Green synthesis of ultra-small VOx nanodots for acidic-activated HSP60 inhibition and therapeutic enhancement

Mao, Fang; Liu, Yuxin; Ma, Longhua; Liu, Lidong; Jiang, Anqi; Zhai, Xuejiao; Zhou, Jing

doi:10.1016/j.biomaterials.2018.12.022

Cited by 22 publications

(13 citation statements)

References 41 publications

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“…The V 2p spectrum of TA@VO x NSs was deconvoluted into four components with binding energies of about 524.95, 523.71, 517.71, and 516.55 eV, which were assigned to V 5+ 2p 1/2 , V 4+ 2p 1/2 , V 5+ 2p 3/2 , and V 4+ 2p 3/2 , respectively (Figure 1 c). Referring to the previous studies on VO x nanodots, [17] the proportion of V 4+ was 66.5 %, and that of V 5+ was 33.5 % from the V 2p spectrum of TA@VO x NSs. Further, on the basis of the proportion of V 4+ and V 5+ , the percentage of x in VO x is 2.25 ( x= 2.25 in TA@VO x NSs).…”

Section: Resultsmentioning

confidence: 53%

“…However, the fabrication of multifunctional vanadium oxidebased therapeutic nanozymes is very challenging. [17] First, the peroxidase-like activity is strongly influenced by the structure, dispersion, and the valences of vanadiumo xides, [18] meanwhile, the structure and dispersion of vanadium oxidesa re strongly affected by the support material. [18b, 19] Therefore,t he support materiala nd the surface-supported vanadium sites are crucial to design nanozymes for therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

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Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

Chen

Huang

Liang

et al. 2020

Chemistry A European J

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The selection of suitable nanozymes with easy synthesis, tumor specificity,m ultifunction,a nd high therapeutics is meaningful for tumor therapy.H erein, af acile onestep assembly approach was employed to successfully prepare an ovel kind of naturalp olyphenol tannic acid (TA) hybrid with mixed valence vanadium oxide nanosheets (TA@VO x NSs). In this system, VO x is assembled with TA through metal-phenolic coordination interaction to both introduce superior peroxidase-like activity and high near infrared (NIR) absorption owing to partial reduction of vanadium from V 5 + to V 4 + .T he presence of mixed valencev anadium oxide in TA@VO x NSs is proved to be the key for the catalytic reaction of hydrogen peroxide (H 2 O 2)t oCOH, and the corre-spondingc atalytic mechanism of H 2 O 2 by TA@VO x NSsi s proposed. Benefitting from such peroxidase-like activity of TA@VO x NSs, the overproduced H 2 O 2 of the tumor microenvironmenta llows the realization of tumor-specific chemodynamic therapy (CDT). As av alid supplementt oC DT,t he NIR absorption enables TA@VO x NSs to have NIR light-mediated conversion ability for photothermal therapy(PTT) of cancers. Furthermore, in vitro and in vivo experimentsc onfirmed that TA@VO x NSs can effectively inhibit the growth of tumors by synergistic CDT/PTT.T hese resultso ffer ap romising way to develop novel vanadium oxide-based nanozymes for enhanced synergistic tumor-specific treatment.

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Section: Resultsmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

Chen

Huang

Liang

et al. 2020

Chemistry A European J

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“…Subsequently, four different mixed-valence vanadium oxide nanozymes were obtained by constantly adjusting the amount of NaBH 4 . 35 The SEM and TEM images indicated that Vnps-I, Vnps-II, and Vnps-III are small round particles with a particle size of about 10 nm. Vnps-IV had an irregular nanosheet structure with a particle size of about 55 nm (Figure 1A−D and Figure S1, Supporting Information).…”

Section: Synthesis and Characterization Of Vnps-xmentioning

confidence: 96%

Vanadium Oxide Nanozymes with Multiple Enzyme-Mimic Activities for Tumor Catalytic Therapy

Zeng

Wang

et al. 2023

ACS Appl. Mater. Interfaces

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Using tumors containing high concentrations of hydrogen peroxide to design nanozymes is a new and effective strategy, and vanadium-based nanomaterials receive increasing attention. In this paper, four kinds of vanadium oxide nanozymes with different valences of vanadium are synthesized by a simple method to verify the effect of valence on enzyme activity. Vanadium oxide nanozyme-III (Vnps-III) with a low valence of vanadium (V4+) exhibits good peroxidase (POD) and oxidase (OXD) activities, which can effectively produce reactive oxygen species (ROS) in the tumor microenvironment for tumor treatment. In addition, Vnps-III can also consume glutathione (GSH) to reduce ROS consumption. Vanadium oxide nanozyme-I (Vnps-I) containing a high valence of vanadium (V5+) has catalase (CAT) activity, which can catalyze hydrogen peroxide (H2O2) into oxygen (O2), which is beneficial to alleviate the hypoxic environment of solid tumors. Finally, a vanadium oxide nanozyme with both trienzyme simulation activity and GSH consumption ability was screened out by adjusting the ratio of V4+ to V5+ in vanadium oxide nanozymes. In cell and animal experiments, we successfully demonstrate that vanadium oxide nanozymes have excellent antitumor ability and high safety, which may bring great potential for clinical cancer treatment.

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“…During the treatment with PTT, the heat‐treated cancer cells may generate heat resistance due to the increase of heat shock protein (HSP) level, reducing the effectiveness of treatment. [ 122‐124 ] The combined application of photothermal materials and HSP inhibitors to inhibit the function of HSP was considered to be an effective way to improve the efficiency of PTT in tumor treatment. [ 125‐126 ] We use the photothermal properties of silver sulfide to design a nano‐therapeutic reagent, namely QE‐PEG‐Ag 2 S , loaded with a pH responsive polymer and heat shock protein inhibitor (Figure 14).…”

Section: Activated Theranostics Platform Integrating Diagnosis and Tr...mentioning

confidence: 99%

From Fluorescent Probes to the Theranostics Platform

Wei

Wang

2022

Chin. J. Chem.

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What is the most favorite and original chemistry developed in your research group?Development of new responsive fluorescent molecules and using them as tools to study physiological and pathological processes of specific biomolecules. How do you get into this specific field?My original major is inorganic chemistry. Influenced by Prof. Chunhui Huang (academician), I was interested in fluorescent materials. The flowery color of fluorescent material itself and its important applications in the field of biological probes and imaging are also touched me deeply. What are your hobbies? Reading and travelling.

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Green synthesis of ultra-small VOx nanodots for acidic-activated HSP60 inhibition and therapeutic enhancement

Cited by 22 publications

References 41 publications

Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

Natural Polyphenol–Vanadium Oxide Nanozymes for Synergistic Chemodynamic/Photothermal Therapy

Vanadium Oxide Nanozymes with Multiple Enzyme-Mimic Activities for Tumor Catalytic Therapy

From Fluorescent Probes to the Theranostics Platform

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