Riscos e benefícios do uso dos inibidores seletivos da recaptação de serotonina para a depressão durante a gravidez e a lactação

Nomura, Marcelo Luís; Silva, João Luís Carvalho Pinto e

doi:10.1590/s0100-72032007000700001

Cited by 5 publications

(4 citation statements)

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“…This disease affects 10% of women worldwide and the use of antidepressants drugs during pregnancy is 1 in every 10 women (Payne & Meltzer-Brody 2007). The scientific literature so far point out that the syndromes caused by the use of SSRIs in newborns are residual effects of the drug or withdrawal symptoms caused by the interruption of its passive exposure, characterized by changes in crying, tachypnea, mild respiratory failure, gastrointestinal disorders and cyanosis (Nomura & Silva 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Early-life exposure to fluoxetine can cause alterations in the amount of serotonin available in the synaptic clefts, which affects the processes of neurogenesis, neural differentiation and synaptogenesis (Da Silva et al 2010;Pinheiro et al 2019). Furthermore, fluoxetine can penetrate the placental barrier during pregnancy, potentially causing withdrawal syndrome in the newborn due to the interruption of this passive exposition (Nomura & Silva 2007;Nunes et al 2021).…”

Section: Introductionmentioning

confidence: 99%

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Fluoxetine alters rat's milk properties causing impact on offspring's development

Zaccarelli-Magalhães

et al. 2023

Preprint

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Fluoxetine is an antidepressant used to treat several conditions including postpartum depression. This disease causes cognitive, emotional, behavioral and physical changes, negatively affecting the mother, child and family life. However, fluoxetine is excreted in breast milk, causing short and long-term effects on children who were exposed to the drug during lactation, so studies that seek to uncover these consequences are needed. Thus, the aim of this study was to evaluate the effects of fluoxetine on rat milk’s properties and on the physical and neurobehavioral development of the offspring. Lactating rats were divided into 4 groups: control group and three experimental groups, which were treated with different doses of fluoxetine (1, 10 and 20 mg/kg) during the lactation. Dams body weight and milk properties were measured, as well as offspring’s physical and neurobehavioral development. Results showed that the use of fluoxetine during lactation decreased dam’s body weight and alters milk’s properties, leading to implications on the offspring growth until adulthood. Therefore, the use of fluoxetine during lactation needs to be cautiously evaluated, with the benefits to the mothers and the associated risk to the offspring carefully balance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluoxetine alters rat's milk properties causing impact on offspring's development

Zaccarelli-Magalhães

et al. 2023

Preprint

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“…Of the interviewees, four (50%) were using the aforementioned medication, with three (37.5%) saying they adapted and felt positive effects with the drug. Near to fluoxetine hydrochloride, paroxetine hydrochloride, venlafaxine hydrochloride, fluvoxamine maleate and citalopram hydrobromide, sertraline hydrochloride It is one of the most commonly prescribed medications (NOMURA, SILVA;2007).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Itineraries of Pregnant and Puerperous Women With Anxious and Depressive Symptoms, Up to One Year After Birth, in the Municipality of Chapecó – Sc

Rossetto,

Noal,

Silva

et al. 2023

JHS

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The present work aims to identify the characteristics of women with anxious and/or depressive symptoms during pregnancy and postpartum, within one year after birth, and their therapeutic itineraries, in the municipality of Chapecó -SC, considering assistance at the Care Center Psychosocial (CAPS II) and at the Family Health Center (CSF) Jardim América in the municipality of Chapecó/SC. The research has a qualitative nature and was carried out using a descriptive and exploratory approach, based on interviews and the application of questionnaires with pregnant or postpartum women diagnosed with anxious and/or depressive symptoms, within one period of childbirth. Data collection was carried out between March and June 2022. The data was analyzed using the content analysis technique. The project was submitted to Chapecó City Hall and the UFFS Research Ethics Committee. Among the eight women interviewed, six (75%) had, at some point, been diagnosed with depression and/or anxiety prior to pregnancy. As a therapeutic trajectory, six of the eight women interviewed reported improvements in symptoms after using medication. Two (25%) of the participants reported receiving comfort through religious practices. One (12.5%) respondent received psychological support during treatment. All (100%) participants underwent prenatal care in Primary Health Care (ABS). Finally, the present study provided a better understanding of the profile of women with depression and/or anxious symptoms during and after pregnancy. It is possible to understand the need for care and support for affected women, as treatment requires time and patience. Furthermore, family commitment is essential during the therapeutic process, as this contributes to the reduction of depressive and anxious symptoms during the peripartum period.

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“…Based on the ability of the SSRIs in causing malformations and changes in embryos reported by Magalhães et al;Nomura & Pinto e Silva (2007), we propose to examine embryological occurrence of possible changes in the development of TMJ, mainly in the condyle, of fetuses of rats, whose mothers were treated with fluoxetine.…”

Section: Introductionmentioning

confidence: 99%

Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine

et al. 2009

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The TMJ has been to the Dental community a key point in the search of knowledge, being it part of the temporomandibular joint complex and of the estomatognathic system which are in charge of the mastication, speech, swallowing, as well as participation in breathing and taste perception. For the majority of the women in serious state of depression, which do not respond psychotherapeutic treatment, pharmacological treatment it's applied. The antidepressants serotonin selective reuptake inhibitors (SSRIs) are the most recommended in these cases. The teratogenic effect of the SSRIs is considered controversial, studies done with women who used these drugs during the pregnancy showed that the respiratory and central nervous systems are the most affected, was also recorded a deficit of body growth and the decrease of the encephalon and skull measures. In the present study, our goal was to assess whether the administration of Fluoxetine during the pregnancy modified the embryology and morphology of the TMJ of rats. For that, 16 Wistar female rats from the Nutrition Department of the UFPE vivarium were selected; 8 for the control group, which received daily 0.9% of saline in subcutaneous dose of 10ml/g, with schedules previously established after daily weighing and 8 for the experimental one that were treated with fluoxetine hydrochloride with the dose of 10mg/Kg in a volume 10ml/g of weight, were injected subcutaneously with the same standards established for the control group. It was observed, with this dose that the embryological development of the TMJ, especially of the mandibular condyle, does not present any difference between the degree of maturation of the tissue that forms the TMJ, especially of the condyle between the treated and control groups.

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Riscos e benefícios do uso dos inibidores seletivos da recaptação de serotonina para a depressão durante a gravidez e a lactação

Cited by 5 publications

References 0 publications

Fluoxetine alters rat's milk properties causing impact on offspring's development

Fluoxetine alters rat's milk properties causing impact on offspring's development

Therapeutic Itineraries of Pregnant and Puerperous Women With Anxious and Depressive Symptoms, Up to One Year After Birth, in the Municipality of Chapecó – Sc

Morphological Aspects of the Embryonic Development of the TMJ in Rats (Rattus norvegicus albinus) Treated With Fluoxetine

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