Sintomas depressivos e ansiosos em mulheres com hipotireoidismo

Andrade, Nelson Elias; Pires, Maria Lúcia Elias; Thuler, Luiz Cláudio Santos

doi:10.1590/s0100-72032010000700003

Cited by 20 publications

(8 citation statements)

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“…Portanto, há uma prevalência razoável de sobreposição entre as duas condições (Panicker et al 2009). No estudo de Andrade Júnior et al (2010), foi demonstrada que a presença concomitante de ansiedade e depressão foi cinco vezes maior entre os casos do que entre os controles. A ocorrência de sintomas ansiosos foi cerca de três vezes maior entre os casos (40%) em relação aos controles (14%), enquanto a prevalência de sintomas depressivos mostrou-se 75% superior entre casos (28%) quando comparada aos controles (16%).…”

Section: Resultsunclassified

Hipotireoidismo e sua associação com transtornos depressivos: uma revisão de literatura

Neto

Figueiredo

Oliveira

2021

RSD

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Introdução: A função tireoidiana está intimamente associada às funções neuropsicológicas, incluindo o estado mental e as funções cognitivas. O hipotireoidismo subclínico (HSC) é definido como uma condição com níveis elevados de hormônio estimulador da tireoide (TSH) e níveis normais de tiroxina livre (T4). Objetivo: evidenciar a relação entre hipotireoidismo e transtorno depressivo. Metodologia: trata-se de uma pesquisa descritiva do tipo revisão integrativa. A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, EBSCO Information Services, no mês de agosto de 2021. Resultados: Ainda que não seja claro o papel desempenhado pelos hormônios tireoidianos na fisiopatologia dos transtornos mentais, tem sido sugerido que pequenas mudanças nos níveis de hormônio da tireoide, mesmo dentro da faixa normal, podem estar relacionadas à alteração da função cerebral na depressão. Atualmente, existem 2 hipóteses explicativas: o déficit de serotonina e o déficit de noradrenalina no sistema nervoso central provocados pelos distúrbios hormonais. É importante ressaltar que a via tireoidiana-psíquica é bidirecional, portanto, tanto alterações tireoidianas podem provocar sintomas depressivos ou exacerbar uma patologia psiquiátrica prévia, quanto a depressão pode promover distúrbios tireoidianos, sendo este segundo caso menos frequente. Conclusão: O papel da função tireoidiana nas doenças depressivas é pouco claro. Embora existam algumas evidências de que discretas alterações tireoidianas predisponham a casos de depressão, as anormalidades específicas envolvendo a tireoide e os quadros depressivos permanecem pouco conhecidas. No entanto, existe um vínculo de causalidade.

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Section: Resultsunclassified

Hipotireoidismo e sua associação com transtornos depressivos: uma revisão de literatura

Neto

Figueiredo

Oliveira

2021

RSD

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“…Распространенность психических расстройств при заболеваниях щитовидной железы (ЩЖ) оценивается в широком диапазоне -от 5,1 до 63% [1][2][3][4][5][6][7][8][9], что может быть объяснено использованием различных методик их оценки и неоднородными выборками пациентов. По данным наиболее методологически однородных работ, частота психических расстройств при заболеваниях ЩЖ составляет 28-45% [2,3,9], что, по всей вероятности, в большей степени соответствует клинической реальности, однако требует проведения дальнейших исследований.…”

Section: эпидемиологияunclassified

Mental Disorders in Hypo- and Hyperthyroidism: History of the Problem and Some Hypotheses of Potential Psychosomatic Research

