NLRP3 and Gut Microbiota Homeostasis: Progress in Research

Pan, Hongming; Jian, Yuting; Wang, Feijie; Yu, Shaokun Carol; Guo, Jianchun; Kan, Juntao; Guo, Wei

doi:10.3390/cells11233758

Cited by 19 publications

(10 citation statements)

References 59 publications

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“…A strong correlation between intestinal flora and diabetes began to reveal. Recent studies have shown that the intestinal flora plays an important role in maintaining gut homeostasis, especially in the regulation of inflammation (5). Through the interaction with dietary components, it affects intestinal permeability, glucose homeostasis, insulin sensitivity, glucose lipid metabolism and so on (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora

et al. 2023

Front. Endocrinol.

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Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that Inonotus obliquus possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties. In this research, we aim to investigate the potential treatment outcomes of Inonotus obliquus for T2DM and discuss its favourable influences on the intestinal flora. The chemical composition of Inonotus obliquus methanol extracts (IO) was analyzed by ultra-high-performance liquid chromatography-Q extractive-mass spectrometry. IO significantly improved the blood glucose level, blood lipid level, and inflammatory factor level in T2DM mice, and effectively alleviated the morphological changes of colon, liver and renal. Acetic acid, propionic acid, and butyric acid levels in the feces of the IO group were restored. 16S rRNA gene sequencing revealed that the intestinal flora composition of mice in the IO group was significantly modulated. Inonotus obliquus showed significant hypoglycemic and hypolipidemic effects with evident anti-inflammatory activity and improved the morphological structure of various organs and cells. Inonotus obliquus increased the levels of short-chain fatty acids in the environment by increasing the population of certain bacteria that produce acid, such as Alistipes and Akkermansia, which are beneficial to improve intestinal flora disorders and maintain intestinal flora homeostasis. Meanwhile, Inonotus obliquus further alleviated T2DM symptoms in db/db mice by down-regulating the high number of microorganisms that are dangerous, such as Proteobacteria and Rikenellaceae_RC9_gut_group and up-regulating the abundance of beneficial bacteria such as Odoribacter and Rikenella. Therefore, this study provides a new perspective for the treatment of T2DM by demonstrating that drug and food homologous active substances could relieve inflammation via regulating intestinal flora.

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Section: Introductionmentioning

confidence: 99%

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora

et al. 2023

Front. Endocrinol.

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“…NLRP3 Inflammasome can recognize a wide range of stimuli in vitro and in vivo, and release inflammatory cytokines, which can trigger inflammation. NLRP3 inflammasome plays an important role in maintaining the intestinal health by protecting ( Pan et al, 2022 ). However, chronical or excessive activation of NLRP3 inflammasome can lead to various inflammatory diseases ( Zheng et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Dietary tryptophan alleviates intestinal inflammation caused by long photoperiod via gut microbiota derived tryptophan metabolites-NLRP3 pathway in broiler chickens

Ma,

Zhang,

Zhang

et al. 2024

Poultry Science

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“…As mentioned earlier PRRs, such as TLRs and nucleotide-binding oligomerization (NOD)-like receptors (NLRs) amongst many others, also sense microorganisms through PAMPs like lipopolysaccharide (LPS), lipoproteins, peptidoglycan, and lipoteichoic acid (LTA) to control homeostatic tolerance to commensal microbes and host responses to potential microbial threats [16]. Recognition of LTA and LPS from various gram-positive and gram-negative microbes activates TLRs and drives GIM-related inflammation after formation and activation of the NLRP3 inflammasome and pyroptotic cell death [20 ▪ ]. Activation of NF-ĸB by TLR signaling through MyD88-dependent and -independent pathways is another important mechanism of inflammation.…”

Section: Gastrointestinal Mucositis As Sign Of Local Inflammationmentioning

confidence: 99%

Gastrointestinal mucositis: a sign of a (systemic) inflammatory response

Blijlevens,

Reijnders,

Molendijk

2024

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of review Gastrointestinal mucositis (GIM) is a significant complication of cancer therapy. Whilst inflammation is a central feature of GIM, studies attempting to mitigate mucosal damage via this mechanism are scarce. This review describes the relation between GIM, local and systemic inflammation, and the microbiome and its metabolites, and explores recent research on therapeutics that target this relationship. Recent findings Recent literature underscores the pivotal role of inflammation in GIM, elucidating its bidirectional relation with disturbance of the gut microbiota composition and intestinal permeability. These events cause a heightened risk of bloodstream infections and lead to systemic inflammation. While studies investigating risk prediction models or therapeutics targeting GIM-related inflammation remain scarce, results have shown promise in finding biomarkers and alleviating GIM and its accompanying clinical symptoms. Summary The findings underscore the important role of inflammation and the microbiome in GIM. Understanding the inflammatory pathways driving GIM is crucial for developing effective treatments. Further research is needed using genomics, epigenomics, and microbiomics to explore better risk prediction models or therapeutic strategies aimed at mitigating GIM-related inflammation.

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NLRP3 and Gut Microbiota Homeostasis: Progress in Research

Cited by 19 publications

References 59 publications

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora

Dietary tryptophan alleviates intestinal inflammation caused by long photoperiod via gut microbiota derived tryptophan metabolites-NLRP3 pathway in broiler chickens

Gastrointestinal mucositis: a sign of a (systemic) inflammatory response

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