Specific features of LPO processes and antioxidant defense were studied in patients with polycystic ovarian syndrome (PCOS) and infertility. Changes in LPO processes in patients with PCOS were compensatory, which manifested in increased α-tocopherol and retinol concentrations and moderate decrease in superoxide dismutase activity. Intensification of prooxidant processes was found in the group of patients with infertility without PCOS. The observed changes necessitate differentiated approach to the treatment of these patients.
The aim of this research was to assess lipid peroxidation (LPO) and antioxidative defense (AOD) changes in adolescent boys with obesity using the integral index. Materials and Methods: We examined 19 adolescent boys with obesity of the first degree (the study group). The control group included 23 healthy adolescent boys. The study included the collection of anamnestic data, physical examination, and anthropometric data analysis (body weight (BW), height, waist circumference (WC), hip circumference (HC), and body mass index (BMI)). Laboratory analysis included an assessment of the blood levels of total cholesterol, triglycerides, HDL, LDL, and glucose, as well as the intensity of LPO and AOD in blood plasma and primary and secondary products of LPO. To measure the intensity of OS, the oxidative stress index (OSi) was calculated (the ratio of the LPO-AOD system indicators in the study group to average indicators in the control group). Results: We found a statistically significant increase in BW, BMI, SDS BMI, WC, and HC in the study group compared to the control group. The obese patients had higher values of blood glucose, total cholesterol, triglycerides and LDL compared to the control group. In the study group, we found a significant decrease in the concentration of diene conjugates and an increase in the level of ketodienes and conjugated trienes. The values of α-tocopherol and retinol, and SOD activity were significantly decreased in the study group compared to the control group. There were no statistically significant changes in total antioxidant activity and glutathione status components. According to the data received, the OSi level in the group of obese patients increased approximately 7 times, which confirms the results on the development of antioxidant insufficiency in this pathology.
We studied the state of the LPO-antioxidant defense system in men aged from 46 to 55 years. The main group included patients with obstructive sleep breathing disorders. The state of the antioxidant defense system was assessed by measuring the blood levels of LPO substrates with conjugated double bonds, conjugated dienes, ketodienes and conjugated trienes, MDA, retinol, α-tocopherol, reduced and oxidized glutathione, SOD activity, and the level of total antioxidant activity of blood. Calculation of antioxidant potential helps to identify the processes of "oxidative stress" in the main group, which is a pathogenetic substantiation for including antioxidant drugs in the complex therapy of patients with OSBD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.