2011
DOI: 10.1590/s1984-82502011000300023
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Phytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae)

Abstract: Most active plants are toxic at high doses and it is therefore important to investigate the preliminary toxicity of plant extracts. The Rourea induta species is a potential drug with no phytochemical or biological studies registered in the literature. Thus, a phytochemical study and a toxicity analysis of the ethanolic extract obtained from the leaves of Rourea induta Planch., Connaraceae, was run. A long chain hydrocarbon, n-tetracosane, and four flavonoids were identified: quercetin, and three glycosylated d… Show more

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Cited by 44 publications
(29 citation statements)
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“…A quantidade de hemoglobina livre no plasma depende da capacidade e da velocidade de remoção do pigmento pelo organismo de cada indivíduo, sendo fisiológica a quantidade de 6 mg%. Quando este valor supera 100 mg% a hemoglobina passa a ser filtrada pelos rins e quando excessivamente alto (superiores a 3.000 mg%), pode promover lesão renal (Carvalho et al, 2007;Kalegari et al, 2011 …”
Section: Resultado E Discussãounclassified
See 1 more Smart Citation
“…A quantidade de hemoglobina livre no plasma depende da capacidade e da velocidade de remoção do pigmento pelo organismo de cada indivíduo, sendo fisiológica a quantidade de 6 mg%. Quando este valor supera 100 mg% a hemoglobina passa a ser filtrada pelos rins e quando excessivamente alto (superiores a 3.000 mg%), pode promover lesão renal (Carvalho et al, 2007;Kalegari et al, 2011 …”
Section: Resultado E Discussãounclassified
“…Após este período verificou-se a formação de halo de hemólise. Os halos foram então medidos e os resultados expressos como média dos halos encontrados em duplicata (Kalegari et al, 2011).…”
Section: Atividade Hemolíticaunclassified
“…A maioria das plantas é tóxica em doses elevadas, portanto é necessária a investigação da toxicidade dos extratos (KALEGARI et al, 2011). As reações adversas que as plantas podem causar possivelmente são decorrentes de seus próprios componentes, pela presença de contaminantes ou, até mesmo, pelas preparações caseiras duvidosas (ALMEIDA et al, 2010).…”
Section: Discussionunclassified
“…Aqueous extract from leavesantinociceptive actions [59] leaf ethanolic extract -in vitro antioxidant activity associated to in vivo hepatoprotective potential [131,132,133] treatment of rheumatisms and Chagas disease [134] Solanum kwebense (Solanaceae) --cerebellar cortical substance degeneration, involving selectively Purkinje neurons [65] abdominal pain, inflammation and rheumatism [32] Xeromohis nilotica (Rubiaceae) aqueous extract from root bark -antinociceptive effect [61] aqueous extract from root bark-short antiinflammatory quality [61]; rootbark extracts -sedative activities [135,136]; antischistosomal [137], molluscidal [138] activities pain, fever, epilepsy and mental disorder [139,140] Consequently, if we take into consideration that synergism between cannabinoids and opioids modulates performance in the fight against pain by targeting multiple pain mechanisms and also the aforementioned antipsychotic and antinociceptive proprieties of cannabidiol and the involvement of opioid mechanisms in pain and schizophrenia, we might be looking at the beginning of a new era in the treatment of pain, but also in the battle against schizophrenia, this complex severe mental illness with modified perception of pain.…”
Section: Phyllanthus Fraternus (Euphorbiaceae)mentioning
confidence: 99%