Malignant osteoclast-like giant cell tumor associated with a uterine leiomyosarcoma

Pilon, Vernon A.; Parikh, Nita; Maccera, Jose

doi:10.1016/0090-8258(86)90142-3

Cited by 32 publications

(27 citation statements)

References 17 publications

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“…We found reports of 9 other cases of GCT of the uterus [45][46][47][48][49][50][51]. Three patients in whom follow up was available died of their tumors.…”

Section: Resultsmentioning

confidence: 78%

Giant cell tumor of the uterus: case report and response to chemotherapy

Skubitz

Manivel

2007

BMC Cancer

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Background: Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor. The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors. Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined.

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“…We found reports of 9 other cases of GCT of the uterus [45][46][47][48][49][50][51]. Three patients in whom follow up was available died of their tumors.…”

Section: Resultsmentioning

confidence: 78%

Giant cell tumor of the uterus: case report and response to chemotherapy

Skubitz

Manivel

2007

BMC Cancer

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“…Many investigators have favoured a histiocyte/monocyte origin due in part to the frequent presence of OGCT in areas of haemorrhage or necrosis (Pilon et al, 1986;Molinie et al, 1997;Masui et al, 1998). In our case, immunoperoxidase stains were performed in an attempt to define the nature of OGCT cells, i.e.…”

Section: Discussionmentioning

confidence: 99%

“…In humans, OGCT has been diagnosed in visceral organs including the kidney (Borg-Grech et al, 1987;Molinie et al, 1997;Heller et al, 1998), uterus (Pilon et al, 1986) and pancreas (Dworak et al, 1993) in addition to the abovementioned tissues. There are six reported cases of OGCT involving the kidney of humans.…”

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confidence: 99%

“…Osteoclast-like giant cell tumour (OGCT) is a rare extraskeletal tumour of humans and animals, somewhat resembling the giant cell tumour of bone (Guccion and Enzinger, 1972;Ford et al, 1975;Pilon et al, 1986;Molinie et al, 1997;Masui et al, 1998). Histopathologically, it consists of a mixture of multinucleated giant cells, spindle-spheroidal cells and oedematous and vascular fibrous stroma (Ford et al, 1975;Hamir, 1989).…”

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confidence: 99%

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Osteoclast-like giant cell tumour arising from the kidney in a dog

Haziroğlu

Kul

Tunca

et al. 2005

Acta Veterinaria Hungarica

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In this study, a case of osteoclast-like giant cell tumour arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26 × 22 × 12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell tumour arising from a visceral organ in animals.

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“…However leiomyosarco ma with osteoclast-like giant cells is a rare tumor which mimics the giant cell variant of malignant fibrous histio cytoma (MFH). Very few cases of this tumor have been described, mainly in the uterus and soft tissues of the extremities [1][2][3][4][5][6]. We describe an additional case of this tumor arising from the spermatic cord and involving the testis.…”

Section: Introductionmentioning

confidence: 96%

Leiomyosarcoma with Osteoclast-Like Giant Cells of the Spermatic Cord

et al. 1996

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We describe a case of leiomyosarcoma with osteoclast-like giant cells arising form the spermatic cord and involving the testis. This is a rare tumor which is histologically similar to the giant cell variant of malignant fibrous histiocytoma. No such cases have been reported arising from the external genitalia. The patient was initially treated with local excision. He had a local recurrence 7 years later which was treated with radical excision and adjuvant radiation. The indolent nature of the tumor, with a long survival of 7 years after initial diagnosis followed subsequently by a more aggressive clinical course, is emphasized.

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Malignant osteoclast-like giant cell tumor associated with a uterine leiomyosarcoma

Cited by 32 publications

References 17 publications

Giant cell tumor of the uterus: case report and response to chemotherapy

Giant cell tumor of the uterus: case report and response to chemotherapy

Osteoclast-like giant cell tumour arising from the kidney in a dog

Leiomyosarcoma with Osteoclast-Like Giant Cells of the Spermatic Cord

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