Systemic Amyloidosis Associated with a Benign Mesenteric Lymphoid Mass

Pilon, Vernon A.; Gomez, Luis G.; Butler, James J.

doi:10.1093/ajcp/78.1.112

Cited by 40 publications

(15 citation statements)

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“…Various lesions have been described, ranging from all kinds of glomerulonephritis (minimal change [5], membranous [6, 7], mesangial [4], membranoproliferative [8, 9], crescentic [10, 11], fibrillar [12]) to amyloidosis [2, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23]. Renal amyloidosis has hitherto been reported in only 11 CD patients in whom a renal biopsy was done.…”

Section: Introductionmentioning

confidence: 99%

Remission of Nephrotic Syndrome due to AA Amyloidosis and Initiation of Glomerular Repair after Surgical Resection of Localized Castleman’s Disease

Mandreoli

Casanova

Vianelli

et al. 2002

Nephron

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To shed further light on the eventual destiny of amyloid kidney deposits after interruption of amylogenic stimulus, we report a case of a 47-year-old woman with nephrotic syndrome due to renal amyloidosis, complicating abdominal Castleman’s disease. After 5 courses of therapy with melphalan and prednisolone which failed to improve the nephrotic syndrome or her general clinical condition, and 1 year after the diagnosis of renal amyloidosis, surgical excision of the abdominal mass was performed. Whereas her clinical symptoms and other laboratory findings rapidly improved, the proteinuria took 18 months to disappear. A second renal biopsy, performed 30 months after surgical resection, showed persistence of the amyloid deposits in the same extent. However, electron microscopy revealed subtle reparative phenomena at the epithelial site of the basement membrane. We conclude that proteinuria associated with amyloidosis does not only depend on structural damage and that the new synthesized segment of basement membrane observed by us probably represents a mechanism of repair and the start of a long healing process.

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Section: Introductionmentioning

confidence: 99%

Remission of Nephrotic Syndrome due to AA Amyloidosis and Initiation of Glomerular Repair after Surgical Resection of Localized Castleman’s Disease

Mandreoli

Casanova

Vianelli

et al. 2002

Nephron

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“…Most of these cases had nephrotic syndrome due to renal amyloidosis [11,12]. In previously reported cases of systemic amyloidosis with CD, they were mostly defined as the AA type [5,11,12]. In this case, we could not detect amyloid deposits except for the kidneys in which the amyloid was stained with serum amyloid protein A.…”

Section: Discussionmentioning

confidence: 55%

“…The presence of amyloidosis in association with MCD is a rare but documented finding [5]. Some cases of CD associated with nephropathy have been reported and showed poor response to therapy in nephrotic syndrome and/or end-stage renal disease.…”

Section: Introductionmentioning

confidence: 99%

A Case of Multicentric Castleman’s Disease Associated with Renal Amyloidosis and Pure Red Cell Aplasia

Funabïki¹,

Kaneko²,

Terajima³

et al. 1998

Am J Nephrol

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This is the first reported case of multicentric Castleman’s disease (MCD) associated with renal amyloidosis and pure red cell aplasia (PRCA). Inguinal lymph node biopsy showed follicular hyperplasia with prominent germinal centers and plasma cell proliferation in the interfollicular areas. Renal biopsy specimens revealed intraglomerular amyloid deposits, defined as AA amyloidosis. Since amyloid deposits were not present in the gastric and rectal mucosal tissues, his renal disorder was found to be an unusual secondary amyloidosis associated with MCD. Following treatment by plasma exchange, there was progressive deterioration of anemia due to PRCA detected by bone marrow aspiration. Subsequently he was successfully treated with steroid pulse therapy not only for anemia but also for renal function.

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“…Only few of the nephrotic patients have been biopsied, and various histological lesions have been described (table l). They ranged from minimal change [15,16] to membranous nephropathy [17,18], interstitial nephritis [19] and amyloidosis [20], The finding of membranoproliferative glomerulonephri tis (MPGN) in our nephrotic patient with ALNH (plasma cell type) is a new one, and to our knowledge, such an association has not been reported previously.…”

Section: Introductionmentioning

confidence: 71%

Membranoproliferative Glomerulonephritis Associated with Multicentric Angiofollicular Lymph Node Hyperplasia

Said

Tarawneh²

1992

Am J Nephrol

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A 14-year-old boy presented with fever, anemia, hepatosplenomegaly, generalized lymphadenopathy and nephrotic syndrome. Lymph node biopsy showed angiofollicular lymph node hyperplasia (generalized Castleman’s disease) of the plasma cell type. Kidney biopsy showed membranoproliferative glomerulonephritis type 1. Complete remission was achieved with corticosteroid treatment and repeat kidney biopsy 22 months later showed complete resolution of the renal pathology. The association between membranoproliferative glomerulonephritis and multicentric angiofollicular lymph node hyperplasia, plasma cell type, has not previously been reported.

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Systemic Amyloidosis Associated with a Benign Mesenteric Lymphoid Mass

Cited by 40 publications

References 0 publications

Remission of Nephrotic Syndrome due to AA Amyloidosis and Initiation of Glomerular Repair after Surgical Resection of Localized Castleman’s Disease

Remission of Nephrotic Syndrome due to AA Amyloidosis and Initiation of Glomerular Repair after Surgical Resection of Localized Castleman’s Disease

A Case of Multicentric Castleman’s Disease Associated with Renal Amyloidosis and Pure Red Cell Aplasia

Membranoproliferative Glomerulonephritis Associated with Multicentric Angiofollicular Lymph Node Hyperplasia

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