Objectives: to obtain information from scientific literature concerning infusion pumps used
in administering erythrocyte (red blood cells) and to evaluate the implications in
the practical use of this equipment by nurses when conducting transfusions.Method: an integrative revision of the following scientific databases: Pubmed/Medline,
Scopus, the Virtual Library for Health, SciELO, Web of Science and Cochrane. The
following descriptors were used: "infusion pumps", "blood transfusion",
"transfused erythrocyte" and "hemolyis". There were no restrictions on the scope
of the initial data and it was finalized in December 2014. 17 articles were
identified in accordance with the inclusion and exclusion criteria. Results: all of the publications included in the studies were experimental in vitro and
covered the use of infusion pumps in transfusion therapy. A summary of the data
was presented in a synoptic chart and an analysis of it generated the following
categories: cellular damage and the infusion mechanism. Conclusion: infusion pumps can be harmful to erythrocytes based on the infusion mechanism
that is used, as the linear peristaltic pump is more likely to cause hemolysis.
Cellular damage is related to the plasmatic liberation of markers that largely
dominate free hemoglobin and potassium. We reiterate the need for further research
and technological investments to guide the development of protocols that promote
safe practices and that can contribute to future clinical studies.
Objective:To evaluate the hemolysis biomarkers of packed red blood cells transfused by
two different linear peristaltic infusion pumps at two infusion rates. Method:An experimental and randomized study was designed simulating the clinical
practice of transfusion. Two linear peristaltic infusion pumps from
different manufactures were studied in triplicate at 100 mL/h and 300mL/h
infusion rates. The chosen hemolysis biomarkers were total hemoglobin, free
hemoglobin, hematocrit, potassium and degree of hemolysis. They were
analyzed before and after each infusion. Results:Potassium showed statistically significant variations in all scenarios of the
experiment (P<0.010). In a separated analysis, potassium increased mainly
at 300mL/h rate (P=0.021) and free hemoglobin had significant variation when
comparing infusion pumps from different manufacturers (P=0.026). Although
hematocrit, total hemoglobin and degree of hemolysis had increased after
infusion, no statistically significance variations were identified. Conclusions:Hemolysis risk induced by a linear peristaltic infusion pump was identified
by an increase in free hemoglobin and potassium markers. As the potassium
biomarker is often increased in aged packed red blood cells, we do not
recommend using them in this scenario. Additional studies should be
performed about other markers and using larger samples in order to reinforce
the transfusion practice in nursing.
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