We report our observations on day-to-day variation in serum ferritin, serum iron, total iron-binding capacity, and percent saturation of binding proteins with iron in 13 ostensibly healthy subjects during five weeks. The average intrasubject coefficients of variation were 14.5, 28.5, 4.8, and 28.0%, respectively. Precision studies on control samples showed greater within-assay and between-assay analytical variation for serum ferritin than for serum iron or total iron-binding capacity. Evidently, serum ferritin varies less in a given individual from day to day than do serum iron and percent iron saturation. Thus, a single measurement of serum ferritin may be a more reliable index of iron stores than an isolated determination of either serum iron or percent iron saturation.
This report describes the case of a patient with a mesenteric lymphoid mass with clinical and histologic features suggestive of giant lymph node hyperplasia (GLH) who died as a result of complications related to systemic amyloidosis. To our knowledge, this is only the second case of amyloidosis associated with a benign mesenteric lymphoid mass reported in the literature. The possible relationship of amyloid with GLH will be discussed.
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