by an abnormal loss via urine despite a normal amount of circulating uric acid in serum.…”

Section: Discussionmentioning

confidence: 99%

Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort

Park

Kim

et al. 2021

JCM

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Osteoporosis is a major public health concern, especially in women. This study aims to identify early biomarkers from biochemical measurements of serum and urine for recognizing the development of osteoporosis and osteopenia in premenopausal and postmenopausal women. From the Korean Genome and Epidemiology Study (KoGES) cohort, longitudinal study participants with normal bone density were enrolled and assessed for the association of baseline clinical and biochemical factors with osteoporosis development over 4 years. In addition, a cross-sectional study between normal bone density and osteopenia/osteoporosis was conducted to validate the risk factors found in the longitudinal cohort. Of the 5272 female participants in the KoGES cohort, 813 women (501 premenopausal and 312 menopausal) who had normal bone density at baseline were included in the longitudinal study. During the 4 years of follow-up, 64 patients developed osteoporosis and 354 developed osteopenia. In a multivariate logistic regression analysis, serum calcium and urine uric acid levels were significantly associated with elevated osteoporosis risk in premenopausal and postmenopausal women, respectively (risk of osteoporosis by serum calcium levels in premenopausal women: 4.03 (1.09–14.93), p = 0.037; risk of osteoporosis by urine uric acid levels in postmenopausal women: 24.08 (1.79–323.69), p = 0.016). For the cross-sectional study, serum and urine parameters were compared between women with osteopenia or osteoporosis at baseline and those with normal bone density. Urine uric acid levels were found to be significantly higher in both premenopausal and postmenopausal women with bone loss than in women with normal bone density (p < 0.001 and p = 0.004, respectively). Uric acid level in urine may be an early marker for the development of osteoporosis in women, especially after menopause.

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“…Be to, esant vit. D stokai, 1,5 karto išauga hiperurikemijos tikimybė, nes šlapimo rūgšties pertekliaus sąlygomis blokuojama 1-α hidroksilazė, verčianti 25(OH)D į kalcitriolį [26]. Yra žinoma, jog organizme vykstant uždegiminiams procesams, vit.…”

Section: Diskusijaunclassified

Besimptomė Hiperurikemija Ir Nutukimas. Klinikinis Atvejis

Marčiulynaitė¹,

Šnipaitienė²,

Jankauskaitė³

2022

Health Sciences

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Hiperurikemija, arba šlapimo rūgšties perteklius kraujyje, yra sąlyginai dažnas laboratorinių tyrimų radinys ne tik suaugusiųjų, bet ir vaikų amžiuje, ypač nutukusiems asmenims, esant padidėjusiam arteriniam kraujospūdžiui, metaboliniam sindromui ar lėtinei inkstų ligai. 90 proc. hiperurikemijos atvejų lemia sutrikęs šlapimo rūgšties šalinimas per inkstus, kitą dalį sudaro padidėjusi šlapimo rūgšties gamyba, skylant purinams. Perteklinė serumo uratų koncentracija ilgainiui gali sukelti inkstų akmenligę ar podagrą, todėl svarbu atrinkti pacientus, kuriems reikalingas šlapimo rūgšties kiekį mažinantis gydymas. Besimptomės hiperurikemijos korekcija pradedama nuo dietos su sumažintu purinų kiekiu maiste ir rizikos veiksnių šalinimo (pvz., antsvorio mažinimo). Nors apibrėžto sutarimo dėl gydymo reikalaujančios ribinės šlapimo rūgšties koncentracijos nėra, medikamentai, tokie kaip alopurinolis, besimptomės hiperurikemijos atveju skiriami tik esant itin ženkliam serumo uratų kiekio padidėjimui. Šiame straipsnyje aptarsime besimptomės hiperurikemijos, nustatytos nutukusiai paauglei, klinikinį atvejį, pasireiškusį kartu su keletą metų stebimu uždegiminių rodiklių padidėjimu nesant lėtinės infekcijos požymių, skilveline ekstrasistolija ir vitamino D stoka, bei pateiksime besimptomės hiperurikemijos vaikų amžiuje literatūros analizę.

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Association Between Vitamin D and Uric Acid in Adults: A Systematic Review and Meta-Analysis

Cited by 24 publications

References 74 publications

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances

Insulin Resistance and Vitamin D Deficiency: A Link Beyond the Appearances

Urine and Serum Electrolytes and Biochemical Values Associated with Osteoporosis in Premenopausal and Postmenopausal Women: A Longitudinal and Cross-Sectional Study Using Korean Genome and Epidemiology Study (KoGES) Cohort

Besimptomė Hiperurikemija Ir Nutukimas. Klinikinis Atvejis

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