Cohort Profile: The China Severe Trauma Cohort (CSTC)

Abstract

Background We sought to establish a prospective hospital-based cohort, featuring detailed multidimensional data of trauma patients with active follow-ups, which can be a reliable data source for all studies focusing on the effects or underlying mechanistic pathways of environmental and biological factors on multiple interested trauma-related outcomes, particularly the incidence and trajectory of trauma-related psychopathology, in a Chinese population. Methods The China Severe Trauma Cohort (CSTC) enrolled all traumatized individuals aged 12 to 80 years admitted to the Trauma Center of West China Hospital between March 1 st , 2020 and July 8 th , 2022. The bio-sample and detailed questionnaire data were collected at recruitment, and phone/internet follow-ups were scheduled at 1, 3, 6, and 12 months after the baseline. Long-term health outcomes are planned to be obtained from administrative databases through data linkage. Results A total of 2,500 trauma patients were enrolled (response rate = 87.1%) with an average age of 46.01 years, and most of the participants were males (62.6%). The proportions of participants with blood and fecal sample collected at baseline were 93.8% and 66.3%, respectively. As of August 31 st , 2022, the follow-up rate was 90.0%, 77.0%, 76.5%, and 89.0% for 1-, 3-, 6-, and 12-month follow-ups, respectively. Fall/wrench (47.6%) and traffic accident (26.2%) were the top causes of current trauma. The most common psychopathology at recruitment was sleep disturbance (39.4%), followed by depression (22.6%), anxiety (18.2%), and acute stress reaction (7.8%), all of which showed recovering trajectories during the follow-up period, particularly the first 3 months after baseline. Conclusion CSTC provides a platform with multidimensional data to study both short-term and long-term trauma-related health consequences, prompting early identification and intervention for individuals with high risk of health decline after trauma exposures.

Postsurgery Subjective Cognitive and Short-Term Memory Impairment Among Middle-Aged Chinese Patients

“…The CSAC is an ongoing multicenter cohort study recruiting patients aged 40 to 65 years who underwent elective surgery and general anesthesia in 4 medical centers in China (3 hospitals in Sichuan and 1 in Hebei Province) since July 15, 2020. Details of the CSAC have been reported elsewhere 17 (eMethods and eFigure 1 in Supplement 1 ). Until March 31, 2023, a total of 11 814 eligible surgery patients were invited to participate, among whom 11 158 were successfully recruited into this study (response rate, 94.4%).…”

Genome-wide association study suggests that CPQ influences the Omicron variant COVID-19 severity

“…The China Surgery and Anesthesia Cohort (CSAC) and The China Severe Trauma Cohort (CSTC), both launched in June-July 2020. Detailed study designs for the two cohorts have been previously described 12,13 . In brief, the CSAC was conducted in four medical centers in China, with the primary objective of recruiting adults aged 40 to 65 years who underwent elective surgery and general anesthesia.…”

“…The current GWAS combined samples from two ongoing multicenter longitudinal cohorts in China: The China Surgery and Anesthesia Cohort (CSAC) and The China Severe Trauma Cohort (CSTC) 12,13 . After the massive Omicron outbreak in China, COVID-19 related information was collected for both cohorts since March 2023 with standardized questionnaire (Supplementary Methods) measuring infection status, medical treatment received, and symptoms experienced during and after the infection.…”