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BackgroundsThe maxillary anterior teeth play a crucial role in smile aesthetics. As for maxillary lateral incisors, most studies concentrated on its size, incisor edge level, inclination, et al. However, the aesthetic effect of lateral incisor movement in spatial position has not been studied yet. Therefore, the purpose of this study was to explore the influence of labiolingual position of maxillary lateral incisors on the aesthetic perception of orthodontists and laypersons and different gender groups.MethodsA photograph of a male's smile was selected. iOrtho7.0 software (Time Angel, Wuxi, China) was used to edit the three dimensional (3D) dental models. By referring to the 3D models, the photograph was digitally processed to create seven images with different labiolingual positions of the maxillary lateral incisors in 0.5 mm increments (+ indicates labial movement and -indicates lingual movement). Eighty-six orthodontists and one hundred sixty-one laypersons were asked to evaluate images using a visual analog scale. Data were analyzed by Student t-test and One-way analysis of variance with post hoc test.ResultsThere was no significant difference between the perception of males and females (P > 0.05). Orthodontists assigned lower scores to all images than laypersons. +1.5 mm was considered as the least attractive smile by orthodontists while + 1.5 mm and − 1.5 mm were regarded as the least attractive ones by laypersons. 0 mm was rated the most attractive by all judges (P < 0.05). Between the 0 mm and − 0.5 mm, laypersons observed the difference but orthodontists did not.ConclusionsThe labiolingual position of maxillary lateral incisors does affect the perception of smile esthetics. Although orthodontists gave lower score to each image than laypersons.

Background We sought to establish a prospective hospital-based cohort, featuring detailed multidimensional data of trauma patients with active follow-ups, which can be a reliable data source for all studies focusing on the effects or underlying mechanistic pathways of environmental and biological factors on multiple interested trauma-related outcomes, particularly the incidence and trajectory of trauma-related psychopathology, in a Chinese population. Methods The China Severe Trauma Cohort (CSTC) enrolled all traumatized individuals aged 12 to 80 years admitted to the Trauma Center of West China Hospital between March 1 st , 2020 and July 8 th , 2022. The bio-sample and detailed questionnaire data were collected at recruitment, and phone/internet follow-ups were scheduled at 1, 3, 6, and 12 months after the baseline. Long-term health outcomes are planned to be obtained from administrative databases through data linkage. Results A total of 2,500 trauma patients were enrolled (response rate = 87.1%) with an average age of 46.01 years, and most of the participants were males (62.6%). The proportions of participants with blood and fecal sample collected at baseline were 93.8% and 66.3%, respectively. As of August 31 st , 2022, the follow-up rate was 90.0%, 77.0%, 76.5%, and 89.0% for 1-, 3-, 6-, and 12-month follow-ups, respectively. Fall/wrench (47.6%) and traffic accident (26.2%) were the top causes of current trauma. The most common psychopathology at recruitment was sleep disturbance (39.4%), followed by depression (22.6%), anxiety (18.2%), and acute stress reaction (7.8%), all of which showed recovering trajectories during the follow-up period, particularly the first 3 months after baseline. Conclusion CSTC provides a platform with multidimensional data to study both short-term and long-term trauma-related health consequences, prompting early identification and intervention for individuals with high risk of health decline after trauma exposures.

Prior evidence suggests that physical activity may reduce the risk of multiple diseases and mortality. However, whether and how physical activity affects the aging process remains largely unexplored. We included 284,479 UK Biobank participants and computed leukocyte telomere length (LTL) deviation (i.e., the difference between genetically determined and observed LTL) and biological age acceleration (BAA, defined as the discrepancy between the phenotypic age of a person and the average phenotypic age in the cohort of individuals with the same age and sex) as the indexes for aging acceleration. Linear and logistic models were used to estimate the associations of self-reported physical activity items and patterns (identified by principal component analysis), as well as accelerometer-assessed physical activity, with aging acceleration. Analyses of physical activity patterns indicated, a higher level of adherence to activity patterns predominated by strenuous sports, other exercises, walking for pleasure, heavy and light housework, and public transportation use was associated with a lower risk of aging acceleration, whereas a higher level of adherence to patterns predominated by job-related activities was associated with a higher risk of aging acceleration. Analysis among 62,418 participants with accelerometer-measured physical activity corroborated these results. Physical activity, such as strenuous sports and other exercises at leisure time and use of public transportation, was associated with a reduced biological aging. Besides highlighting the importance of engaging in physical activity for healthy aging, our results provide further evidence for the beneficial effect of physical activity on the telomere attrition process.