Changes in serum ferritin following surgical trauma

Zdravkovic, D

doi:10.1111/j.1600-0609.1987.tb01425.x

Cited by 10 publications

(4 citation statements)

References 15 publications

(7 reference statements)

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“…The observed low transferrin concentrations are in agreement with other studies in trauma or other critically ill patients [ 6 , 36 , 37 ], whereas reports on ferritin levels are more variable. Although we observed ferritin levels in the burn patients to be in the normal range and then increase above normal by day 14, others have reported elevated ferritin early after acute injury, surgery or illness in both experimental animals and humans [ 36 , 37 , 38 , 39 ]. Efforts to understand the ferritin response to injury have focused on development of some form of acute lung injury.…”

Section: Discussioncontrasting

confidence: 75%

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

et al. 2015

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Objective: Normal iron handling appears to be disrupted in critically ill patients leading to hypoferremia that may contribute to systemic inflammation. Ceruloplasmin (Cp), an acute phase reactant protein that can convert ferrous iron to its less reactive ferric form facilitating binding to ferritin, has ferroxidase activity that is important to iron handling. Genetic absence of Cp decreases iron export resulting in iron accumulation in many organs. The objective of this study was to characterize iron metabolism and Cp activity in burn and non-burn trauma patients to determine if changes in Cp activity are a potential contributor to the observed hypoferremia. Material and Methods: Under Brooke Army Medical Center Institutional Review Board approved protocols, serum or plasma was collected from burn and non-burn trauma patients on admission to the ICU and at times up to 14 days and measured for indices of iron status, Cp protein and oxidase activity and cytokines. Results: Burn patients showed evidence of anemia and normal or elevated ferritin levels. Plasma Cp oxidase activity in burn and trauma patients were markedly lower than controls on admission and increased to control levels by day 3, particularly in burn patients. Plasma cytokines were elevated throughout the 14 days study along with evidence of an oxidative stress. No significant differences in soluble transferrin receptor were noted among groups on admission, but levels in burn patients were lower than controls for the first 5 days after injury. Conclusion: This study further established the hypoferremia and inflammation associated with burns and trauma. To our knowledge, this is the first study to show an early decrease in Cp oxidase activity in burn and non-burn trauma patients. The results support the hypothesis that transient loss of Cp activity contributes to hypoferremia and inflammation. Further studies are warranted to determine if decreased Cp activity increases the risk of iron-induced injury following therapeutic interventions such as transfusions with blood that has undergone prolonged storage in trauma resuscitation.

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Section: Discussioncontrasting

confidence: 75%

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

et al. 2015

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“…The acute-phase response of systemic inflammation due to cardiopulmonary bypass includes a fall in total iron-binding capacity and transferrin that has been attributed to extravasations of these proteins [23]. A pattern of iron overload (bypass related haemolysis, mobilization of tissue iron into the vascular compartment after ischemia, and cardiomyocyte necrosis liberating myoglobin and other intracellular proteins containing iron) superimposed on this acute-phase response result in increase in availability of free iron which acts as catalyst for free radical production [24] [25]. The decrease in TIBC along with increase in serum iron results increase in availability of free iron even though mean levels of serum iron approached high normal values in our study.…”

Section: Biochemical Indicator Of Rv Dysfunctionmentioning

confidence: 99%

“…The decrease in TIBC along with increase in serum iron results increase in availability of free iron even though mean levels of serum iron approached high normal values in our study. Ferritin is acute phase reactant protein, whose levels increases during inflammation [26]. The uniform inflammatory response to stress of cardiopulmonary bypass may explain significant rise of ferritin in both the groups despite iron overloading in patient with RV dysfunction only.…”

Section: Biochemical Indicator Of Rv Dysfunctionmentioning

confidence: 99%

Assessment of Right Ventricular Function in Post Operative Patients of Tetralogy of Fallots and Its Predictive Factors

Singh¹,

Kalra²,

Kumar³

et al. 2014

WJCS

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Introduction: Right ventricular (RV) dysfunction can occur early and late in patients after intracardiac repair (ICR) for Tetralogy of Fallots (TOF). This study focuses on early RV dysfunction as there is limited data on it. Aims & Objective: RV function was studied with respect to its incidence, course over 3 months, co-relation with peri operative factors and serum iron levels. Material & Method: All patients of TOF undergoing ICR during July 2007-October 2008, done by single surgeon at a single centre, were prospectively studied. Patients were divided into group A (with RV dysfunction) and group B (without RV dysfunction). All patients underwent pre operative & post operative clinical assessment, biochemical evaluation (serum iron profile & CK MB) and 2D echocardiography (pulse Doppler & tissue Doppler). Echocardiography was done at 24 hours, 4 weeks & 12 weeks of ICR. Patients were also assessed for intra operative parameters including cross clamp time, by pass time, acidosis, RV and PA pressures. Results: 24 patients underwent ICR (transannular patch repair) with mean age of 7.31 ± 4.74 years. RV dysfunction was present in 13 patients (54.2%) but was persistent only in 15.3% (2/13) at 12 weeks. Presence of cyanotic spell (p = 0.006), recurrent chest infection (p = 0.002), raised heamatocrit (p = 0.02), and rise in serum iron level (p = 0.002) were significantly associated with post operative RV dysfunction. It resulted in prolong ICU stay and slower recovery. Pre operative RV dysfunction was associated with diffi-* Corresponding author. cult weaning from bypass and poor post operative outcome (p < 0.001). Conclusion: RV dysfunction is commonly present even after satisfactory ICR. Its aetiology remains unclear in such setting. In our study, pre operative clinical profile and serum iron fluctuations were important determinants of post operative outcome.

