Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination in vivo

Abstract

Prussian blue-modified upconversion nanoprobes are applicable for highly selective H2S imaging and elimination in vivo.

Simultaneous multi-signal quantification for highly precise serodiagnosis utilizing a rationally constructed platform

“…Then, its quantification performance was tested in biological C H2S range, which was from nanomolar to micromolar level according to our previous findings 6 . The changes in current (ΔI), the natural logarithm value of luminescence ratio (Ln[I 654 /I 1550 ]), and Ln[I 525 /I 545 ] correlated linearly with C H2S .…”

“…Therefore, the evaluation of plasma H 2 S concentrations may be useful in the serodiagnosis of AP. A variety of single-signal methods for AP serodiagnosis have recently been demonstrated, which are performed efficiently in AP 4–6 . However, it has been noted that, when only one signal is used to evaluate the plasma H 2 S concentration, it is strongly influenced by the biological environment and operating conditions, which may result in elevated false-positive or -negative results and reduce the precision of the serodiagnosis.…”

Rational synthesis of three-dimensional core–double shell upconversion nanodendrites with ultrabright luminescence for bioimaging application

“…This implies that less excitation light can reach the inner cores and less emission light can pass out as reported elsewhere. 8,[42][43][44][45] However, the maximum UCLE of UCND@SiO 2 -COOH silica is comparable with that of the hydrophobic UCNP core-shell in cyclohexane (Fig. 6a) and hydrophobic NaYF 4 :Yb 3+ ,Er 3+ @NaGdF 4 UCNPs in cyclohexane (Fig.…”

“…Rare-earth Yb 3+ and Er 3+ doped NaYF 4 -based UCNPs are highly promising in bioimaging applications owing to their low phonon energies, inferior autouorescence background, deep penetration lengths, high brightness, excellent stabilities, and nonblinking emissions. [1][2][3][4][5][6][7][8][9][10] These merits depend on the size, morphology, and composition of NaYF 4 :Yb 3+ /Er 3+ UCNPs. 11,12 For example, the UCLE intensity of NaYF 4 :Yb 3+ /Er 3+ /Tm 3+ nanoplates was signicantly superior to that of its counterparts such as nanospheres, nanoellipses and nanoprisms.…”

H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

“…Therefore, precise spatiotemporal detection of H 2 S in living subjects is essential to the study of the biological functions and accurate diagnosis of H 2 Srelated diseases. Although numerous H 2 S-activatable fluorescent probes have been developed, the insufficient reaction kinetics, poor in vivo targeting ability, and limited tissue penetration of fluorescence have restricted the capacity to detect H 2 S' concentrations and locations in living animals [40][41][42][43][44][45][46] . Recently, we reported the engineering of an organic π-electron structure-based electrochromic material (EM 1 2+ ) as an H 2 S-responsive chromophore, which was amenable to build H 2 S-activatable NIR fluorescent probes for noninvasive imaging of H 2 S in living mice 47 .…”