Efeito da bomba de infusão de soluções sobre o grau de hemólise em concentrados de hemácias

Carvalho, Eunice B.; Borges, Émerson L.; Carlos, Luciana M. B.; Silva, Marcos Antônio M.; Magalhães, S.M.M.; Gomes, Francisca Vânia Barreto Aguiar Ferreira; Carvalho, Márcio J. C.; Quixadá, Acy Telles de Souza; Pitombeira, Maria H. S.

doi:10.1590/s1516-84842007000200013

Cited by 20 publications

(21 citation statements)

References 9 publications

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“…Red blood cell lyses can cause an elevation in plasma hemoglobin leading to harmful effects in the kidneys (nephrotoxicity), and in the cardiovascular system (vasomotor effect) (Carvalho et al, 2007). Therefore, negative hemolytic activity is a good indicator because it confirms no toxicity to erythrocyte membrane.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)

Kalegari

Miguel

Dias

et al. 2011

Braz. J. Pharm. Sci.

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Most active plants are toxic at high doses and it is therefore important to investigate the preliminary toxicity of plant extracts. The Rourea induta species is a potential drug with no phytochemical or biological studies registered in the literature. Thus, a phytochemical study and a toxicity analysis of the ethanolic extract obtained from the leaves of Rourea induta Planch., Connaraceae, was run. A long chain hydrocarbon, n-tetracosane, and four flavonoids were identified: quercetin, and three glycosylated derivates, quercetin-3-O-α-arabinofuranoside, quercetin-3-O-β-xyloside and quercetin-3-O-β-galactoside. This is the first time these have been isolated in this species. The structures were elucidated by 13 C NMR, 1 H NMR, UV and IR spectroscopy. The toxicity evaluation of extracts was performed by the brine shrimp method and determination of hemolytic activity. The samples demonstrated no toxic potential by the analyzed methods. A maioria das plantas ativas é tóxica em doses elevadas, portanto, é importante a investigação da toxicidade preliminar dos extratos das plantas. A espécie Rourea induta é uma droga potencial que não apresenta estudo fitoquímico ou biológico descrito na literatura. Assim, um estudo fitoquímico e análises toxicológicas foram realizados com o extrato etanólico obtido das folhas de Rourea induta Planch., Connaraceae. Foram obtidos um hidrocarboneto de cadeia longa, n-tetracosano, e quatro flavonóides, quercetina e três derivados glicosilados, quercetina-3-O-α-arabinofuranosideo, quercetina-3-O-β-xilosideo e quercetina-3-O-β-galactosideo. Esta é a primeira vez que estes compostos são isolados nesta espécie. As estruturas foram elucidadas por espectroscopia de RMN-13 C, RMN-1 H, ultravioleta e infravermelho. A avaliação da toxicidade dos extratos foi analisada pelo método da Artemia salina e atividade hemolítica. Nenhuma das amostras testadas apresentou um potencial tóxico pelos métodos analisados.Unitermos: Rourea induta/fitoquímica. Connaraceae/fitoquímica. Flavonóides. N-tetracosano. Extrato de plantas/toxicidade.

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Section: Resultsmentioning

confidence: 99%

Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)

Kalegari

Miguel

Dias

et al. 2011

Braz. J. Pharm. Sci.

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“…The solutions commonly used CPDA-1 that conserves the CH for 35 days and the additives solutions that preserve erythrocytes for 42 days. Publications suggest that the preservative solutions saline-adenine-glucosemannitol (SAG-M) reduces the final hematocrit for blood components, however further research should focus on the differences between preservative solutions, hematocrit and blood components such as red blood cells leukoreduced, washed and radiated 19 , 28 .…”

Section: Discussionmentioning

confidence: 99%

Infusion pumps and red blood cell damage in transfusion therapy: an integrative revision of the academic literature

Wilson

Peterlini

2016

Rev. Latino-Am. Enfermagem

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Objectives: to obtain information from scientific literature concerning infusion pumps used in administering erythrocyte (red blood cells) and to evaluate the implications in the practical use of this equipment by nurses when conducting transfusions.Method: an integrative revision of the following scientific databases: Pubmed/Medline, Scopus, the Virtual Library for Health, SciELO, Web of Science and Cochrane. The following descriptors were used: "infusion pumps", "blood transfusion", "transfused erythrocyte" and "hemolyis". There were no restrictions on the scope of the initial data and it was finalized in December 2014. 17 articles were identified in accordance with the inclusion and exclusion criteria. Results: all of the publications included in the studies were experimental in vitro and covered the use of infusion pumps in transfusion therapy. A summary of the data was presented in a synoptic chart and an analysis of it generated the following categories: cellular damage and the infusion mechanism. Conclusion: infusion pumps can be harmful to erythrocytes based on the infusion mechanism that is used, as the linear peristaltic pump is more likely to cause hemolysis. Cellular damage is related to the plasmatic liberation of markers that largely dominate free hemoglobin and potassium. We reiterate the need for further research and technological investments to guide the development of protocols that promote safe practices and that can contribute to future clinical studies.

