Retinol Content and Reproductive Disorders in Residents of Eastern Siberia (Literature Review)

Лабыгина, А. В.; Kolesnikova, L. I.; Grebenkina, Lyudmila; Darenskaya, M. A.; Курашова, Н. А.; Dolgih, M. I.; Semenova, Natalya; Natyaganova, L. V.; Дружинина, Е. Б.

doi:10.33396/1728-0869-2018-4-51-58

Cited by 4 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Biochemical studies of human reproductive function and its disorders in recent decades have been characterized by the development of "cost-effective" universal technologies that allow us to give an integral assessment and outline some sanogenetic ways to correct disorders in reproductive function. It is necessary to highlight the research concerning the polyvalent function of LPO and AOD factors, (23) which prevent the development of OS and positively affect the complex treatment of endocrine forms of female infertility. (24,25) The increased intensity of LPO, as a possible result of neurohumoral shifts, in many cases is either a consequence or cause of certain pathological changes in cells and tissues.…”

Section: Resultsmentioning

confidence: 99%

Analysis of Pro- and Antioxidant Status in Women with Endocrine Infertility

Grebenkina¹,

Darenskaya²,

Rashidova³

et al. 2020

IJBM

View full text Add to dashboard Cite

The aim of our study was to identify the changes in the indicators of lipid peroxidation (LPO) and antioxidant defense (AOD) in women with endocrine infertility. Methods and Results: The study included 358 women of reproductive age. Based on clinical and laboratory data, two groups were formed: the control group (CG) and the main group (MG). CG consisted of 61 healthy fertile women (mean age of 22±2.3 years). MG consisted of 297 women (mean age of 26±5.6 years) with endocrine infertility. The blood levels of antioxidant parameters (total antioxidant activity [TTA], SOD activity, α-tocopherol and retinol) and primary/secondary products of LPO (conjugated dienes [CD], ketodienes and conjugated trienes [KD-CT], and thiobarbituric acid reactants [TBARs]) were determined using spectrophotometric and fluorometric methods. The levels of sex hormones and cortisol were determined by radioimmunoassay and EIA. In MG, we found a significant increase in the blood levels of total lipid, DB, CDs, KD-CT, and TBARs, compared to CG. The results of a comparative analysis of the AOD parameters showed a significant increase in the total AOA level by 31% in MG, while the levels of α-tocopherol and retinol significantly decreased by 22% and 15%, respectively, compared to CG. In women of MG, the serum level of prolactin increased by 2 times. Conclusion: The results obtained reflect the adaptive and disadaptive mechanisms of LPO-AOD participation in the formation of female infertility of endocrine origin. The complex changes in the LPO-AOD system (increased levels of the substrates of oxidation and all intermediates of the LPO process amid falling values of the AOD parameters) indicate the presence of OS in women with endocrine infertility.

show abstract

Section: Resultsmentioning

confidence: 99%

Analysis of Pro- and Antioxidant Status in Women with Endocrine Infertility

Grebenkina¹,

Darenskaya²,

Rashidova³

et al. 2020

IJBM

View full text Add to dashboard Cite

show abstract

Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission

et al. 2023

View full text Add to dashboard Cite

Ethnic features of antioxidant status in men with infertility

Курашова

Dashiev

Kolesnikova

2022

Ekologiya cheloveka (Human Ecology)

View full text Add to dashboard Cite

The study of the influence of the ethnic factor on human health is relevant at the present time. Objective: to evaluate the antioxidant status of blood and ejaculate in infertile men in different ethnic groups. Methods. A retrospective analysis was made of the results of a survey of 222 Caucasians and 143 Mongoloids with pathozoospermia from infertile couples. The control groups were parktically healthy men with realized reproductive function (97 - Mongoloids and 104 - Caucasians). The material for biochemical studies was blood plasma and ejaculate. The work used spectrophotometric, fluorometric and statistical methods of research. In the blood and ejaculate of the examined men, the total antioxidant activity was determined as an indicator characterizing the total activity of lipid peroxidation inhibitors and determining its buffer capacity, the concentration of fat-soluble vitamins retinol and -tocopherol, and the level of superoxide dismutase. Results. In the blood of infertile Caucasian men, compared with fertile donors, a decrease in the concentration of retinol by 27% (p0.0001) and -tocopherol by 25% (p0.0001), as well as the activity of superoxide dismutase by 5% (p= 0.0002). In the ejaculate of male Caucasians with infertility, a decrease in the concentration of -tocopherol by 17% (p=0.0006) and an increase in total antioxidant activity by 21% (p=0.0004) were found. The antioxidant defense system in Mongoloid men is characterized by an increase in retinol concentration by 24% (p=0.0002) and total antioxidant activity by 13% (p=0.026), against the background of a decrease in superoxide dismutase activity by 8% (p0.0001).The results of the study of the antioxidant defense system in the ejaculate of Mongoloid men with infertility showed a decrease in the concentration of -tocopherol by 15% (p=0.03) and an increase in the level of total antioxidant activity by 17% (p=0.04). Conclusions. When one or more components of the antioxidant system are deficient, cells lose their ability to protect against the action of reactive oxygen species, which invariably leads to damage to tissues, organs, and organ systems. Assessment of the state of the antioxidant status in men of different ethnic groups has an important prognostic value in the study of reproductive health, contributes to the knowledge of the pathogenetic processes of the disease for personalized diagnosis, prevention and correction.

show abstract

Retinol Content and Reproductive Disorders in Residents of Eastern Siberia (Literature Review)

Cited by 4 publications

References 6 publications

Analysis of Pro- and Antioxidant Status in Women with Endocrine Infertility

Analysis of Pro- and Antioxidant Status in Women with Endocrine Infertility

Features of the Free Radical Oxidation Process and Antioxidant System in Newborns Born to HIV-Infected of Mothers Who Received Antiretroviral Therapies to Prevent HIV Transmission

Ethnic features of antioxidant status in men with infertility

Contact Info

Product

Resources

About