Lung abscess due to corynebacterium equi. Report of the first case in a patient with acquired immune deficiency syndrome

Samies, John; Hathaway, Bruce N.; Echols, Roger; Veazey, James M.; Pilon, Vernon A.

doi:10.1016/0002-9343(86)90825-9

Cited by 99 publications

(48 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Frequent severe reactions to this class of antimicrobial agents have been described, in particular, for HIV-infected patients (214). Drug therapy for R equi infections in HIV-infected patients may also be complicated by the development of acquired resistance to beta-lactam antimicrobial agents (437,500,631).…”

Section: Laboratory Diagnosismentioning

confidence: 99%

“…However, despite its in vitro susceptibility to various antimicrobial agents, R. equi is difficult to eradicate even after prolonged therapy (172,309,363,500,613,631). Thus, relapses are frequently observed and may occur even after surgical resection of the affected lung segments (57,236,500). Several measures are important in the effective therapy of infected patients.…”

Section: Laboratory Diagnosismentioning

confidence: 99%

See 1 more Smart Citation

The medically important aerobic actinomycetes: epidemiology and microbiology

1994

View full text Add to dashboard Cite

The aerobic actinomycetes are soil-inhabiting microorganisms that occur worldwide. In 1888, Nocard first recognized the pathogenic potential of this group of microorganisms. Since then, several aerobic actinomycetes have been a major source of interest for the commercial drug industry and have proved to be extremely useful microorganisms for producing novel antimicrobial agents. They have also been well known as potential veterinary pathogens affecting many different animal species. The medically important aerobic actinomycetes may cause significant morbidity and mortality, in particular in highly susceptible severely immunocompromised patients, including transplant recipients and patients infected with human immunodeficiency virus. However, the diagnosis of these infections may be difficult, and effective antimicrobial therapy may be complicated by antimicrobial resistance. The taxonomy of these microorganisms has been problematic. In recent revisions of their classification, new pathogenic species have been recognized. The development of additional and more reliable diagnostic tests and of a standardized method for antimicrobial susceptibility testing and the application of molecular techniques for the diagnosis and subtyping of these microorganisms are needed to better diagnose and treat infected patients and to identify effective control measures for these unusual pathogens. We review the epidemiology and microbiology of the major medically important aerobic actinomycetes.

show abstract

Section: Laboratory Diagnosismentioning

confidence: 99%

Section: Laboratory Diagnosismentioning

confidence: 99%

The medically important aerobic actinomycetes: epidemiology and microbiology

1994

View full text Add to dashboard Cite

show abstract

“…Use of this combination has considerably reduced foal mortality due to R. equi infection (74,159). These drugs have also been used alone or in combination, usually with good clinical response, in many human infections (73,85,90,121,146,147). Although the combina- tion of gentamicin with penicillin gave additive and sometimes synergistic activity in vitro (130), in one study, use of this combination to treat foals with R. equi pneumonia was invariably associated with their death (74), possibly because penetration of macrophages or neutrophils by these drugs is so poor.…”

Section: Diagnostic Proceduresmentioning

confidence: 99%

Rhodococcus equi: an animal and human pathogen

1991

View full text Add to dashboard Cite

Recent isolations of Rhodococcus equi from cavitatory pulmonary disease in patients with AIDS have aroused interest among medical microbiologists in this unusual organism. Earlier isolations from humans had also been in immunosuppressed patients following hemolymphatic tumors or renal transplantation. This organism has been recognized for many years as a cause of a serious pyogranulomatous pneumonia of young foals and is occasionally isolated from granulomatous lesions in several other species, in some cases following immunosuppression. The last decade has seen many advances in understanding of the epidemiology, pathogenesis, diagnosis, treatment, and immunity to infection in foals. The particular susceptibility of the foal is not understood but can be explained in part by a combination of heavy challenge through the respiratory route coinciding with declining maternally derived antibody in the absence of fully competent foal cellular immune mechanisms. R. equi is largely a soil organism but is widespread in the feces of herbivores. Its growth in soil is considerably improved by simple nutrients it obtains from herbivore manure. About one-third of human patients who have developed R. equi infections had contact in some way with herbivores or their manure. Others may have acquired infection from contact with soil or wild bird manure. R. equi is an intracellular parasite, which explains the typical pyogranulomatous nature of R. equi infections, the predisposition to infection in human patients with defective cell-mediated immune mechanisms, and the efficacy of antimicrobial drugs that penetrate phagocytic cells.

show abstract

“…Recently, R. equi has been identified increasingly as an invasive pulmonary and potentially life-threatening, opportunistic pathogen in immunocompromised patients, in particular, HIV-infected patients (3,4,6,8,12,13,27). Primary pulmonary R. equi infections have been reported most frequently in AIDS patients, and the likely route of transmission in these patients is via inhalation of the bacteria from the environment (3,12).…”

mentioning

confidence: 99%

Expression of Virulence‐Associated Antigens of Rhodococcus equi Is Regulated by Temperature and pH

Takaı̈

Fukunaga

Kamisawa

et al. 1996

Microbiology and Immunology

View full text Add to dashboard Cite

in this study. Expression of these two virulence-associated antigens of R. equi was regulated by pH and temperature; the antigens were produced maximally when the isolates were grown at 38 C and pH 6.5, but were not produced when grown at 38 C and pH 8, nor at temperatures below 30 C. The 20-kDa antigen was found to be located on the cell surface, as were the 15-to 17-kDa antigens, and showed susceptibility to proteolysis by trypsin. These results indicate that expression of the virulence-associated antigens of R. equi is dependent on the environmental conditions.

show abstract

Lung abscess due to corynebacterium equi. Report of the first case in a patient with acquired immune deficiency syndrome

Cited by 99 publications

References 12 publications

The medically important aerobic actinomycetes: epidemiology and microbiology

The medically important aerobic actinomycetes: epidemiology and microbiology

Rhodococcus equi: an animal and human pathogen

Expression of Virulence‐Associated Antigens of Rhodococcus equi Is Regulated by Temperature and pH

Contact Info

Product

Resources

About