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“…Durante os processos hemoterápicos pode ocorrer hemólise extracorpórea. Essa ocorre, principalmente, durante a estocagem do concentrado de hemácias ou por trauma mecânico durante a transfusão (4) . A lesão da membrana das hemácias causa a liberação de hemoglobina no plasma, além disso, uma alta carga de potássio livre é liberada.…”

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Hemólise De Eritrócitos Em Dispositivos De Infusão Intravenosa: Revisão Integrativa Da Literatura

et al. 2015

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RESUMO:Hemólise extracorpórea pode ser identificada durante processos hemoterápicos. O enfermeiro é um dos profissionais responsáveis pela administração de hemocomponentes e controle de possíveis riscos, portanto deve apropriar-se de conhecimentos que respaldem a prática clínica. O objetivo foi identificar na literatura aspectos relacionados à hemólise em concentrados de hemácias decorrentes de administração de sangue por dispositivos de infusão intravenosa. Realizou-se Revisão Integrativa da Literatura. Incluídos artigos na língua inglesa, espanhola e portuguesa, sem delimitação da data, indexados em quatro bases de dados. Foram selecionadas 12 (100,0%) produções científicas, sendo que em sete (58,3%) foram analisadas bombas de infusão, em duas (16,7%) a manipulação de eritrócitos, em duas (16,7%) a hemólise com combinações de dispositivos e em uma (8,3%) cateter intravenoso. Os resultados de quatro (33,3%) destes estudos evidenciaram ocorrência de hemólise. Os estudos apontaram que pode ocorrer hemólise durante a passagem do componente por bombas de infusão e cateteres. DESCRITORES: HEMOLYSIS OF ERYTHROCYTES IN INTRAVE-NOUS INFUSION DEVICES: AN INTEGRATIVE REVIEW OF THE LITERATUREABSTRACT: Extracorporeal hemolysis may be identified during hemotherapy. The nurse is one of the professionals responsible for the administration of blood components and the control of possible risks, and must therefore acquire the knowledge which supports clinical practice. The objective was to identify, in the literature, aspects related to hemolysis in concentrates of red blood cells resulting from the administration of blood through intravenous infusion devices. An Integrative Review of the Literature was undertaken, including articles in the English, Spanish and Portuguese languages, without limitation of data, indexed in four databases. A total of 12 (100.0%) scientific productions were selected, of which seven (58.3%) analyzed infusion pumps, two (16.7%) the handling of erythrocytes, two (16.7%) hemolysis with combinations of devices, and one (8.3%), the intravenous catheter. The results of four (33.3%) of these studies evidenced the occurrence of hemolysis. The studies indicated that hemolysis can occur during the passage of the component through infusion pumps and catheters. HEMOLISIS DE ERITROCITOS EN DISPOSITIVOS DE INFUSIÓN: REVISIÓN INTEGRATIVA DE LA LITERATURA RESUMEN:Hemolisis extracorpórea puede ser identificada durante procesos hemoterápicos. El enfermero es uno de los profesionales responsables por la administración de hemocomponentes y control de posibles riesgos, por lo tanto debe apropriarse de conocimientos para garantizar la práctica clínica. El objetivo fue identificar en la literatura aspectos de la hemolisis en concentrados de hematíes decurrentes de administración de sangre por dispositivos de infusión intravenosa. Fue realizada revisión integrativa de la literatura. Se utilizaron artículos en lengua inglesa, española y portuguesa, sin delimitación de fecha, indexados en cuatro bases de datos. Fueron selec...

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Efeito da bomba de infusão de soluções sobre o grau de hemólise em concentrados de hemácias

Abstract: Artigo / ArticleEfeito da bomba de infusão de soluções sobre o grau de hemólise em concentrados de hemácias Effect of the infusion pumps of solutions on the degree of hemolysis

Cited by 20 publications

References 9 publications

Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)

Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)

Infusion pumps and red blood cell damage in transfusion therapy: an integrative revision of the academic literature

Hemólise De Eritrócitos Em Dispositivos De Infusão Intravenosa: Revisão Integrativa Da Literatura

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