The aim of the present study was to prepare and evaluate the transdermal patch of drug using different polymers such as hydrophobic, combination of hydrophobic: hydrophilic, and hydrophilic. Losartan potassium (hydrophilic) is the antihypertensive drug used for lowering increased blood pressure. Transdermal patches of losartan potassium were prepared using different ratios of polymers by the solvent casting technique. The prepared patches were evaluated for their flexibility, thickness, smoothness, moisture content, hardness, and tensile strength. The in vitro permeation study was carried out using a diffusion cell. The blood lowering response of all formulations was studied using hypertension-induced rats. The formulation containing hydrophobic polymers showed a satisfactory drug release pattern compared to the combination of hydrophobic: hydrophilic polymers and the hydrophilic polymers. Hence, the present study reveals that formulation of hydrophilic drug (losartan potassium) withhydrophobic polymers exhibit good release properties as compared to that of hydrophilic polymers and combination of both hydrophobic and hydrophilic polymers.
The objective of the present work was to develop a matrix-type transdermal drug delivery system of lornoxicam with the addition of ethyl cellulose:polyvinylpyrrolidone and Eudragit RL 100:Eudragit RS 100 in different ratios with propylene glycol as plasticizer (5%) and tween 80 as permeation enhancer using the solvent evaporation technique. Lornoxicam is a non-steroidal anti-inflammatory drug that is used for the treatment of pain, inflammation, and arthritis. The prepared patches were evaluated for mechanical characterization and in vitro permeation studies. The formulations showing best results (A3 and B3) were selected further for in vivo and pharmacokinetic studies on animals. From the results, it was found that formulations A3 and B3 exhibited greatest cumulative amount of drug release, controlled inflammation, and showed analgesic effect from the first hour. Hence, lornoxicam can be formulated into transdermal patches, and formulations A3 and B3 were found to be the best choice to manufacture a lornoxicam transdermal drug delivery system.
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