Day-to-day variation in serum ferritin concentration in healthy subjects.

Pilon, Vernon A.; Howanitz, Peter J.; Howanitz, Joan H.; Domres, N

doi:10.1093/clinchem/27.1.78

Cited by 64 publications

(19 citation statements)

References 18 publications

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“…The difference was found to be considerably greater than the expected variations from one day to another in normal individuals (12).…”

Section: Results A) Serum Ferritinmentioning

confidence: 53%

Changes in serum ferritin following surgical trauma

Zdravkovic¹

1987

European J of Haematology

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A statistically significant increase in serum ferritin values was found in 14 male patients already 1 d after uniform operative trauma and, on the 3rd d following operation, the last day of observation period values were still increased. Moreover, in all patients a highly significant fall in plasma iron of acute onset was found. The hypoferremia was already seen on the day after operation. Serum transferrin was also found to be significantly reduced after operation.

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“…The difference was found to be considerably greater than the expected variations from one day to another in normal individuals (12).…”

Section: Results A) Serum Ferritinmentioning

confidence: 53%

Changes in serum ferritin following surgical trauma

Zdravkovic¹

1987

European J of Haematology

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“…When evaluating serum tests for iron status, it is important to remember that the tests are subject to preanalytical, analytical, and within-individual biologic variability [Witte et al, 1996]. The time of day, the recent ingestion of a meal, and regular consumption of iron-containing supplements can all influence the measurement of iron analytes in serum [Henry, 2001;Pilon et al, 1981;Ritchie et al, 2002;Witte et al, 1996]. The values are influenced by the physiological status of the animal as well.…”

Section: Discussionmentioning

confidence: 99%

Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs

Williams

Campbell

Glenn

2006

American J Primatol

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Lemurs kept in captivity have been reported to be highly prone to accumulate excessive amounts of iron in tissues (hemosiderosis). Diagnosis of the condition is most commonly made during a postmortem examination because an antemortem diagnosis requires a liver biopsy, a procedure that may not be well tolerated by all animals. The lack of a noninvasive method to evaluate iron status in captive lemurs limits investigators' ability to effectively screen animals for the presence of hemosiderosis, and to detect the condition early when treatment protocols are most effective. This study was conducted in an effort to provide data regarding iron analyte values in healthy captive lemurs of multiple species. The relationship of various iron-related metabolites was evaluated in 177 clinically normal lemurs of nine different species. Serum iron (sI), total iron binding capacity (TIBC), and ferritin concentration were measured directly and the percent transferrin saturation (TS) was calculated. Significant differences in various iron metabolites were observed among several species, suggesting that normal reference values for iron metabolites in lemurs may need to be developed on a species by species basis.

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“…Changes in serum ferritin concentration have been used as a means to estimate changes in iron stores (12,16), although the exact relation of serum ferritin to mobilizable iron is uncertain (17), especially after iron therapy for iron-deficiency anemia. Serum ferritin concentrations may be increased by inflammatory conditions and even in normal individuals, in a steady state, physiologic variations result in a mean coefficient of variation of 15% or more from day to day or week to week (19,20). Recognizing these limitations in the accuracy of our estimate, we used the changes in serum ferritin in the study group to estimate changes in iron stores and permit an overall comparison of the changes in total body iron with the two treatments.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability of carbonyl iron: A randomized, double‐blind study

Devasthali

Gordeuk

Brittenham

et al. 1991

European J of Haematology

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49 female blood donors with iron‐deficiency anemia were treated with equal doses of iron either as carbonyl iron or ferrous sulfate in a randomized, double‐blind fashion. The prevalence of side‐effects was similar in the two groups. Mean values for hemoglobin concentration, mean corpuscular volume, corrected reticulocyte count, platelet count, serum iron, total iron‐binding capacity, transferrin saturation or erythrocyte proto‐porphyrin did not differ significantly between the two groups throughout the study. After 16 weeks of therapy, the mean increase in hemoglobin iron was similar in both groups (p = 0.2). Estimates of net changes in total body iron suggested that the overall bioavailability of carbonyl iron was high, about 70% that of ferrous sulfate.

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Day-to-day variation in serum ferritin concentration in healthy subjects.

Cited by 64 publications

References 18 publications

Changes in serum ferritin following surgical trauma

Changes in serum ferritin following surgical trauma

Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs

Bioavailability of carbonyl iron: A randomized, double‐blind study

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