et al. 2023

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Background: the problem of diseases of the thyroid gland (TG) remains relevant. The clinical picture and prevalence of diseases, as a rule, is analysed depending on the nosological form and severity of endocrinopathy. However, the estimated cases of morbidity syndrome on the basis of modern systemic diseases, the alleged reasonable appointment of endocrinopathies with places — the outcome of the syndromic/functional situation of thyroid disease, are divided into suspected either hypo- or hyperthyroidism.Objective: analysis of publications on the birth of diseases in hypo- and hyperthyroidism with the earliest possible search depth (publications since 1835), aimed at identifying current problems and relevant characteristics.Material and method: according to the key features “hypothyroidism”, “hyperthyroidism”, “mental disorders”, “depression”, “anxiety”, “psychosis”, literary sources in the MEDLINE/PubMed Scopus, Google Scientist databases were signiﬁcant and studied.Conclusion: as a result of the analysis of the literature, it was revealed that the number of studies of the prevalence of diseases among the population in thyroid diseases compared to other somatic diseases is small, and many questions about the relationship between mantal diseases and diseases of thyroid glands that are currently unresolved. The thyroid gland is limited to affective and anxiety symptoms/syndromes, and genetic belonging to certain categories (nosogenic, somatogenic, endoform) is not qualiﬁed. At the same time, a number of signiﬁcant aspects of the problem are discussed: “common symptoms” of mental afﬁliation and thyroidopathy, duplicating/ imitating each other; psychopathological prodromes and “masks” of thyroid diseases; stress induction, such as in Graves’ disease; psychopathological disorders, such as non-psychotic and psychotic registries, with analysis of the characteristics of limb features for the use of the thyroid gland.

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“…Hypothyroidism has been associated with different neuropsychiatric disorders (mania, acute psychosis, psychiatric disturbances due to iatrogenic hypothyroidism, cognitive disorders, and, primarily, mood changes) [4,5,6,7,8,9,10,11]. A higher prevalence of depressive symptoms and worse scores on depression scales have been found in patients with clinical and subclinical hypothyroidism [11,12,13,14], and a higher prevalence of hypothyroidism has been found in patients with major depressive disorders (MDD) [15,16,17,18]. Regarding anxiety, its prevalence in hypothyroid patients can reach 63%–65% [7,11,13,19].…”

Section: Introductionmentioning

confidence: 99%

“…A higher prevalence of depressive symptoms and worse scores on depression scales have been found in patients with clinical and subclinical hypothyroidism [11,12,13,14], and a higher prevalence of hypothyroidism has been found in patients with major depressive disorders (MDD) [15,16,17,18]. Regarding anxiety, its prevalence in hypothyroid patients can reach 63%–65% [7,11,13,19]. Different authors also found a relationship between scores on anxiety scales and hypothyroidism [4,20,21].…”

Section: Introductionmentioning

confidence: 99%

Mood Disorders in Levothyroxine-Treated Hypothyroid Women

Romero-Gómez

Guerrero-Alonso

Carmona‐Torres

et al. 2019

IJERPH

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Background: Hypothyroidism has several symptoms (weight gain, arrhythmias, mood changes, etc.). The aims of this study were (1) to assess the prevalence of anxiety and depression in levothyroxine-treated hypothyroid women and in women without hypothyroidism; (2) to identify variables associated with anxiety and depression. Methods: A case-control study was performed with 393 women. Case-group: 153 levothyroxine-treated hypothyroid women. Control-group: 240 women without hypothyroidism. Convenience sampling. Instrument: The Hamilton Hospital Anxiety and Depression Scale (HADS), and a sociodemographic questionnaire. Results: The prevalence of anxiety in levothyroxine-treated hypothyroid women was higher than in women without hypothyroidism (29.4% vs. 16.7%, χ2p < 0.001). The prevalence of depression in the case group was higher than in the control group (13.1% vs. 4.6%, χ2 p < 0.001). Levothyroxine-treated hypothyroid women were more likely to have anxiety (OR = 2.08, CI: 1.28–3.38) and depression (OR = 3.13, IC = 1.45–6.45). Conclusion: In spite of receiving treatment with levothyroxine, women with hypothyroidism are more likely to have depression and anxiety. Health professionals need to assess the mood of women with hypothyroidism. Although levothyroxine is a good treatment for the symptoms of hypothyroidism, it may not be enough to prevent development or persistence of depression and anxiety by itself.

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Sintomas depressivos e ansiosos em mulheres com hipotireoidismo

Cited by 20 publications

References 0 publications

Hipotireoidismo e sua associação com transtornos depressivos: uma revisão de literatura

Hipotireoidismo e sua associação com transtornos depressivos: uma revisão de literatura

Mental Disorders in Hypo- and Hyperthyroidism: History of the Problem and Some Hypotheses of Potential Psychosomatic Research

Mood Disorders in Levothyroxine-Treated Hypothyroid Women

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