Excess deoxycorticosterone secretion from adrenocortical carcinoma.

Powell-Jackson, J. D.; Călin, A; Fraser, Russell; Grahame, R.; Mason, P A; Missen, G. A. K.; Powell-Jackson, P R; Wilson, Ana Maria Miranda Martins

doi:10.1136/bmj.2.5909.32

Cited by 39 publications

(15 citation statements)

References 10 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The normal plasma aldosterone level in the preoperative period in this case is in line with the findings of almost normal preoperative plasma aldosterone levels observed in DOC (Powell-Jackson et al, 1974;Kondo et al, 1976;Davies et al, 1980) or B (Fraser et al, 1968;Mills et al, 1980) producing adrenal tumor reported previously. We could not examine the aldosterone content and/or histological view of the adjacent adrenal tissue, but the basal aldosterone release from it in this case was much less than that in control adrenal tissue, although it was far more than that in tumor tissue.…”

Section: Discussionsupporting

confidence: 91%

“…Adrenocortical tumors producing DOC (Powell-Jackson et al, 1974;Davies et al, 1980;Kondo et al, 1976) or B (Fraser et al, 1968;Mills et al, 1980), either malignant (Powell-Jackson et al, 1974;Davies et al, 1980;Fraser et al, 1968) or benign (Kondo et al, 1976;Mills et al, 1980), have been documented as hypermineralocorticoidism other than hyperaldosteronism. All these patients had severe hypertension and hypopotassemia.…”

Section: Discussionmentioning

confidence: 99%

“…cinoma with hypersecretion of 11-deoxycorticosterone (DOC) (Powell-Jackson et al, 1974;Devies et al, 1980) or corticosterone (B) (Fraser et al, 1968) and of adenoma excessively producing DOC (Kondo et al, 1976) or B (Mills et al, 1980) were documented.…”

mentioning

confidence: 99%

See 2 more Smart Citations

An Adrenocortical Tumor Secreting Weak Mineralocorticoids

et al. 1987

View full text Add to dashboard Cite

An adrenocortical carcinoma (15.5g) secreting excessive amounts of steroids with weak mineralocorticoid activity in a25-year-old woman was studied with particular reference to its in vivo and in vitro secretions of steroids. Severe hypertension, occasional low serum potassium and suppressed PRA were the major clinical findings, and were improved with removal of the tumor. In the preoperative stage, plasma levels of 11-deoxycorticosterone, 18-hydroxy-11-deoxycorticosterone, corticosterone and 18-hydroxycorticosterone were all increased. However, the plasma level of aldosterone was repeatedly normal. Although plasma levels of pregnenolone, 17-hydroxypregnenolone, progesterone and 17-hydroxyprogesterone were very high, those of other late step steroids, i.e. 11-deoxycortisol, cortisol, dehydroepiandrosterone, androstenedione and testosterone were almost normal. From these findings, a major etiological role of weak mineralocorticoids such as 11-deoxycorticosterone, 18-hydroxycorticosterone and corticosterone in her hypertension was suggested.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

An Adrenocortical Tumor Secreting Weak Mineralocorticoids

et al. 1987

View full text Add to dashboard Cite

show abstract

“…However, at concentrations of 100 ng/dl or greater, such as might be anticipated in patients with 17-hydroxylase deficiency (2,4) or certain forms of Cushing's syndrome (43,44), deoxycorticosterone should produce marked sodium-retaining activity. Consistent with this, plasma deoxycorticosterone concentrations in the 100-500 ng/dl range are occasionally observed in patients with adrenal carcinoma who show hypertension and hypokalemia (41,43). A further indication that our procedure for measuring competitive activity can detect deoxycorticosterone when it is present in sufficient concentration to exhibit marked clinical effects is our finding (unpublished) that marked elevations of competitor activity are found in plasma after administration of large dosages of deoxycorticosterone (20 mg/day) to patients.…”

Section: Discussionsupporting

confidence: 66%

“…Of particular interest in this regard is deoxycorticosterone. In normals, the plasma deoxycorticosterone concentration is around 7-10 ng/dl or 0.2-0.3 nM (17,41,42). Concentrations of this steroid in the 20-100 ng/dl range have been reported in low-renin essential hypertension (17).…”

Section: Discussionmentioning

confidence: 99%

Aldosterone receptors and the evaluation of plasma mineralocorticoid activity in normal and hypertensive states.

Baxter¹,

Schambelan²,

Matulich³

et al. 1976

J. Clin. Invest.

View full text Add to dashboard Cite

A B S T R A C T Aldosterone receptors from rat kidney slices were utilized in a competitive binding technique to analyze the contribution of various steroids to plasma "mineralocorticoid" activity and to assess their possible role in hypertension. To consider simultaneously the plasma binding, steroids were incubated with slices in undiluted plasma; competitor activities for [3H]aldosterone binding were aldosterone, 100%; deoxycorticosterone, 16.2%; cortisol, 0.4%; and 18-hydroxy-deoxycorticosterone and 18-hydroxy-corticosterone, 0.1%. These steroids were more active in buffer than plasma, suggesting that they bind to plasma and that this reduces their receptor binding. Analysis of the competition data suggests that at normal plasma concentrations, aldosterone occupies the receptors to a major extent, cortisol occupies some of the receptors, and deoxycorticosterone and 18-hydroxydeoxycorticosterone contribute little to receptor occupancy. Two steroids implicated in low-renin essential hypertension, 16i#-hydroxy-dehydroepiandrosterone and 16-oxoandrostenediol, did not have significant competitor activity.Competitor activity in plasmas from normal subjects taken at 12 noon (upright) was greater than that in those taken at 8 a.m. (supine). Since the 12 noon samThis work has been published in abstract form: 1975.

show abstract

Adrenocortical Carcinoma

Kannan¹

1988

The Adrenal Gland

View full text Add to dashboard Cite

Excess deoxycorticosterone secretion from adrenocortical carcinoma.

Cited by 39 publications

References 10 publications

An Adrenocortical Tumor Secreting Weak Mineralocorticoids

An Adrenocortical Tumor Secreting Weak Mineralocorticoids

Aldosterone receptors and the evaluation of plasma mineralocorticoid activity in normal and hypertensive states.

Adrenocortical Carcinoma

Contact Info

Product

Resources

About