The aim of the present study was to prepare and evaluate the transdermal patch of drug using different polymers such as hydrophobic, combination of hydrophobic: hydrophilic, and hydrophilic. Losartan potassium (hydrophilic) is the antihypertensive drug used for lowering increased blood pressure. Transdermal patches of losartan potassium were prepared using different ratios of polymers by the solvent casting technique. The prepared patches were evaluated for their flexibility, thickness, smoothness, moisture content, hardness, and tensile strength. The in vitro permeation study was carried out using a diffusion cell. The blood lowering response of all formulations was studied using hypertension-induced rats. The formulation containing hydrophobic polymers showed a satisfactory drug release pattern compared to the combination of hydrophobic: hydrophilic polymers and the hydrophilic polymers. Hence, the present study reveals that formulation of hydrophilic drug (losartan potassium) withhydrophobic polymers exhibit good release properties as compared to that of hydrophilic polymers and combination of both hydrophobic and hydrophilic polymers.
Nasal administration offers an interesting promising alternative technique to the parenteral route for achieving systemic drug effects. Now a day many drugs have better systemic bioavailability through nasal route as compared to oral administration. Microemulsion is dispersed, macroscopically homogenous thermodynamically stable, optically transparent, single phase system, formed by spontaneous solubilisation of two immiscible liquid, in the presence of surfactants. Microemulsion offers number of advantages than drug formulation for nasal drug delivery. Ziprasidone is lipophilic, benz-isothiazoyl-piperazine derivative, used in the treatment of schizophrenia, mania and mixed states associated with bipolar disorder. The microemulsion was prepared by precipitation method. The characterization of microemulsion formulation includes determination of viscosity, pH, drug content, refractive, conductivity measurement, zeta potential analysis and particle size analysis. In-vitro drug permeation studies were done by using Keshary Diffusion cell. All ME formulations were shown fast drug permeation 99.50 % for ME 2 within 1 h and 99.40 % for ME 6 within 100 minutes since the ME 2 which is optimized on the basis of in-vitro study. Nasal mucoadhesive drug delivery system is designed with an aim to target the drug and to maintain the dosage form at its absorption site for a rapid onset of time. This will result in the enhancement of the absorption of the drug, which will in turn reduce the presystemic metabolism; increase the bioavailability of the drug, initiate rapid onset of action and thus will decrease the dosing frequency and dose related side effects of the drug. For this purpose in microemulsion system is preferred over conventional solution system
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