Interstitial changes in the lungs could be caused by vast majority of diseases including tuberculosis, sarcoidosis, hypersensitive pneumonitis, metastatic injury of the lungs, etc. Differential diagnosis of pulmonary dissemination remains an urgent and challenging clinical task. This article is a review of published literature and presentation of a clinical case of a patient with interstitial lung disease. The case demonstrates diagnostic difficulties in identification the cause of interstitial lung injuries. Interstitial lung injury was incidentally found in this patient and initially was considered as disseminated pulmonary tuberculosis. In-depth diagnostic work-up including lung tissue biopsy allowed diagnosis of lymphoid interstitial pneumonia associated with common variable immune deficiency. This case demonstrates common misdiagnosis of pulmonary tuberculosis in a patient with interstitial lung injury.
A combination of factors, including Western European eating habits, physical inactivity and genetic predisposition, lead to a dramatic increase in adipose tissue mass. A special place is occupied by abdominal obesity, in which there is an accumulation of adipose tissue in the mesentery of the small intestine and the omentum. Developing in conditions of visceral obesity, insulin resistance, dyslipidemia and systemic inflammation are one of the key components of the pathogenesis of type 2 diabetes mellitus, cardiovascular diseases, non-alcoholic fatty liver and pancreas disease, polycystic ovary disease, some forms of cancer (breast cancer, endometrial cancer, colonic and direct intestines). At the same time, the pathogenetic role of adipose tissue is not limited to its participation in the formation of the cardiometabolic continuum and oncogenesis. The most important role of metabolically active fat in the pathogenesis of many respiratory diseases is known, including bronchial asthma, obstructive sleep apnea and pulmonary hypertension. This paper presents an overview of current data on immunological, pathophysiological and clinical features of the phenotype of the combination of respiratory diseases with overweight and obesity.
Схожесть рентгено-морфологических изменений, отсутствие специфических симптомов зачастую приводит к ошибочной диагностике туберкулеза у пациентов с другими гранулематозными заболеваниями легких. Статья посвящена проблеме дифференциальной диагностики туберкулеза и гранулематоза с полиангиитом. Сформулированы основные причины диагностических ошибок, и приведена схема диагностики системного васкулита.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.