Renal Neoplasia

Henry, Carolyn J.

doi:10.1002/9781118785546.ch57

Cited by 1 publication

(2 citation statements)

References 31 publications

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“…These nodules are normally locally invasive and can metastasize to the lungs and other sites 43 . The feline sarcoma virus (FeSV) is a recombinant version of the FeLV, where the recombination of the FeLV genome with cellular oncogenes of the infected cat causes uncontrolled cell proliferation 43,44 . Through this recombination, FeSV can acquire one of the multiple oncogenes including FES, FMS, or FGR 43 .…”

Section: Soft Tissue Sarcomamentioning

confidence: 99%

“…Through this recombination, FeSV can acquire one of the multiple oncogenes including FES, FMS, or FGR 43 . Oncogenes associated with FeSV were discovered by transforming fibroblasts and producing a fibrosarcoma that is multicentric in younger cats 43,44 . Older studies show that only about 2% of the fibrosarcomas found in cats are virally induced and as cases of FeLV have decreased so have cases of FeSV [43][44][45] .…”

Section: Soft Tissue Sarcomamentioning

confidence: 99%

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Characterization of the genetic landscape of feline oral squamous cell carcinoma

Rodney¹

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Over 94 million domestic cats are susceptible to cancers and other common and rare diseases. While cancer treatment in cats increasingly mirrors that available in humans, treatment failures are more frequent. There are no FDA or USDA approved cancer drugs for cats and a paucity of cancer treatments beyond surgery, radiotherapy, and cytotoxic chemotherapy indicate an urgent need to define the molecular properties of aggressive feline cancers including common cancers such as soft tissue sarcoma, mammary carcinoma, lymphoma, and feline oral squamous cell carcinoma. Whole exome sequencing (WES) is a proven strategy to study these disease-causing variants in humans and other organisms. To examine the effectiveness of WES in the study of feline cancer and Mendelian diseases, whole exome sequencing was conducted on 41 cats with known and unknown genetic diseases and traits, of which ten cats had matching whole genome sequence (WGS) data available, used to validate WES performance. Within the 41 cats, we identified 31 previously known causal variants and discovered new gene candidate variants, including novel missense variance for polycystic kidney disease and atrichia in the Peterbald cat. The WES data was sufficient to identify novel gene candidate alleles for diseases and traits in a feline model. Feline oral squamous cell carcinoma (FOSCC) is a cancer of the squamous cell lining in the oral cavity and represents up to 80 percent of all oral cancers in cats, with a low one-year survival rate of <10 percent. The cancer pathology associated with feline oral squamous cell carcinoma is similar to human head and neck squamous cell carcinoma (HNSCC), which accounts for 90 percent of oral cancers in humans. FOSCC may present as a potential model to study HNSCC due to spontaneous formation, similar genetic landscape, pathology, and survival rates. We have generated single nucleotide variant calls using GATK-Mutect2 on six cats with FOSCC and have fully annotated and identified driver genes in common with HNSCC. Due to low sample size, a larger cohort is needed to draw stronger association of disease-causing traits. Our results show some overlap in the genetic landscape of both cancers, with five samples have mutations in p53, a common mutation in HNSCC, and two samples having four genes in common with HNSCC each. Several samples with mutations in p53 and mutations in genes implicated in HNSCC suggests that the domestic cat could be a viable model for HNSCC.

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Section: Soft Tissue Sarcomamentioning

confidence: 99%

Section: Soft Tissue Sarcomamentioning

confidence: 99%

Characterization of the genetic landscape of feline oral squamous cell carcinoma

Rodney¹

View full text Add to dashboard Cite

show abstract

Renal Neoplasia

Cited by 1 publication

References 31 publications

Characterization of the genetic landscape of feline oral squamous cell carcinoma

Characterization of the genetic landscape of feline oral squamous cell carcinoma

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