As China's economic climate has developed, the nutritional status of elderly people in the rural parts of the country has improved in some aspects. However, the trend toward obesity will lead to a shift in the burden of obesity-related chronic diseases. In addition, rurally-located elderly people are at high risk of death that may be associated with abnormal serum cholesterol. The data also suggest that severe deficiencies in folate and vitamin B12 levels exist, as well as there being a high prevalence of hyperhomocysteinemia. Folate and vitamin B12 supplementation are necessary to prevent related diseases.
Fluoxetine is an antidepressant used to treat several conditions
including postpartum depression. This disease causes cognitive,
emotional, behavioral and physical changes, negatively affecting the
mother, child and family life. However, fluoxetine is excreted in breast
milk, causing short and long-term effects on children who were exposed
to the drug during lactation, so studies that seek to uncover these
consequences are needed. Thus, the aim of this study was to evaluate the
effects of fluoxetine on rat milk’s properties and on the physical and
neurobehavioral development of the offspring. Lactating rats were
divided into 4 groups: control group and three experimental groups,
which were treated with different doses of fluoxetine (1, 10 and 20
mg/kg) during the lactation. Dams body weight and milk properties were
measured, as well as offspring’s physical and neurobehavioral
development. Results showed that the use of fluoxetine during lactation
decreased dam’s body weight and alters milk’s properties, leading to
implications on the offspring growth until adulthood. Therefore, the use
of fluoxetine during lactation needs to be cautiously evaluated, with
the benefits to the mothers and the associated risk to the offspring
carefully balance.
ABSTRACT. Recent evidence suggests that genetic variations in the IGFBP-3 gene may impact susceptibility to colorectal cancer, but individually published results are inconclusive. Our meta-analysis was aimed at providing a more precise estimation of these associations. An extensive literature search was conducted for appropriate articles published before May 1, 2013. This meta-analysis was performed using the STATA 12.0 software. The crude odds ratios (OR) with 95% confidence interval (CI) were calculated. Eleven case-control studies were included with a total of 11,895 colorectal cancer patients and 17,147 healthy controls. Our meta-analysis indicated that the G variant of IGFBP-3 C2133G polymorphism may be associated with increased colorectal cancer risk. However, no statistically significant association was noted between IGFBP-3 A-202C polymorphism and colorectal cancer risk. No publication bias was detected in this metaanalysis. The current meta-analysis suggests that the IGFBP-3 C2133G polymorphism may confer susceptibility to colorectal cancer. The G IGFBP-3 A-202C and C2133G in colorectal cancer risk variant of the IGFBP-3 C2133G polymorphism may serve as a useful biomarker for predicting the risk of colorectal cancer.
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