No abstract

BackgroundFew studies have examined the effects of low‐dose alcohol consumption on the “lipid peroxidation‐antioxidant defense” (LPO‐AOD) system of mothers and infants, and on infant growth and development. This study examined effects of alcohol consumption on the LPO‐AOD system of pregnant women and newborns and infant development.MethodsA total of 209 pregnant women were recruited for this prospective study at the first prenatal visit and followed until delivery: 112 consumed alcohol and 97 reported no alcohol use during pregnancy. Infants were evaluated at birth, and at 6 and 12 months of age. The study controlled for the confounding effect of maternal smoking.ResultsBiomarkers of lipid peroxidation, for example, thiobarbituric acid reactants, were higher and the activity of the antioxidant defense system was lower in drinkers and their infants. Higher rates of pathological conditions and slower postnatal growth were observed among infants who were prenatally exposed to alcohol. Low‐dose alcohol use and tobacco smoking were associated with lower postnatal infant growth trajectories, resulting in restricted growth at 6 and 12 months among infants born to mothers who drank or smoked during pregnancy. Alcohol had a broad effect on the infant and maternal LPO‐AOD system, while the effect of smoking was limited in this study to maternal glutathione peroxidase.ConclusionsSmall amounts of alcohol consumed during pregnancy are associated with dysfunction of the LPO‐AOD system and development of oxidative stress in women and their children. Identification and preventive interventions are needed for pregnant women who use alcohol in any amount.

Materials and methods. The article presents an assessment of the influence of factors on the effectiveness of cryoprenoses. Scientists conducted a retrospective analysis of 149 cryogenic transfer on the basis of the department of Auxiliary reproductive technologies of the Irkutsk Regional Perinatal Center for 2017. Patients signed voluntary consent to participate, the patients were divided into 4 groups, depending on the duration of storage of embryos: group 1 - 57 people, with a shelf life of 1-3 months, group 2 - 29 people, storage period 4-6 months, group 3 - 25 people, the shelf life is 7-11 months, group 4 - 38 people, the shelf life is 12 months or more. The average age of women is 30.69±2.9 years. Selection criteria for research: tubal factor of infertility, frozen embryos. Results. The analysis of cryopreference showed that the age of patients, the quality of transferred devitrified embryos and the duration of storage of cryopreserved embryos have a more important influence.

The research objective is to determine the posterior probability of adverse cardiovascular events after elective coronary intervention in patients with ischemic heart disease (IHD) associated with type 2 diabetes, at high level of lipoprotein-associated phospholipase A2 (Lp-PLA2) in blood serum, as well as to find out the optimal separation point value for this predictor, which increase allows to identify high risk with accuracy.Material and methods. The 12-month cohort observational study included 60 patients (78% of men and 22% of women) with IHD associated with type 2 diabetes, aged 48–78. At the beginning of the study, along with conventional diagnostic techniques typical of a specialized cardiology clinic, the state of carbohydrate and lipid metabolism was analyzed and the proinflammatory status was evaluated (including assessment of Lp-PLA2 concentration by ELISA). At the end of the study distant results of treatment were assessed. The following events were taken into account: death of cardiovascular events, nonfatal myocardial infarction, nonfatal stroke, coronary revascularization (surgical, endovascular) due to restricture formation of a primary implanted stent or stricture formation of native coronary arteries, angina pectoris relapses.Results and discussion. The link between adverse cardiovascular events after elective percutaneous coronary intervention in patients with IHD type 2 diabetes-associated and high concentration of Lp-PLA2 in blood serum has been identified. Variation of the decision rule threshold on the performance curve has allowed to take Lp-PLA2 concentration of 983 ng/ml as a separation point. Accuracy of twoclass classification (determination of the posterior probability of adverse cardiovascular events) after identifying such separation point was characterized by 80% sensitivity and 100% specificity.Conclusion. The increase in the Lp-PLA2 concentration in blood serum (>983 ng/ml) may be considered as a predictor of adverse cardiovascular events after elective percutaneous coronary intervention in patients with IHD associated with type 2 diabetes.

ART in anamnesis: in 2009, 2012, 2014. During the fourth ART program in 2016

ЭФФЕКТИВНОСТЬ ПРИМЕНЕНИЯ ЭКЗОГЕННОГО ЛЮТЕИНИЗИРУЮЩЕГО ГОРМОНА В ЦИКЛАХ ВСПОМОГАТЕЛЬНЫХ РЕПРОДУКТИВНЫХ ТЕХНОЛОГИЙ Аннотация (Резюме). Исследовано 324 пациентки с трубно-перитонеальным бесплодием в циклах экстракорпорального оплодотворения (ЭКО). Все пациентки отнесены в 4 группы в зависимости от вида применяемого ЛГ-содержащего индуктора (мочевой или рекомбинантный) и дня его добавления в процессе стимуляции (со 2-3 или 6-7 дня). Оценивались параметры: возраст, состояние овариального резерва, продолжительность бесплодия, эффективность предыдущих попыток ЭКО, показатели индуцированного цикла (гормональный статус, количество фолликулов, состояние эндометрия), эмбриологический этап, частота наступления беременности (ЧНБ), «бедного ответа», синдрома гиперстимуляции яичников (СГЯ). Исследование показало, что высокие курсовые дозы гонадотропинов не снижают частоту «бедного» ответа. Протокол с добавлением рекомбинантного ЛГ со 2-3 дня стимуляции у пациенток позднего репродуктивного возраста способствует улучшению качества полученных ооцитов и эмбрионов, тем самым повышая частоту наступления беременности. ключевые слова: экстракорпоральное оплодотворение, экзогенный лютеинизирующий гормон, частота наступления беременности.

No abstract

The article provides an analysis of clinical, anamnestic and laboratory parameters for patients of young reproductive age who participated in IVF programs and have cryopreserved embryos. The main reasons for embryo cryopreservation were prevention of OHSS, "thin" endometrium and "previous IVF failures." It has been found that the patients from the group of transfer cancellation due to prevention of ovarian hyperstimulation had a higher ovarian reserve, a larger number of eggs, fresh and frozen embryos, and shorter shelf life of frozen embryos. All embryos were of the best quality (corresponding to the day of cultivation); the “post-thaw cultivation” technique was applied. During stimulation, lower amounts of gonadotropins were used. Patients with thin endometrium and previous IVF failures demonstrated slow growth of follicles, which required a higher course dose of gonadotropins with the addition of LH-containing preparations. Regardless of the group, in most cases, frozen/thawed embryos were transferred at the blastocyst stage (Day 5). The pregnancy rate was high in patients at risk of OHSS and with thin endometrium (48.6%, 48.0%). Patients with IVF failures had a lower pregnancy rate; this is due to endometrial pathology in the medical history, a smaller number of antral follicles, oocytes, fresh and frozen embryos, and longer shelf life of frozen embryos.