Osteoclast-like giant cell tumour arising from the kidney in a dog

Abstract

In this study, a case of osteoclast-like giant cell tumour arising from the kidney is reported in an eight-year-old female Anatolian Shepherd dog. Macroscopically, the tumorous mass covered the hilus of the left kidney. It was 26 × 22 × 12 cm in size and 3700 g in weight. Metastatic tumorous nodules, 0.5-2.0 cm in diameter, were found on the abdominal side of the diaphragm and in the lungs. Microscopically, numerous large osteoclast-like multinucleated giant cells and spindle-spheroidal-shaped cells were seen. Osteoblastic differentiation and osteoid matrix were noted in a few areas at the periphery of the tumour, near the connective tissue septa. The stroma of the tumour tissue was vascular, oedematous and loose. By immunoperoxidase staining, tumour cells showed immunoreactivity for vimentin but not for keratin and desmin, indicating that the tumour had mesenchymal origin. This is the first report in the literature on a malignant osteoclast-like giant cell tumour arising from a visceral organ in animals.

Primary Renal Neoplasia of Dogs

“…Previous reports have examined primarily carcinomas with only a series of 6 sarcomas and case reports of a spindle cell sarcoma, osteosarcoma, leiomyosarcoma, hemangioma, hemangiosarcoma, giant cell tumor, oncoctyoma, and mixed mesenchymal tumor in the literature. 2,4,[8][9][10][11][12][13][14][15][16] Twenty-seven of the dogs presented here were renal cell carcinomas or a tubular, tubular and papillary, or clear cell variant of renal carcinoma. Twelve had more differentiated tumors classified as adenocarcinomas.…”

Primary renal fibrosarcoma with local invasion into the mesenteric membrane of a mongrel dog

“…Previous reports found that the incidence of primary renal neoplasm accounts for 0.3% to 1.5% of all canine neoplasms [1,13]. Few cases of renal sarcomas, including spindle cell sarcomas, leiomyosarcoma, osteosarcoma, hemangioma, hemangiosarcoma, fibrosarcoma, oncocytoma, and giant cell tumors, are reported [1,2,8,12,13]. In humans, primary renal sarcomas contribute to only 1% to 3% of all renal tumors [3,7].…”