Specific features of LPO processes and antioxidant defense were studied in patients with polycystic ovarian syndrome (PCOS) and infertility. Changes in LPO processes in patients with PCOS were compensatory, which manifested in increased α-tocopherol and retinol concentrations and moderate decrease in superoxide dismutase activity. Intensification of prooxidant processes was found in the group of patients with infertility without PCOS. The observed changes necessitate differentiated approach to the treatment of these patients.
Materials and methods. The article presents an assessment of the influence of factors on the effectiveness of cryoprenoses. Scientists conducted a retrospective analysis of 149 cryogenic transfer on the basis of the department of Auxiliary reproductive technologies of the Irkutsk Regional Perinatal Center for 2017. Patients signed voluntary consent to participate, the patients were divided into 4 groups, depending on the duration of storage of embryos: group 1 - 57 people, with a shelf life of 1-3 months, group 2 - 29 people, storage period 4-6 months, group 3 - 25 people, the shelf life is 7-11 months, group 4 - 38 people, the shelf life is 12 months or more. The average age of women is 30.69±2.9 years. Selection criteria for research: tubal factor of infertility, frozen embryos. Results. The analysis of cryopreference showed that the age of patients, the quality of transferred devitrified embryos and the duration of storage of cryopreserved embryos have a more important influence.
The article presents a literature review on the role of retinol as a component of the systemic metabolism affecting the reproductive system functioning and the consequences of its deficit. The paper presents the analysis of research works of FSBSI "Scientific Center of Family Health Problems and Human Reproduction" on studying reproductive health of the citizens of Eastern Siberia for the last 20 years as well as present knowledge on the relationship of low retinol level and reproductive disorders. Diagnostic results of 2 600 patients, including 2 200 with infertility and more than 400 teenagers from Russian and Buryat ethnic groups from rural areas and cities of Eastern Siberia, as well as the small peoples of the North: the Evenks and the Tofalars were analyzed. The authors found a decrease in the retinol concentration in blood serum of women and men with infertility as well as the growth of combined hormone-dependent diseases associated with a low content of this vitamin in women. The relationship between the content of retinol, а-tocopherol, thyroid hormones and some blood bioelements in women with infertility was detected. The article also presents data on the ethnic features of the metabolic status typical for the indigenous population - the Buryats and Tofalars. Retinol decrease in boys - Caucasians with hormonal disorders, residing in the industrial city was stated.
The aim of this research was to study the concentration of lipid peroxidation (LPO) products and the activity of antioxidant defense (AOD) parameters in ISIAH rats in comparison with a group of adolescents with arterial hypertension (AH). Material and Methods:We conducted the study on young (2.5-3 months) sexually mature male rats of the normotensive line (WAG) (n=20) (intact animals) and hypertensive line (ISIAH) (n=20), weighing 200-220 g. The data of 65 adolescents aged 13-17 years with AH (Group 1) were used for the clinical study (the age of adolescents is comparable to the biological age of the experimental animals used). The comparison group consisted of 65 normotensive adolescents of the same age and sex ("copypair" type) (Group 2). The plasma level of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactants [TBARs]) were determined using spectrophotometric and fluorometric methods.Results: We found that the course of LPO reactions in animals and humans was similar, which was expressed by the activation of prooxidant factors and the insufficiency of antioxidant response. Species differences concerned the intensity and number of parameters involved in the pathological process. Thus, in ISIAH rats there was an increase in toxic TBA-active products and a decrease in TTA, α-tocopherol and retinol in comparison with normotensive animals; in AH adolescents there was an increase in the content of intermediate-KD-CT and final TBA-active products, and a decrease in the α-tocopherol level in relation to the comparison group.Conclusion: Features of response of the LPO nonspecific system in hypertensive rats and humans allow using this line of rats for further study of adaptive mechanisms, and to extrapolate the received experimental data on humans, taking into account certain specific distinctions.(International Journal of Biomedicine. 2019;9(4):292-296.)
ART in anamnesis: in 2009, 2012, 2014. During the fourth ART program in 2016
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