Multifunctional nanomaterials for dual-mode imaging guided cancer therapy are highly desirable in clinical applications. Herein, a flowerlike NiS 2 -coated NaLuF 4 :Nd (Lu:Nd@NiS 2 ) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). The material was then loaded with phenolic epigallocatechin 3-gallate (EGCG), which is a natural heatshock protein 90 (HSP90) inhibitor. Upon near infrared irradiation, EGCG was released from the Lu:Nd@NiS 2 -EGCG, which bound HSP90 and reduced cell tolerance to heat, resulting in a better therapeutic effect at the same elevated temperature. Therefore, with minimal side effects and remarkable antitumor efficacy in vivo, Lu:Nd@NiS 2 -EGCG appeared to be a promising photothermal agent for enhanced PTT.
We explore the feasibility of a novel pyrogallic acid–titanium(iv) complex-modified upconversion nanoprobe (UCNP–PA–Ti) for F– capture and real-time quantification.
Multichannel
near-infrared (NIR)-II imaging provides more precise
and detailed information for studying complex biological processes.
When studying specific biological processes, a separated single signal
and multisignals are essential but difficult to obtain by traditional
multichannel NIR-II imaging methods. Taking advantage of the unique
optical properties of lanthanide ions, especially in atom-like absorbance
and emission spectroscopy in the NIR region, in this study, we synthesized
two lanthanide-doped nanoprobes, NaYF4:Gd@NaYF4:Nd@NaYF4 (cssNd) and NaYF4:Gd@NaYF4:Er@NaYF4 (cssEr). These two nanoprobes show orthogonal
NIR-II emissions (1064 and 1330 nm for cssNd and 1550 nm for cssEr)
under 730 and 980 nm excitation, respectively. The feasibility of
cssNd and cssEr for multichannel NIR-II imaging was proven in vitro. Under different methods of administering the nanoprobes, in vivo multichannel NIR-II imaging with both the separated
single signal and multisignals was successfully performed and could
spatially distinguish tissues under two different excitation sources.
Our results provide a new method for multichannel NIR-II imaging with
separable signals, which is promising for precisely studying complex
biological processes precisely.
The NaErF4@NaLuF4 and NaYF4:Nd@NaLuF4 emitted orthogonal shortwave infrared (SWIR) lights, which were separated by optical filter, applied in invisible logical codes and interference-free bio-imaging.
Information storage in vivo will lead to next-generation
identification
and security authentication. Here, an information storage method was
proposed for in vivo application by using a pair of lanthanide-doped
nanoprobes (NdNPs and ErNPs) with orthogonal emissions in the second
near-infrared window. The information is stored in different fluorescence
channels separately, while the selective readout could be realized
by simply manipulating excitation wavelengths. The small-animal experiments
primarily confirm the applicability of this method in vivo. The binary
numbers ″1″ and ″0″ are implanted under
the mice’s skin, and the corresponding signals ″on″
and ″off″ can be collected by charge-coupled devices
under different laser filter combinations. The design of lanthanide-doped
probes with the nanoscale features and orthogonal emissions is expected
to provide a new strategy for information storage in vivo. The lanthanide
materials with excellent down-conversion near-infrared fluorescence
performance have shown great application potential in the field of
photonics.
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