The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut’s immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article.
In this work, a chemiluminescence (CL) method based on dual aptasensors using Fe3O4 and SiO2 nanoparticles (NPs) as carriers is developed for the simultaneous detection of ochratoxin A (OTA) and adenosine triphosphate (ATP) in beer.
China is attaching increasing importance to the creation of regional integration, high-quality economic development and ecological civilization. An accurate grasp of the traction effect of the increased level of integration of urban agglomerations on the eco-efficiency (EE) of cities in the region will help to promote the steady improvement of urban economic development and the ecological environment. This paper constructs an index system to measure the level of integration of the Chengdu–Chongqing urban agglomeration (CCUA) and the EE of each city within it from 2011 to 2020 and explores the impact of regional integration on urban EE and its mechanism of action. The study presents the follow findings: (1) The level of integration of the CCUA increased nearly 10 times from 2011 to 2020, with the government playing a significant leading role. (2) The positive and negative effects of the level of integration of the CCUA on urban EE depend on factors such as the level of economic development, the stage of development and the location. There are several relationships between the level of intra-regional integration and urban EE: first, a nearly linear increase, as in Chongqing and Chengdu; second, an increase in fluctuation, as in Dazhou, Guang’an and Leshan; and third, a fluctuation, decrease, flat or even no real increase, as in Luzhou, Ya’an and Zigong. (3) Based on this, this paper considers the mechanism of the level of integration within the region on urban EE in terms of both economic and eco-environmental effects, with a view to exploring the future green development path of the CCUA.
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