Biocompatible Heat-Shock Protein Inhibitor-Delivered Flowerlike Short-Wave Infrared Nanoprobe for Mild Temperature-Driven Highly Efficient Tumor Ablation

Abstract

Multifunctional nanomaterials for dual-mode imaging guided cancer therapy are highly desirable in clinical applications. Herein, a flowerlike NiS 2 -coated NaLuF 4 :Nd (Lu:Nd@NiS 2 ) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). The material was then loaded with phenolic epigallocatechin 3-gallate (EGCG), which is a natural heatshock protein 90 (HSP90) inhibitor. Upon near infrared irradiation, EGCG was released from the Lu:Nd@NiS 2 -EGCG, which bound HSP90 and reduced cell tolerance to heat, resulting in a better therapeutic effect at the same elevated temperature. Therefore, with minimal side effects and remarkable antitumor efficacy in vivo, Lu:Nd@NiS 2 -EGCG appeared to be a promising photothermal agent for enhanced PTT.

Low-Temperature Photothermal Therapy: Strategies and Applications

“…In addition, 2-phenylethynesulfonamide (PES), famous for disturbing HSP70 activity via multiple cell signaling pathways with excellent specificity and negligible cytotoxicity, was introduced into a poly(3,4-ethylenedioxythiophene)- (PEDOT-) encapsulated thermoresponsive nanogel composed of poly( N -isopropylacrylamide- co -acrylic acid) (PNIPAM) by Liu et al [ 103 ]. To meet the requirements of real-time diagnosis, Jiang et al fabricated a flower-like NiS 2 -coated NaLuF 4 :Nd (Lu:Nd@NiS 2 ) NP for short-wave infrared light imaging and MRI-guided PTT through using epigallocatechin gallate (EGCG) that can suppress HSP90 activity [ 104 ]. This NP showed satisfactory antitumor efficacy via low-temperature PTT and could be employed as an outstanding theranostic nanoplatform.…”

Improvement of Gold Nanorods in Photothermal Therapy: Recent Progress and Perspective

“…The full development of nanotechnology in pharmaceutical products still requires efforts to transform it from a laboratory environment to a clinical application. Because toxicity accounts for 20% of all drug failures in clinical trials, it must be considered as potential factors for the failure of nanomaterials (Kola and Landis 2004), and the local therapeutic nanocomposites with the advantage of low systemic toxicity exhibit a more promising prospect (Jiang et al, 2019). Therefore, recent research on reducing the systemic toxicity of GNRs and prolonging their blood circulation time, enhancing the therapeutic effect, is introduced.…”

Application of green tea extracts epigallocatechin‐3‐gallate in dental materials: Recent progress and perspectives

“…Many studies have synthesized materials combined with EGCG and investigated their influence on the whole body. Such as multifunctional nanomaterials for tumor therapy (Jiang et al, 2019), polymer particles for antioxidant action (Seo et al, 2017), targeted nanoparticles for anti‐atherosclerosis (Zhang et al, 2019), self‐assembled nanogels for resistant breast cancer therapy (Ding, Liang, Min, Jiang, & Zhu, 2018), Co‐delivery system of natural compounds and dual‐target nanoparticles for improving in situ tumor models (Chu, Tsai, Ko, Wu, & Lin, 2019), dual‐drug nanoparticles for the treatment of Alzheimer's disease (Cano et al, 2019), and so forth.…”