Development of Matrix-Type Transdermal Delivery of Lornoxicam: In Vitro Evaluation and Pharmacodynamic and Pharmacokinetic Studies in Albino Rats

Baviskar, Dheeraj T.; Parik, Venkatesh B.; Jain, Dinesh J.

doi:10.5731/pdajpst.2013.00898

Cited by 12 publications

(7 citation statements)

References 22 publications

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“…Similar results were demonstrated by Baviskar et al where the matrix-type lornoxicam patches exhibited potent analgesic effect against thermal pain stimuli. [35]. Statistically, a significant difference was observed (P < 0.01) in the reaction time between the test and control group.…”

Section: In Vivo Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 76%

“…Animals were divided into three groups (n = 6 for each group). Group I served as control, group II served as standard and received 4mg/kg LRX orally [35] and group III was treated with the optimized patch (4 cm 2 ). The test patch was applied topically on the posterior paw of each rat of the treated group and the response time was recorded after 0, 30, 60, 120 and 180 min after application.…”

Section: In Vivo Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

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Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers

et al. 2020

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The aim of the current study was to develop membrane-based transdermal patches of lornoxicam gel using oleic acid (OA)and propylene glycol (PG) as penetration enhancers to improve drug delivery across the skin and to evaluate in vivo analgesic and anti-inflammatory activity. For this purpose, nine formulations were developed in accordance with 3 2 factorial design using Design Expert ® 11. The concentration of propylene glycol (X 1) and oleic acid (X 2) were selected as independent variable whereas Q 10 (Y 1), flux (Y 2) and lag time (Y 3) were considered as the response variables. The impact of drug loading, surface area, gel concentration, membrane variation and agitation speed on drug release and permeation was also studied. The skin sensitivity reaction, analgesic activity and anti-inflammatory action of the optimized patch were also determined in Albino Wistar rats. Stability studies were performed for three months at three different temperature conditions. The result suggests that a membrane-based system with controlled zero-order drug release of 95.8 ± 1.121% for 10 h exhibiting flux of 126.51±1.19 μg/cm 2 /h and lag time of 0.908 ±0.57h was optimized with the desired analgesic and anti-inflammatory effect can be obtained by using propylene glycol and oleic acid co-solvents as a penetration enhancer. The patch was also found stable at 4˚C for a period of 6.44 months. Formulation F9 comprising of 10% PG and 3% OA was selected as an optimized formulation. The study demonstrates that the fabricated transdermal system of lornoxicam can deliver the drug through the skin in a controlled manner with desired analgesic and anti-inflammatory activity and can be considered as a suitable alternative of the oral route.

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Section: In Vivo Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 76%

Section: In Vivo Analgesic and Anti-inflammatory Activitiesmentioning

confidence: 99%

Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers

et al. 2020

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“…For the determination of the drug content of UHAE and UEO patches, samples were analyzed spectrophotometrically at 273 and 278 nm wavelength, respectively, after suitable dilution with phosphate buffer pH 7.4. Each experiment was performed in triplicate [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…Each experiment was conducted in triplicate. Cumulative amounts of drug permeated were calculated in micrograms per square centimetre (μg/cm 2 ) and plotted against time [ 28 ].…”

Section: Methodsmentioning

confidence: 99%

In vitro and Ex vivo study targeting the development of a Lavandula stoechas L. (Ustukhuddūs) loaded Unani Transdermal patch: Implication of Unani Medicine in the treatment of Nisyan (Dementia)

Fathima A,

Khan,

Irfhan N

et al. 2024

Heliyon

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“…1: Kp= Jss/C. 26,27 For this section, the protocols of animal handling procedures were performed in accordance with the CPCSEA guidelines.…”

Section: In Vitro Characterization Of Reservoir Gelmentioning

confidence: 99%

Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems

Sreeharsha¹,

Hiremath²,

Rawre³

et al. 2019

IJPER

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Background: Successful treatment of cancer is yet remained as a challenging concern in public health. Transdermal delivery of hormonal therapy offers several advantages over the oral route associated with potential side effects. Methods: The present investigation preparation and screening of rate controlling membranes using Eudragit release liners of RS 100, hydroxyl propyl methyl cellulose K4M (HPMC K4M) and ethyl cellulose by plate casting method and their physicochemical characterization. The prepared release liners were subjected for preformualtion studies (thickness, weight variation, moisture uptake, folding endurance and moisture loss). Tamoxifen citrate is an ideal molecule for the transdermal reservoir for the preparation of gel dosage form due its dosage regimen. Results: The main investigation, topical gel TC was prepared using HPMC K4M and Carbopol 934 as gelling agents in different proportions with Dimethyl Sulfoxide (DMSO) as a penetration enhancer. TC gels were subjected for the physicochemical parameters such as pH, viscosity, spreadability. Conclusion: The TC gel diffusion was conducted by using rate controlling membranes (release liner). The TC gel skin permeation was investigated by using excised rat skin as a barrier.

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Development of Matrix-Type Transdermal Delivery of Lornoxicam: In Vitro Evaluation and Pharmacodynamic and Pharmacokinetic Studies in Albino Rats

Cited by 12 publications

References 22 publications

Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers

Lornoxicam controlled release transdermal gel patch: Design, characterization and optimization using co-solvents as penetration enhancers

In vitro and Ex vivo study targeting the development of a Lavandula stoechas L. (Ustukhuddūs) loaded Unani Transdermal patch: Implication of Unani Medicine in the treatment of Nisyan (Dementia)

Formulation and Evaluation of Tamoxifen Citrate Loaded Transdermal Reservoir Gel Drug Delivery Systems

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