A power-efficient frequency compensation topology, Impedance Adapting Compensation (IAC), is presented in this paper. This IAC topology has, on one hand, a normal Miller capacitor, which is still needed to provide an internal negative feedback loop, and on the other hand, a serial RC impedance as a load to the intermediate stage, improving performance parameters such as stability, gain-bandwidth product and power dissipation.A three-stage IAC amplifier was implemented and fabricated in a 0.35 m CMOS technology. Experiment results show that the implemented IAC amplifier, driving a 150 pF load capacitance, achieved a gain-bandwidth product (GBW) of 4.4 MHz while dissipating only 30 W power with a 1.5 V supply.
The Network-on-Chip (NoC) has been recognized as a paradigm to solve System-on-Chip (SoC) design challenges. The routing algorithm is one of key researches of a NoC design. XY routing algorithm, which is a kind of distributed deterministic routing algorithms, is simple to be implemented. Odd-Even (OE) routing algorithm, whose implementation is complex, is a sort of distributed adaptive routing algorithms with deadlock-free ability. We demonstrate the two routing algorithms in details at first. XY routing algorithm and OE routing algorithm are then simulated and compared based on a 3X3 mesh topology NoC with NIRGAM simulator. The simulation results show that OE routing algorithm, whose P parameter equals to 1.09, increases P parameter greatly as compared to XY routing algorithm, whose P parameter equals to 0.86, in a 2-dimension 3X3 mesh topology NoC, with Constant Bit Rate (CBR) traffic condition of each tail.
Bronchopulmonary dysplasia (BPD) is the most common complication of extremely preterm birth. This study was aimed at detecting cytokine and fractional exhaled nitric oxide (FeNO) levels to evaluate their mechanisms and predicted significance for BPD. Preterm infants born at
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≤
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were recruited, and clinical data were collected. We detected ten cytokines, including IFN-γ, IL-10, IL-12p70, IL-13, IL-1β, IL-2, IL-4, IL-6, IL-8, and TNF-α on Days 1–3, Days 7–14, and Days 21–28 after birth by using the Meso Scale Discovery (MSD) technology. The FeNO levels of infants were measured when they met the discharge criteria. A total of 46 preterm infants were enrolled, consisting of 14 infants in BPD group and 32 infants in the control group. The gestational age (
27.5
±
1.3
vs.
29.9
±
1.3
weeks) and birth weight (
1021
±
261
g vs. 1489 ± 357 g) were lower in the BPD group. The following were high-risk factors for BPD, as determined by multivariate logistic regression analysis:
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g
, PDA, longer mechanical ventilation, and higher FeNO. The cytokines of IL-6 and IL-8 on Days 7–14 and IL-4, IL-6, IL-8, and TNF-α on Days 21–28 were also high-risk factors for BPD. IL-6 contributed to BPD disease severity. Conclusion. The preterm infants with PDA and prolonged mechanical ventilation tended to develop BPD. The IL-6 and IL-8 were significantly increased on Days 7–14 and were high-risk factors for BPD. Moreover, the IL-6 level was associated with BPD disease severity. We speculated that NO was related to BPD via Th2 cell-mediated inflammatory responses such as IL-4 and IL-6. Cytokines might predict the occurrence of BPD.
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