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“…Από τη βιβλιογραφία καταγράφησαν οι προβληματισμοί και οι δυσκολίες της έγκαιρης διάγνωσης και αντιμετώπισης της οστικής λοίμωξης. 1474 9394 η επιλογή της Φερριτίνης ορού ως συμπληρωματικού δείκτη παρακολούθησης της οστικής λοίμωξης έγινε με βάση το ρόλο της ως πρωτεΐνη οξείας φάσης 15,178 1 9 232 αλΛά και της βιβλιογραφικές ενδείξεις που συνδέουν τις μεταβολές των επιπέδων της με την -r-m1/ττ ςΐ\ ,ς" ιΛ; ς 19,21,24,62,97,107,211,231 παρουσία και εξελιξη της λοίμωξης. Ο σχεδιασμός της μελέτης περιέλαβε ομάδες ασθενών με κατάγματα τα οποία αντιμετωπίστηκαν χειρουργικά (ομάδα-1: «κάταγμα + χειρουργική επέμβαση») ή συντηρητικά (ομάδα-3: «κάταγμα») και ομάδα ασθενών που υπεβλήθησαν σε χειρουργική επέμβαση για χρόνια ορθοπαιδική πάθηση (ομάδα-2: «χειρουργική επέμβαση»).…”

Section: συζητησηunclassified

Ο Ρόλος Της Φερριτίνης Ορού Ως Προγνωστικός Και Διαγνωστικός Δείκτης Των Ορθοπαιδικών Λοιμώξεων

Τριανταφυλλόπουλος¹

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Περιγραφική στατιστική (Πίνακες, Διαγράμματα) 7.1.2 Σύγκριση των απόλυτων τιμών των μεταβλητών στο baseline ανάμεσα στις ομάδες μελέτης. 7.1.3 Διαχρονική μεταβολή των τιμών των μεταβλητών ανά ομάδα μελέτης. 7.1.4 Σύγκριση των ποσοστιαίων μεταβολών από το baseline των μεταβλητών ανάμεσα στις ομάδες. 7.1.5 Συγκρίσεις της AUC κατά τη διάρκεια της παρακολούθησης ανάμεσα στις ομάδες μελέτης. 7.1.6 Συσχέτιση της ποσοστιαίας μεταβολής της Φερριτίνης ορού με τις λοιπές μεταβλητές ανά χρονική στιγμή. 7.1.7 Συσχέτιση της Φερριτίνης ορού με τις λοιπές μεταβλητές ανά χρονική στιγμή χρησιμοποιώντας το μοντέλο ανάλυσης διακύμανσης δύο παραγόντων με επαναληπτικές μετρήσεις 7.2 ΕΝΔΕΙΞΕΙΣ ΤΟΥ ΔΙΑΓΝΩΣΤΙΚΟΥ ΡΟΛΟΥ ΤΗΣ ΦΕΡΡΙΤΙΝΗΣ ΟΡΟΥ 7.2.1 Μελέτη της διαχρονικής μεταβολής των μεταβλητών ανάμεσα στις ομάδες μελέτης. 7.3 ΕΝΔΕΙΞΕΙΣ ΤΟΥ ΠΡΟΓΝΩΣΤΙΚΟΥ ΡΟΛΟΥ ΤΗΣ ΦΕΡΡΙΤΙΝΗΣ ΟΡΟΥ 7.3.1 Περιγραφική στατιστική (Πίνακες, Διαγράμματα) 7.3.2 Σύγκριση των απόλυτων τιμών των μεταβλητών στο baseline ανάμεσα στις ομάδες μελέτης. 7.3.3 Διαχρονική μεταβολή των τιμών των μεταβλητών ανά ομάδα μελέτης. 7.3.4 Συγκρίσεις των ποσοστιαίων μεταβολών από το baseline των μεταβλητών ανάμεσα στις ομάδες. 7.3.5 Συγκρίσεις της AUC κατά τη διάρκεια της παρακολούθησης ανάμεσα στις ομάδες μελέτης. 7.3.6 Συσχέτιση της ποσοστιαίας μεταβολής της Φερριτίνης ορού με τις λοιπές μεταβλητές σε κάθε χρονική στιγμή. 7.3.7 Συσχέτιση της Φερριτίνης με τις μεταβλητές ΤΚΕ και CRP ανά χρονική στιγμή εφαρμόζοντας το μοντέλο ανάλυσης διακύμανσης 2 παραγόντων με επαναληπτικές μετρήσεις. 7.3.8 ROC ανάλυση των ποσοστιαίων μεταβολών των μεταβλητών διαχρονικά. 7.3.9 Χρονική συσχέτιση της αύξησης της Φερριτίνης ορού και της κλινικής εκδήλωσης της λοίμωξης.

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Changes in serum ferritin following surgical trauma

Cited by 10 publications

References 15 publications

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

Ceruloplasmin and Hypoferremia: Studies in Burn and Non-Burn Trauma Patients

Assessment of Right Ventricular Function in Post Operative Patients of Tetralogy of Fallots and Its Predictive Factors

Ο Ρόλος Της Φερριτίνης Ορού Ως Προγνωστικός Και Διαγνωστικός Δείκτης Των Ορθοπαιδικών Λοιμώξεων

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