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Biologists and engineers are making tremendous efforts in contributing to a sustainable and green society. To this end, there is an increase in interest towards waste management cum valorisation. Lignocellulosic...

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2,3-Butanediol (BDO) is a versatile platform chemical with great potential as the precursor for various valueadded derivatives across different industrial sectors. This work thus presents a techno-economic feasibility study for microbial BDO production from C 5 and C 6 sugars derived from brewers' spent grain (BSG). Water-soluble carbohydrates obtained from pretreatment were further utilized for the biogas generation. Besides, the solid residue generated after fermentation and biogas were used to generate high-pressure steam and electricity. The process integration was carried out using pinch technology for various BDO titers and plant capacities. The pinch analysis helped in the reduction of hot and cold utility consumption by about 34 and 18%, respectively. The minimum hot and cold utility consumption was 4.59 and 10.97 MW for 100 MT BSG per day with 100 g/L BDO titer, respectively. The cooling water consumption was decreased, and electricity generation was increased with the increase in BDO titer, while the BDO production cost reduced marginally.